DF/HCC Program Affiliation

Cutaneous Oncology and Melanoma
Cancer Genetics

Research Abstract

Our laboratory is interested in the genetic determinants of cutaneous melanoma. We have developed and maintain a registry of familial melanoma patients in order to better understand the genetic loci and mechanisms that contribute to inherited melanoma predisposition. We also have an interest in molecules that participate in the repair of DNA in response to ultraviolet damage.

Publications

• Tsai KY, Tsao H.Primer on the human genome.J Am Acad Dermatol 2007 May;56(5):719-35.
  17437886
• Lang J, Hayward N, Goldgar D, Tsao H, Hogg D, Palmer J, Stark M, Tobias ES, MacKie R.The M53I mutation in CDKN2A is a founder mutation that predominates in melanoma patients with Scottish ancestry.Genes Chromosomes Cancer 2007 Mar;46(3):277-87.
  17171691
• Goldstein AM, Chan M, Harland M, Gillanders EM, Hayward NK, Avril MF, Azizi E, Bianchi-Scarra G, Bishop DT, Bressac-de Paillerets B, Bruno W, Calista D, Cannon Albright LA, Demenais F, Elder DE, Ghiorzo P, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky
  17047042
• Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, Azizi E, Bergman W, Bianchi-Scarra G, Bruno W, Calista D, Albright LA, Chaudru V, Chompret A, Cuellar F, Elder DE, Ghiorzo P, Gillanders EM, Gruis NA, Hansson J, Hogg D, Holland EA, Kanet
  16905682
• Yang G, Zhang G, Pittelkow MR, Ramoni M, Tsao H.Expression Profiling of UVB Response in Melanocytes Identifies a Set of p53-Target Genes.J Invest Dermatol 2006 Aug 3.
  16888633
• Haluska FG, Tsao H, Wu H, Haluska FS, Lazar A, Goel V.Genetic alterations in signaling pathways in melanoma.Clin Cancer Res 2006 Apr 1;12(7 Pt 2):2301s-2307s.
  16609049
• Niendorf KB, Tsao H.Cutaneous melanoma: family screening and genetic testing.Dermatol Ther 2006 Jan-Feb;19(1):1-8.
  16405564
• Stratigos AJ, Yang G, Dimisianos R, Nicolaou V, Stefanaki I, Katsambas AD, Tsao H.Germline CDKN2A mutations among Greek patients with early-onset and multiple primary cutaneous melanoma.J Invest Dermatol 2006 Feb;126(2):399-401.
  16374456
• Tsao H.The SNPs of RAF.J Invest Dermatol 2005 Dec;125(6):xiv-xv.
  16354174
• Yang G, Rajadurai A, Tsao H.Recurrent patterns of dual RB and p53 pathway inactivation in melanoma.J Invest Dermatol 2005 Dec;125(6):1242-51.
  16354195
• Niendorf KB, Goggins W, Yang G, Tsai KY, Shennan M, Bell DW, Sober AJ, Hogg D, Tsao H.MELPREDICT: a logistic regression model to estimate CDKN2A carrier probability.J Med Genet 2006 Jun;43(6):501-6.
  16169933
• Goggins W, Daniels GH, Tsao H.Elevation of thyroid cancer risk among cutaneous melanoma survivors.Int J Cancer 2006 Jan 1;118(1):185-8.
  16049985
• Tsao H, Goel V, Wu H, Yang G, Haluska FG.Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.J Invest Dermatol 2004 Feb;122(2):337-41.
  15009714
• Tsao H, Feldman M, Fullerton JE, Sober AJ, Rosenthal D, Goggins W.Early detection of asymptomatic pulmonary melanoma metastases by routine chest radiographs is not associated with improved survival.Arch Dermatol 2004 Jan;140(1):67-70.
  14732662
• Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricalà C, O'Toole KM.A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.Mol Cell Biol 2002 Jul
  12077343
• Tsao H, Zhang X, Kwitkiwski K, Finkelstein DM, Sober AJ, Haluska FG.Low prevalence of germline CDKN2A and CDK4 mutations in patients with early-onset melanoma.Arch Dermatol 2000 Sep;136(9):1118-22.
  10987867
• Tsao H, Zhang X, Fowlkes K, Haluska FG.Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.Cancer Res 2000 Apr 1;60(7):1800-4.
  10766161