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Harvey Cantor, MD

Baruj Benacerraf Professor of Microbiology and Immunobiology, Department of Microbiology and Immunobiology, Harvard Medical School

Chair, Cancer Immunology and AIDS, Dana-Farber Cancer Institute

Contact Info

Harvey Cantor
Dana-Farber Cancer Institute
Dept of Cancer Immunology & AIDS

Boston, MA, 02215
Mailstop: Smith 722
Phone not available.
harvey_cantor@dfci.harvard.edu

Assistant

Alison Angel
Business Manager
Program Manager, DF/HCC Cancer Immunology Program
Dana-Farber Cancer Institute
Dept of Cancer Immunology & AIDs
450 Brookline Avenue
Boston, MA, 02215
Mailstop: SM 722
Phone: 617-632-3328
Fax: 617-632-4630
alison_angel@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

The Cantor lab studies the development and function of T-cell subsets. Early studies indicated that the thymus gave rise to two major lineages of T cells that recognized the MHC class II and class I molecules and were equipped to mediate distinct immunological functions before overt encounter with antigen. These experiments were based on the idea that the pattern of proteins expressed on the cell-surface could be used to separate and define the developmental and functional components of the immune system. This approach was also used to dissect cell-mediated immunity into its cellular components and to isolate natural killer cells, and more recently, to define an inhibitory interaction between natural killer cells and autoreactive TH cells that has led to phase I clinical trials of an antibody that may target this interaction in RA patients.

Current studies in the Cantor lab have begun to define a lineage of CD8+ regulatory T cells (Treg) that inhibits the development of autoimmune disease and may regulate antitumor immunity. Recent studies have suggested that expression of the Helios transcription factor by Treg ensures a stable inhibitory phenotype and maintenance of self tolerance in the face of inflammatory and infectious challenge.

Publications

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