DF/HCC Program Affiliation

Breast Cancer

Research Abstract

Our principal research interest is the use of radiation therapy in the multidisciplinary management of breast cancer. In particular, we are involved in the development and optimization of breast-conserving therapy for patients with invasive breast cancer and ductal carcinoma in situ.

This work has involved a series of collaborative studies with radiation oncologists, surgeons, pathologists, radiologists, medical oncologists, and medical geneticists to define the optimal use of a variety of modalities, including radiation therapy. Studies have also included evaluations of radiation therapy after mastectomy to improve survival, and collaborative work with investigators in medical physics to ensure the safest and most effective techniques.

Publications

• Landis DM, Luo W, Song J, Bellon JR, Punglia RS, Wong JS, Killoran JH, Gelman R, Harris JR.Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity.Int J Radiat Oncol Biol Phys 2007 Apr 1;67(5):1299-308.
  17275202
• Golshan M, Miron A, Nixon AJ, Garber JE, Cash EP, Iglehart JD, Harris JR, Wong JS.The prevalence of germline BRCA1 and BRCA2 mutations in young women with breast cancer undergoing breast-conservation therapy.Am J Surg 2006 Jul;192(1):58-62.
  16769276
• Lim M, Bellon JR, Gelman R, Silver B, Recht A, Schnitt SJ, Harris JR.A prospective study of conservative surgery without radiation therapy in select patients with Stage I breast cancer.Int J Radiat Oncol Biol Phys 2006 Jul 15;65(4):1149-54.
  16750330
• Wong JS, Kaelin CM, Troyan SL, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Harris JR, Smith BL.Prospective study of wide excision alone for ductal carcinoma in situ of the breast.J Clin Oncol 2006 Mar 1;24(7):1031-6.
  16461781
• Burstein HJ, Bellon JR, Galper S, Lu HM, Kuter I, Taghian AG, Wong J, Gelman R, Bunnell CA, Parker LM, Garber JE, Winer EP, Harris JR, Powell SN.Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophos
  16243442
• Bellon JR, Harris JR.What extent of radiation therapy is standard?.Breast 2005 Dec;14(6):532-40.
  16236515
• Shafman TD, Levitz S, Nixon AJ, Gibans LA, Nichols KE, Bell DW, Ishioka C, Isselbacher KJ, Gelman R, Garber J, Harris JR, Haber DA.Prevalence of germline truncating mutations in ATM in women with a second breast cancer after radiation therapy for a contra
  10612799
• Hayman JA, Hillner BE, Harris JR, Weeks JC.Cost-effectiveness of routine radiation therapy following conservative surgery for early-stage breast cancer.J Clin Oncol 1998 Mar;16(3):1022-9.
  9508186
• Chen MH, Chuang ML, Bornstein BA, Gelman R, Harris JR, Manning WJ.Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals.Circulation 1997 Nov 18;96(10):3269-72.
  9396414