DF/HCC Program Affiliation

Neuro-Oncology
Cancer Genetics

DF/HCC Associations

Director, Neuro Oncology

Research Abstract

Dr. Louis' laboratory studies the molecular genetic basis of human brain tumors, both common sporadic brain tumors as well as rarer, inherited brain tumor syndromes. Most of the work has focused on malignant gliomas. The laboratory was the first to demonstrate that molecular genetic analysis could be used to divide glioblastomas into clinicopathologically distinct genetic subsets. The laboratory has also shown that specific genetic alterations are powerful predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. Recent work has focused on the effects of chemotherapy on malignant glioma genotype at the time of recurrence.

Publications

• Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN.Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomid
  17404084
• Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Hal
  17344846
• Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH.Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.Ne
  17296553
• Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.AZD2171, a pan-VEGF receptor ty
  17222792
• Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L.Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.Genes Dev 2007 Jan 1;21(1):98-111.
  17210792
• Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL.Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival.J Neuropathol Exp Neurol 2006 Dec;65(12):1181-8.
  17146292
• Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN.Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.J Neuropathol Exp Neurol 2006 Dec;65(12):1149-56.
  17146289
• Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA.Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct mo
  17114236
• Fulci G, Breymann L, Gianni D, Kurozomi K, Rhee SS, Yu J, Kaur B, Louis DN, Weissleder R, Caligiuri MA, Chiocca EA.Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses.Proc Natl Acad Sci U S A 2006 Aug 22;103(34):12873-8.
  16908838
• Mueller W, Nutt CL, Ehrich M, Riemenschneider MJ, von Deimling A, van den Boom D, Louis DN.Downregulation of RUNX3 and TES by hypermethylation in glioblastoma.Oncogene 2007 Jan 25;26(4):583-93.
  16909125
• Iliopoulos O, Chan-Smutko G, Gonzalez RG, Louis DN, Stone JR.Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the right hand and hypertension.N Engl J Med 2006 Jul 27;355(4):394-402.
  16870919
• Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN.AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.Cancer Res 2006 Jun 1;66(11):5618-23.
  16740698
• Mohapatra G, Betensky RA, Miller ER, Carey B, Gaumont LD, Engler DA, Louis DN.Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ
  16645215
• Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, Teague J, Greenman C, Edkins S, Bignell G, Davies H, O'Meara S, Parker A, Avis T, Barthorpe S, Brackenbury L, Buck G, Butler A, Clements J, Cole J, Dicks E, Forbes S, Gorton M, Gray K, Halliday K, Harri
  16618716
• Engler DA, Mohapatra G, Louis DN, Betensky RA.A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations.Biostatistics 2006 Jul;7(3):399-421.
  16401686
• Aghi M, Gaviani P, Henson JW, Batchelor TT, Louis DN, Barker FG.Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastoma.Clin Cancer Res 2005 Dec 15;11(24 Pt 1):8600-5.
  16361543
• Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN.Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma.J Neuropathol Exp Neurol 2005 Nov;64(11):948-955.
  16254489
• Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN.In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation.Am J Pathol 2005 N
  16251422
• Henson JW, Hobbs W, Chakravarti A, Louis DN.Alterations in p53, p21, and MIB-1 labeling index in primary human astrocytomas following radiation therapy.J Neurooncol 2005 Sep;74(2):151-4.
  16193385
• McDonald JM, See SJ, Tremont IW, Colman H, Gilbert MR, Groves M, Burger PC, Louis DN, Giannini C, Fuller G, Passe S, Blair H, Jenkins RB, Yang H, Ledoux A, Aaron J, Tipnis U, Zhang W, Hess K, Aldape K.The prognostic impact of histology and 1p/19q status i
  16088966
• Ma D, Nutt CL, Shanehsaz P, Peng X, Louis DN, Kaetzel DM.Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and i
  15994924
• Shih HA, Betensky RA, Dorfman MV, Louis DN, Loeffler JS, Batchelor TT.Genetic analyses for predictors of radiation response in glioblastoma.Int J Radiat Oncol Biol Phys 2005 Nov 1;63(3):704-10.
  15978739
• Dahiya S, Sarkar C, Hedley-Whyte ET, Sharma MC, Zervas NT, Sridhar E, Louis DN.Spindle cell oncocytoma of the adenohypophysis: report of two cases.Acta Neuropathol 2005 Jul;110(1):97-9.
  15973544
• Mueller W, Mizoguchi M, Silen E, D'Amore K, Nutt CL, Louis DN.Mutations of the PIK3CA gene are rare in human glioblastoma.Acta Neuropathol 2005 Jun;109(6):654-5.
  15924252
• Betensky RA, Nutt CL, Batchelor TT, Louis DN.Statistical considerations for immunohistochemistry panel development after gene expression profiling of human cancers.J Mol Diagn 2005 May;7(2):276-82.
  15858152
• Nutt CL, Betensky RA, Brower MA, Batchelor TT, Louis DN, Stemmer-Rachamimov AO.YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas.Clin Cancer Res 2005 Mar 15;11(6):2258-64.
  15788675
• Kreiger PA, Okada Y, Simon S, Rorke LB, Louis DN, Golden JA.Losses of chromosomes 1p and 19q are rare in pediatric oligodendrogliomas.Acta Neuropathol 2005 Apr;109(4):387-92.
  15739101
• Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Re
  15150133
• Batchelor TT, Betensky RA, Esposito JM, Pham LD, Dorfman MV, Piscatelli N, Jhung S, Rhee D, Louis DN.Age-dependent prognostic effects of genetic alterations in glioblastoma.Clin Cancer Res 2004 Jan 1;10(1 Pt 1):228-33.
  14734474
• Nutt CL, Mani DR, Betensky RA, Tamayo P, Cairncross JG, Ladd C, Pohl U, Hartmann C, McLaughlin ME, Batchelor TT, Black PM, von Deimling A, Pomeroy SL, Golub TR, Louis DN.Gene expression-based classification of malignant gliomas correlates better with surv
  12670911
• Reifenberger G, Louis DN.Oligodendroglioma: toward molecular definitions in diagnostic neuro-oncology.J Neuropathol Exp Neurol 2003 Feb;62(2):111-26.
  12578221
• Cairncross JG, Ueki K, Zlatescu MC, Lisle DK, Finkelstein DM, Hammond RR, Silver JS, Stark PC, Macdonald DR, Ino Y, Ramsay DA, Louis DN.Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.J
  9776413
• Rosenberg JE, Lisle DK, Burwick JA, Ueki K, von Deimling A, Mohrenweiser HW, Louis DN.Refined deletion mapping of the chromosome 19q glioma tumor suppressor gene to the D19S412-STD interval.Oncogene 1996 Dec 5;13(11):2483-5.
  8957092
• Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN.CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.Cancer Res 1996 Jan 1;56(1):150-3.
  8548755