DF/HCC Program Affiliation

Outcomes Research
Cancer Survivorship
Neuro-Oncology

DF/HCC Associations

CHB/DFCI, Neuro-Oncology, Clinical Trial Chairs

Research Abstract

The pediatric brain tumor program has focused on three areas: clinical care, outcomes/long-term follow-up, and translational/ clinical trials development. My focus has been on the latter area (also see Drs Susan Chi and Chris Turner) and is centered on two major aspects: novel biologic agents (ras, PDGFR, ErbB and EGFR small molecule inhibitors) and anti-angiogenic agents (TNP470, thalidomide, SU5416) for children with brain tumors. Using a lab-based pre-clinical model structure, we have initiated a number of clinical trials in these areas through the Children's Oncology Group (COG) and Pediatric Brain Tumor Consortium (PBTC).

Publications

• Ullrich NJ, Robertson R, Kinnamon DD, Scott RM, Kieran MW, Turner CD, Chi SN, Goumnerova L, Proctor M, Tarbell NJ, Marcus KJ, Pomeroy SL.Moyamoya following cranial irradiation for primary brain tumors in children.Neurology 2007 Mar 20;68(12):932-8.
  17372129
• Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D.PPARalpha Deficiency in Inflammatory Cells Suppresses Tumor Growth.PLoS ONE 2007;2:e260.
  17327920
• Pollack IF, Jakacki RI, Blaney SM, Hancock ML, Kieran MW, Phillips P, Kun LE, Friedman H, Packer R, Banerjee A, Geyer JR, Goldman S, Poussaint TY, Krasin MJ, Wang Y, Hayes M, Murgo A, Weiner S, Boyett JM.Phase I trial of imatinib in children with newly di
  17293590
• Sugimoto H, Mundel TM, Kieran MW, Kalluri R.Identification of fibroblast heterogeneity in the tumor microenvironment.Cancer Biol Ther 2006 Dec;5(12):1640-6.
  17106243
• Turner CD, Chi S, Marcus KJ, MacDonald T, Packer RJ, Poussaint TY, Vajapeyam S, Ullrich N, Goumnerova LC, Scott RM, Briody C, Chordas C, Zimmerman MA, Kieran MW.Phase II study of thalidomide and radiation in children with newly diagnosed brain stem glioma
  17031553
• Sathornsumetee S, Hjelmeland AB, Keir ST, McLendon RE, Batt D, Ramsey T, Yusuff N, Rasheed BK, Kieran MW, Laforme A, Bigner DD, Friedman HS, Rich JN.AAL881, a Novel Small Molecule Inhibitor of RAF and Vascular Endothelial Growth Factor Receptor Activities
  16951188
• Ullrich NJ, Marcus K, Pomeroy SL, Turner CD, Zimmerman M, Lehmann LE, Scott RM, Goumnerova L, Gillan E, Kieran MW, Chi SN.Transverse Myelitis After Therapy For Primitive Neuroectodermal Tumors.Pediatr Neurol 2006 Aug;35(2):122-125.
  16876009
• Cornetta K, Croop J, Dropcho E, Abonour R, Kieran MW, Kreissman S, Reeves L, Erickson LC, Williams DA.A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated mod
  16645619
• Waber DP, Pomeroy SL, Chiverton AM, Kieran MW, Scott RM, Goumnerova LC, Rivkin MJ.Everyday cognitive function after craniopharyngioma in childhood.Pediatr Neurol 2006 Jan;34(1):13-9.
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