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Alan D. D'Andrea, MD

Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology, Department of Radiation Oncology, Harvard Medical School

Professor, Department of Pediatrics, Harvard Medical School

Scientific Director, Molecular Diagnostics Laboratory, Dana-Farber Cancer Institute

Contact Info

Alan D'Andrea
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Mayer 640
Phone: 617-632-2112
Fax: 617-632-5757
alan_dandrea@dfci.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Lung Cancer
Breast Cancer

Research Abstract

Fanconi Anema (FA) is an autosomal recessive disease characterized by progressive bone marrow failure and cancer susceptibility. Cells from patients with FA are hypersensitive to DNA-damaging agents, and the molecular defect is presumably one of DNA repair. FA has at least eight complementation groups (A-H), and three FA genes, corresponding to complementation groups A, C, and G have been cloned. We have recently demonstrated that the FANCA, FANCC, and FANCG proteins bind and form a nuclear complex, although the function of this complex remains unknown. More recently, we have demonstrated that the FANCA protein is phosphorylated and that its phosphorylation correlates with FANCC and FANCG binding and nuclear accumulation. Interestingly, other (non-A, C, G) FA cells are defective in FANCA phosphorylation, FA protein binding, and nuclear accumulation of the complex, suggesting that other FA gene products also regulate this pathway. Disruption of the pathway leads to chromosome instability and leukemia. On-going projects include the identification and cloining of other proteins in the FA complex and the biochemical assessment of the function of the nuclear FA complex.

Publications

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