DF/HCC Program Affiliation

Prostate Cancer
Cancer Epidemiology

Research Abstract

Dr. Trichopoulos' main research interest is the evaluation of the hypothesis that hormone-dependent cancers have their origin in the intrauterine life and depend on the levels of maternal pregnancy hormones. This hypothesis is compatible with experimental evidence and can explain why it takes more than two generations for the incidence of breast and prostate cancer in Asian immigrants to the U.S. to reach the four times higher incidence prevailing in the host population. The main postulate is that higher levels of pregnancy hormones favor the generation of a higher number of susceptible stem cells with compromised genomic stability. Research in collaboration with Drs. Adami, Ekbom and Hall of Stockholm, Dr. Hsieh in Boston and Dr. Lagiou in Athens has provided supportive evidence for the hypothesis. Dr. Trichopoulos is also studying the nutritional epidemiology of several chronic diseases in the context of the European Prospective Investigation into Cancer and nutrition.

Publications

• Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, Trichopoulos D.Adiponectin and breast cancer risk.J Clin Endocrinol Metab 2004 Mar;89(3):1102-7.
  15001594
• Skalkidou A, Petridou E, Papathoma E, Salvanos H, Trichopoulos D.Growth velocity during the first postnatal week of life is linked to a spurt of IGF-I effect.Paediatr Perinat Epidemiol 2003 Jul;17(3):281-6.
  12839540
• Trichopoulou A, Costacou T, Bamia C, Trichopoulos D.Adherence to a Mediterranean diet and survival in a Greek population.N Engl J Med 2003 Jun 26;348(26):2599-608.
  12826634
• Trichopoulos D.Intrauterine environment, mammary gland mass and breast cancer risk.Breast Cancer Res 2003;5(1):42-4.
  12559045