DF/HCC Program Affiliation

Chemoprevention, Leader
Reduction of Cancer Risk and Disparities
Cancer Epidemiology

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

The primary focus of my research has been on the epidemiology of chronic diseases, particularly cancer and cardiovascular diseases, and especially among women. I am Principal Investigator or Co-Investigator of four large-scale randomized clincal trials or observational cohorts: the Women's Health Study, observational follow-up of a primary prevention trial evaluating the balance of benefits and risks of low dose aspirin and vitamin E on cancer and cardiovascular disease among 40,000 female health professionals; the Women's Antioxidant Cardiovascular Study, a secondary prevention trial evaluating the roles of vitamin E, vitamin C, beta-carotene and folic acid/B6/B12 among 8,000 women with a prior history of heart disease; Physician's Health Study II, evaluating vitamin E, vitamin C, and a multivitamin among 15,000 male physicians, and the Brigham and Women's Hospital Vanguard Center of the Women's Health Initiative, evaluating the roles of low fat diet, postmenopausal hormones, and calcium/vitamin D among over 70,000 women nationwide.

Publications

• Koushik A, Hunter DJ, Spiegelman D, Anderson KE, Arslan AA, Beeson WL, van den Brandt PA, Buring JE, Cerhan JR, Colditz GA, Fraser GE, Freudenheim JL, Genkinger JM, Goldbohm RA, Hankinson SE, Koenig KL, Larsson SC, Leitzmann M, McCullough ML, Miller AB, P
  16172226
• McGrath M, Lee IM, Hankinson SE, Kraft P, Hunter DJ, Buring J, De Vivo I.Androgen receptor polymorphisms and endometrial cancer risk.Int J Cancer 2005 Sep 13.
  16161040
• Cook NR, Lee IM, Gaziano JM, Gordon D, Ridker PM, Manson JE, Hennekens CH, Buring JE.Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial.JAMA 2005 Jul 6;294(1):47-55.
  15998890
• Lee IM, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, Hennekens CH, Buring JE.Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial.JAMA 2005 Jul 6;294(1):56-65.
  15998891
• Lin J, Zhang SM, Cook NR, Rexrode KM, Liu S, Manson JE, Lee IM, Buring JE.Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States).Cancer Causes Control 2005 Apr;16(3):225-33.
  15947874
• Sesso HD, Buring JE, Zhang SM, Norkus EP, Gaziano JM.Dietary and plasma lycopene and the risk of breast cancer.Cancer Epidemiol Biomarkers Prev 2005 May;14(5):1074-81.
  15894655
• Lin J, Zhang SM, Cook NR, Manson JE, Lee IM, Buring JE.Intakes of calcium and vitamin D and risk of colorectal cancer in women.Am J Epidemiol 2005 Apr 15;161(8):755-64.
  15800268
• Zhang SM, Buring JE, Lee IM, Cook NR, Ridker PM.C-reactive protein levels are not associated with increased risk for colorectal cancer in women.Ann Intern Med 2005 Mar 15;142(6):425-32.
  15767620
• Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, Manson JE, Hennekens CH, Buring JE.A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women.N Engl J Med 2005 Mar 31;352(13):1293-304.
  15753114
• Lin J, Zhang SM, Cook NR, Lee IM, Buring JE.Dietary fat and fatty acids and risk of colorectal cancer in women.Am J Epidemiol 2004 Nov 15;160(10):1011-22.
  15522858
• Higginbotham S, Zhang ZF, Lee IM, Cook NR, Giovannucci E, Buring JE, Liu S,.Dietary glycemic load and risk of colorectal cancer in the Women's Health Study.J Natl Cancer Inst 2004 Feb 4;96(3):229-33.
  14759990
• Higginbotham S, Zhang ZF, Lee IM, Cook NR, Buring JE, Liu S.Dietary glycemic load and breast cancer risk in the Women's Health Study.Cancer Epidemiol Biomarkers Prev 2004 Jan;13(1):65-70.
  14744735
• Sesso HD, Gaziano JM, VanDenburgh M, Hennekens CH, Glynn RJ, Buring JE.Comparison of baseline characteristics and mortality experience of participants and nonparticipants in a randomized clinical trial: the Physicians' Health Study.Control Clin Trials 200
  12505246
• Porch JV, Lee IM, Cook NR, Rexrode KM, Burin JE.Estrogen-progestin replacement therapy and breast cancer risk: the Women's Health Study (United States).Cancer Causes Control 2002 Nov;13(9):847-54.
  12462550
• Buring JE.Special issues related to randomized trials of primary prevention.Epidemiol Rev 2002;24(1):67-71.
  12119858
• Lee IM, Cook NR, Manson JE, Buring JE.Randomised beta-carotene supplementation and incidence of cancer and cardiovascular disease in women: is the association modified by baseline plasma level?.Br J Cancer 2002 Mar 4;86(5):698-701.
  11875728
• Lee IM, Cook NR, Rexrode KM, Buring JE.Lifetime physical activity and risk of breast cancer.Br J Cancer 2001 Sep 28;85(7):962-5.
  11592766
• Cook NR, Le IM, Manson JE, Buring JE, Hennekens CH.Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians' Health Study (United States).Cancer Causes Control 2000 Aug;11(7):617-26.
  10977106
• Liu S, Lee IM, Linson P, Ajani U, Buring JE, Hennekens CH.A prospective study of physical activity and risk of prostate cancer in US physicians.Int J Epidemiol 2000 Feb;29(1):29-35.
  10750600