DF/HCC Program Affiliation

Cancer Imaging

Research Abstract

Our research focus is on Magnetic Resonance Imaging (MRI) of animal models of cancer. Our facilities include an 8.5T vertical 9 cm bore MRI unit, and a 4.7T horizontal 40 cm bore unit. Animal models from mice to rabbits can be studies within these systems. Pulse sequences include standard T1 and T2 weighted sequences, diffusion imaging, magnetization transfer, perfusion, and contrast enhanced studies. Personnel are available to assist in the planning and MRI scanning.

Publications

• Sun Y, Schmidt NO, Schmidt K, Doshi S, Rubin JB, Mulkern RV, Carroll R, Ziu M, Erkmen K, Poussaint TY, Black P, Albert M, Burstein D, Kieran MW.Perfusion MRI of U87 brain tumors in a mouse model.Magn Reson Med 2004 May;51(5):893-9.
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• Weis S, Shintani S, Weber A, Kirchmair R, Wood M, Cravens A, McSharry H, Iwakura A, Yoon YS, Himes N, Burstein D, Doukas J, Soll R, Losordo D, Cheresh D.Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial
  15067321
• Williams A, Gillis A, McKenzie C, Po B, Sharma L, Micheli L, McKeon B, Burstein D.Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications.Am J Roentgenol 2004 Jan
  14684534
• Nelson AL, Algon SA, Munasinghe J, Graves O, Goumnerova L, Burstein D, Pomeroy SL, Kim JY.Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumors.J Neurooncol 2003 May;62(3):259-67.
  12777077
• Burstein D, Gray M.New MRI techniques for imaging cartilage.J Bone Joint Surg Am 2003;85-A Suppl 2:70-7.
  12721347
• Williams A, Oppenheimer RA, Gray ML, Burstein D.Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation.Arthritis Res Ther 2003;5(2):R97-105.
  12718753
• Henkelman RM, Stanisz GJ, Menezes N, Burstein D.Can MTR be used to assess cartilage in the presence of Gd-DTPA2-?.Magn Reson Med 2002 Dec;48(6):1081-4.
  12465122
• Gillis A, Gray M, Burstein D.Relaxivity and diffusion of gadolinium agents in cartilage.Magn Reson Med 2002 Dec;48(6):1068-71.
  12465119