DF/HCC Program Affiliation

Gastrointestinal Malignancies

Research Abstract

My laboratory focuses on cellular immune responses against hepatitis C virus; specifically, the relationship of the immune response to liver injury and mechanisms of chronicity. Current projects include the role of HCV proteins in attenuating immune responses; the role of HCV specific CD8 and CD4 responses in determining progression to liver fibrosis; and undertandong compartmentalization of immune responses in the liver.

Publications

• Einav S, Koziel MJ.Immunopathogenesis of hepatitis C virus in the immunosuppressed host.Transpl Infect Dis 2002 Jun;4(2):85-92.
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• Exley MA, He Q, Cheng O, Wang RJ, Cheney CP, Balk SP, Koziel MJ.Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver.J Immunol 2002 Feb 15;168(4):1519-23.
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• Kamal SM, Rasenack JW, Bianchi L, Al Tawil A, El Sayed Khalifa K, Peter T, Mansour H, Ezzat W, Koziel M.Acute hepatitis C without and with schistosomiasis: correlation with hepatitis C-specific CD4(+) T-cell and cytokine response.Gastroenterology 2001 Sep
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