DF/HCC Program Affiliation

Prostate Cancer
Kidney Cancer

DF/HCC Associations

Member, Center Scientific Council
Pathologist, Specialized HistoPathology
Director, Tissue MicroArray & Imaging

Research Abstract

My research interest is focused on identifying molecular mechanisms potentially critical for the pathogenesis and/or progression of prostate cancer and validating them in clinical specimens. I'm currently working on the possible role of the Her-2-neu oncogene in the progression towards androgen independence.

In addition, in the attempt of isolating prostate stem cells, I am investigating the role of the recently cloned p53 homologue, p63, in prostate development.

Publications

• Sabir A, Schor-Bardach R, Wilcox CJ, Rahmanuddin S, Atkins MB, Kruskal JB, Signoretti S, Regan M, Raptopoulos VD, Goldberg SM.Multislice CT Perfusion Imaging Enables Early Detection of Therapeutic Response to Antiangiogenic Therapy.Radiology 2007 Mar 01;I
• Signoretti S, Pires MM, Lindauer M, Horner JW, Grisanzio C, Dhar S, Majumder P, McKeon F, Kantoff PW, Sellers WR, Loda M.p63 regulates commitment to the prostate cell lineage.Proc Natl Acad Sci U S A 2005 Aug 9;102(32):11355-60.
  16051706
• Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC.Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide
  16006513
• Atkins M, Regan M, McDermott D, Mier J, Stanbridge E, Youmans A, Febbo P, Upton M, Lechpammer M, Signoretti S.Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer.Clin Cancer Res 2005 May 15;11(10):3714-21.
  15897568
• Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC.Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.Cancer Res 2004 Dec 15;64(24):8867-7
  15604246
• Signoretti S, Di Marcotullio L, Richardson A, Ramaswamy S, Isaac B, Rue M, Monti F, Loda M, Pagano M.Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.J Clin Invest 2002 Sep;110(5):633-41.
  12208864