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David N. Louis, MD

Benjamin Castleman Professor of Pathology, Department of Pathology, Harvard Medical School

Chief, Pathology, Massachusetts General Hospital

Contact Info

David Louis
Massachusetts General Hospital
Warren 225
Boston, MA, 02114
Phone: 617-726-2966
Fax: 617-726-7533
Email not available


Karen Graham
Executive Staff Assistant
Pathology Service
Massachusetts General Hospital
55 Fruit St.
Boston, MA, 02114
Phone: 617-726-2966
Fax: 617-726-7533

DF/HCC Program Affiliation

Cancer Genetics

Research Abstract

Dr. Louis' laboratory has studied the molecular genetic basis of human brain tumors, both common sporadic brain tumors as well as rarer, inherited brain tumor syndromes. Most of the work has focused on malignant gliomas. The laboratory was the first to demonstrate that molecular genetic analysis could be used to divide glioblastomas into clinicopathologically distinct genetic subsets. The laboratory has also shown that specific genetic alterations are powerful predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. Recent work focused on the effects of chemotherapy on malignant glioma genotype at the time of recurrence and, in collaboration, on glioma epigenetics.


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