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Matthew R. Smith, MD, PhD

Professor, Department of Medicine, Harvard Medical School

Assistant in Medicine, Hematology/Oncology, Massachusetts General Hospital

Contact Info

Matthew Smith
Massachusetts General Hospital
100 Blossom Street
Boston, MA, 02114
Mailstop: Cox 640
Phone: 617-724-5257
Fax: 617-724-3166


Mary Anne Fallon
Administrative Assistant
Medical Oncology
Massachusetts General Hospital
32 Fruit Street
Boston, MA, 02114
Mailstop: Yawkey 7E, 7037
Phone: 617-724-5257
Fax: 617-726-4899

DF/HCC Program Affiliation

Prostate Cancer, Co-Leader
Cancer Genetics

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

Skeletal complications are a major cause of prostate cancer morbidity. Gonadal steroid deprivation, the mainstay of treatment for advanced prostate cancer, may contribute to the skeletal morbidity of prostate cancer by accelerating bone loss and increasing the rate of osteoporotic fractures. In addition, changes in the bone microenvironment that accompany gonadal steroid deprivation may promote the growth of skeletal metastases. The goal of my research is to understand and prevent the skeletal complications of prostate cancer. Current research efforts will determine the magnitude of bone loss in men with prostate cancer, evaluate the effectiveness of several treatment strategies, and investigate the mechanisms of treatment-related bone loss. Related research efforts include evaluation of the effects of gonadal steroid deprivation on body composition, including muscle size and strength.


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