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David K. Simon, MD, PhD

Associate Professor, Department of Neurology, Harvard Medical School

Staff Physician, Neurology, Beth Israel Deaconess Medical Center

Staff Neurologist, Neurology, Beth Israel Deaconess Medical Center

Contact Info

David Simon
Beth Israel Deaconess Medical Center
330 Brookline Avenue

Boston, MA, 02215
Mailstop: CLS-638
Phone: 617-735-3251
Fax: 617-735-2826
dsimon1@bidmc.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Genetics

Research Abstract

Oxidative damage to DNA accumulates with age in the brain, particularly in mitochondrial DNA (mtDNA). Oxidatively DNA damage can induce point mutations. mtDNA point mutations accumulate with age in the brain, with mutation levels correlating inversely with mitochondrial function. Somatic mtDNA point mutations also accumulate within certain cancers. We are studying the accumulation of mtDNA point mutations in single neurons in the brain and the potential role of these mutations in aging and age-related neurodegeneration. In addition, we are studying the role of mitophagy and the mTOR pathway in regulating levels of somatic mtDNA mutations. These data have potential relevance to aging, age-related neurodegenerative disorders, and cancer.

Publications

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