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Leslie E. Silberstein, MD

Professor, Department of Pathology, Harvard Medical School

Director, Joint Program in Transfusion Medicine, Boston Children's Hospital

Contact Info

Leslie Silberstein
Brigham And Women's Hospital; Boston children's hospital
807 Enders Building

Boston, MA, 02115
Mailstop: Karp Building, 10217
Phone: 617-919-2588
Fax: 617-730-0765


Pamela Quattrocchi
Laboratory Medicine
Boston Children's Hospital
300 Longwood Avenue
807 enders building
boston, MA, 02115
Phone: 617-919-2588

DF/HCC Program Affiliation

Cancer Immunology

DF/HCC Associations

Chief, Joint Program in Transfusion Medicine, Cell Manipulation

Research Abstract

In the bone marrow, hematopoietic stem and progenitor (HSPC) reside in close contact with stromal cells in distinct anatomical microenvironments, where they receive signals for retention as well as growth and maturation. A long-term objective of Dr. Silberstein’s research laboratory is to better define the role of specified bone marrow microenvironments in regulating HSPC development. To this end, the lab has developed novel quantitative imaging tools for 2D and 3D visualization of different bone marrow compartments including the distribution of both hematopoietic and non-hematopoietic cells, e.g. vascular and stromal cells. Complemented by molecular and cellular approaches, my goal is to understand how niche cells influence the dynamic nature of hematopoiesis in health and disease. On-going studies are focused on understanding how inflammatory signals modulate niche cells and concomitantly hematopoiesis. Ultimately, these studies may lead to opportunities for targeted therapeutic regeneration in various bone marrow disorders associated with cancer and acute and/or chronic inflammation.


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