Research Abstract

My laboratory focuses on transcriptional regulation of immune response genes by histone deacetylases. We cloned histone deacetylase 3 (HDAC3) in human and mouse and are actively working in elucidating its function. Our goal is to establish the molecular mechanisms that explain the association of histone deacetylases with autoimmunity and cancer. Of particular interest is the potential role of HDACs in acute myeloid leukemia and acute promyelocytic leukemia. Finally, my laboratory explores the profiles of gene expression in hematologic cancer, searching for genes that mediate central nervous system invasion by cancer cells.

Publications

• Dangond F, Foerznler D, Weremowicz S, Morton CC, Beier DR, Gullans SR.Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5.Mol Cell Biol Res
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• Dangond F, Gullans SR.Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate.Biochem Biophys Res Commun 1998 Jun 29;247(3):833-7.
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• Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR.Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells.Biochem Biophys Res Commun 1998 Jan 26;242(3):648-52.
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