DF/HCC Program Affiliation

Lymphoma and Myeloma, Leader

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

My laboratory and clinical interests are primarily in the area of aggressive B-cell non-Hodgkin's lymphomas. In the laboratory, we are attempting to identify cellular and molecular features which contribute to the unique natural histories of clinically relevant subsets of patients with aggressive B-cell lymphomas. These laboratory-based initiatives are closely integrated with longstanding clinical efforts to identify and treat subsets of patients whose aggressive B-cell lymphomas have very different natural histories. Another major area of emphasis in the laboratory is the interaction between tumor cells and surrounding stroma and the development of a conducive tumor microenvironment. We have developed in vitro models to analyze the events associated with the interaction between epithelial carcinoma cells and stromal elements and have begun to develop similar informative in vitro models for the interaction between aggressive B-cell lymphomas and relevant stromal components.

Publications

• Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, De Leval L, Kurtin P, Dal Cin P, Ladd C, Feuerhake F, Aguiar RC, Li S, Salles G, Berger F, Jing W, Pinkus GS, Habermann T, Dalla-Favera R, Harris NL, Aster JC, Golub TR, Shipp MA.The molecular signatu
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• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA.The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.J Biol Chem 2003 Jun 13;278(24):21930-7.
  12670957
• Aguiar RC, Yakushijin Y, Kharbanda S, Tiwari S, Freeman GJ, Shipp MA.PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.Blood 1999 Oct 1;94(7):2403-13.
  10498613
• Yakushijin Y, Steckel J, Kharbanda S, Hasserjian R, Neuberg D, Jiang W, Anderson I, Shipp MA.A directly spliced exon 10-containing CD44 variant promotes the metastasis and homotypic aggregation of aggressive non-Hodgkin's lymphoma.Blood 1998 Jun 1;91(11):
  9596677
• Mari BP, Anderson IC, Mari SE, Ning Y, Lutz Y, Kobzik L, Shipp MA.Stromelysin-3 is induced in tumor/stroma cocultures and inactivated via a tumor-specific and basic fibroblast growth factor-dependent mechanism.J Biol Chem 1998 Jan 2;273(1):618-26.
  9417124