Dimitrios Trichopoulos, MD, PhD
Vincent L. Gregory Professor of Cancer Prevention, Department of Epidemiology, Harvard School Of Public Health
DF/HCC Program AffiliationProstate CancerCancer Epidemiology
Dr. Trichopoulos' main research interest is the evaluation of the hypothesis that hormone-dependent cancers have their origin in the intrauterine life and depend on the levels of maternal pregnancy hormones. This hypothesis is compatible with experimental evidence and can explain why it takes more than two generations for the incidence of breast and prostate cancer in Asian immigrants to the U.S. to reach the four times higher incidence prevailing in the host population. The main postulate is that higher levels of pregnancy hormones favor the generation of a higher number of susceptible stem cells with compromised genomic stability. Research in collaboration with Drs. Adami, Ekbom and Hall of Stockholm, Dr. Hsieh in Boston and Dr. Lagiou in Athens has provided supportive evidence for the hypothesis. Dr. Trichopoulos is also studying the nutritional epidemiology of several chronic diseases in the context of the European Prospective Investigation into Cancer and nutrition.
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