Marc W. Kirschner, PhD
John Franklin Enders University Professor of Systems Biology, Department of Systems Biology, Harvard Medical School
Chair, Systems Biology, Harvard Medical School
DF/HCC Program AffiliationCancer Cell Biology
My research concerns the regulation of the cell cycle, the nature of hte cytoskeleton, and mechanisms of early vertebrate development. In particular we are concerned with the role of proteolysis in the exit from mitosis and the checkpoint mechanisms at work there. We are also concerned with the role of proteolysis during the G1 period. We have used Xenopus eggs and extracts to dissect these mechanisms biochemically. In addition we have been interested in understanding how actin assembly is regulated by signal transduction mechanisms. Finally, we are trying to understand the early signaling and patterning events of the frog embryo and how these events lead to the establishment of the vertebrate body plan.
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