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Patricia A. D'Amore, PhD, MBA, FARVO

Charles L. Schepens Professor of Ophthalmology, Department of Ophthalmology, Harvard Medical School

Professor, Department of Pathology, Harvard Medical School

Contact Info

Patricia D'Amore
Schepens Eye Research Institute
20 Staniford Street

Boston, MA, 02114
Mailstop: Schepens Eye Research
Phone: 617-912-2559
Fax: 617-912-0128
patricia_damore@meei.harvard.edu

Assistant

Christine Bagley
Executive Assistant
Ophthalmology
Schepens Eye Research Institute
20 Staniford Street
3rd Flr.
Boston, MA, 02114
Phone: 617-912-2560
Fax: 617-912-0128
christine.bagley@meei.harvard.edu
Erin Porter
Administrative Assistant
Schepens Eye Research Institute
20 Staniford Street
Boston, MA, 02114
Phone: 617-912-2561
erin_porter@meei.harvard.edu

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis
Breast Cancer

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

The D’Amore laboratory has a long-standing interest in the regulation of vascular development and pathology. One major area has involved investigating the role and regulation of VEGF in adult vascular and non-vascular cells. More recently, her laboratory has been examining the regulation of inflammation at the level of the vasculature. The laboratory is currently focused in three general areas. Two of those relate to understanding the molecular basis of blood vessel stabilization. One project is examining the role of Notch signaling in the stabilization of the microvasculature. A related project is aimed at elucidating other mechanisms that may mediate pericyte stabilization of the capillaries. Studies in both research areas are utilizing genetic model as well as tissues culture systems. A second project is examining a novel endothelial-specific molecule endomucin in the regulation of leukocyte-endothelial interactions, a central and early step in the inflammatory process.

Publications

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