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F. Stephen Hodi, MD

Associate Professor, Department of Medicine, Harvard Medical School

Assistant Professor of Medicine, DF/HCC, Dana-Farber Cancer Institute

Contact Info

F. Stephen Hodi
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Phone: 617-632-5053
Fax: 617-582-7992
Stephen_Hodi@dfci.harvard.edu

Assistant

Natacha Hyacinthe
Administrative Assistant
DF/HCC
Dana-Farber Cancer Institute
44 Binney Street
Boston, MA, 02115
Phone: 617-632-4715
Fax: 617-582-7992
Natacha_Hyacinthe@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Immunology
Cutaneous Oncology and Melanoma, Co-Leader

DF/HCC Associations

Member, Center Scientific Council
Member, Clinical Science Coordinating Committee

Research Abstract

We performed a clinical trial of vaccination with lethally irradiated, autologous melanoma cells expressing human GM-CSF. Vaccination elicits a striking infiltrate of pre-existing metastatic lesions with large numbers of lymphocytes, plasma cells, macrophages, and eosinophils, resulting in tumor destruction, fibrosis and edema. From this foundation we are determining the melanoma antigens that have stimulated specific T and B cell responses in vaccinated patients through molecular analyses.

Publications

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