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Jean J. Zhao, PhD

Associate Professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Associate Professor, Cancer Biology, Dana-Farber Cancer Institute

Contact Info

Jean Zhao
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Smith 1058B
Phone: 617-632-2932
Fax: 617-632-3709
jean_zhao@dfci.harvard.edu

Assistant

Erin Barber
Administrative Assistant
Cancer Biology
Dana-Farber Cancer Institute
44 Binney Street
Boston, MA, 02115
Phone: 617-632-5744
Fax: 617-582-7737
Erin_Barber@DFCI.HARVARD.EDU

DF/HCC Program Affiliation

Prostate Cancer
Breast Cancer

Research Abstract

Kinase signaling in cancer

We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to study oncogenic alterations in kinases that are involved in primary tumor formation and metastasis. In addition to our unique genetically engineered mouse models, we have developed a number of additional experimental systems, including, synthetic human tumors, and kinome-wide libraries of activated kinases to elucidate the mechanisms by which kinases function in cancer. We hope our studies will allow us to harness the potential of these molecules as specific targets for cancer therapies.

Publications

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