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Michael Klagsbrun, PhD

Patricia A. Donahoe Professor of Surgery (Pathology), Department of Surgery, Harvard Medical School

Principal Investigator, Surgery, Vascular Biology Program, Boston Children's Hospital

Contact Info

Michael Klagsbrun
Boston Children's Hospital, Vascular Biology Program
300 Longwood Avenue

Boston, MA, 02115
Mailstop: BCH3137
Phone: 617-919-2157
michael.klagsbrun@childrens.harvard.edu

Assistant

Melissa Anderson
Senior Administrative Associate
Vascular Biology Program
Boston Children's Hospital
300 Longwood Avenue
Karp Family Research Laboratories 11.124
Boston, MA, 02115
Mailstop: BCH3138
Phone: 617-919-2322
Fax: 617-730-0268
melissa.anderson@childrens.harvard.edu

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

My laboratory's research is focused primarily on vascular growth factors and their receptors. In particular, we study growth factor/receptor-mediated mechanisms associated with angiogenesis. Knowledge of these mechanisms is used to develop angiogenesis inhibitors. VEGF is a major regulator of angiogenesis. We recently identified neuropilin-1 (NRP1) as a VEGF receptor that is expressed by endothelial cells (EC) and tumor cells. NRP is also a receptor for semaphorins, chemorepulsants that repel axons and collapse growth cones. We have found that semaphorins are inhibitors of EC motility, suggesting a possible molecular connection in the mechanisms that regulate neuronal and capillary migration. Recently, we cloned a soluble form of NRP1 (sNRP1). sNRP1 is a VEGF antagonist, and its expression in tumor cells results in decreased vascularity and increased tumor necrosis. Together, these results suggest that antagonists of NRP1 are potential antagonists of angiogenesis and tumor progression.

Publications

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