DF/HCC Program Affiliation

Gastrointestinal Malignancies
Cancer Imaging

Research Abstract

My research focus is on small animal (mouse) molecular imaging, across all imaging modalities, including MRI, near infrared optical, CT, and single photon nuclear (99mTc, 111In, 125I, etc) systems. We focus broadly on imaging molecular events important to initiation, maintenance and progression of cancer, using a combination of custom-built imaging systems and molecularly specific smart probes for the in vivo detection of these events.

Publications

• Mahmood U, Tung CH, Tang Y, Weissleder R.Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice.Radiology 2002 Aug;224(2):446-51.
  12147841
• Mahmood U, Weissleder R.Some tools for molecular imaging.Acad Radiol 2002 Jun;9(6):629-31.
  12061735
• Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R.Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes.Bioconjug Chem 2002 May-Jun;13(3):554-60.
  12009946
• Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH.Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model.Radiology 2001 Nov;221(2):523-9.
  11687699
• Weissleder R, Mahmood U.Molecular imaging.Radiology 2001 May;219(2):316-33.
  11323453
• Tung CH, Mahmood U, Bredow S, Weissleder R.In vivo imaging of proteolytic enzyme activity using a novel molecular reporter.Cancer Res 2000 Sep 1;60(17):4953-8.
  10987312
• Mahmood U, Tung CH, Bogdanov A, Weissleder R.Near-infrared optical imaging of protease activity for tumor detection.Radiology 1999 Dec;213(3):866-70.
  10580968
• Weissleder R, Tung CH, Mahmood U, Bogdanov A.In vivo imaging of tumors with protease-activated near-infrared fluorescent probes.Nat Biotechnol 1999 Apr;17(4):375-8.
  10207887