DF/HCC Program Affiliation

Cancer Immunology
Cutaneous Oncology and Melanoma

Research Abstract

We performed a clinical trial of vaccination with lethally irradiated, autologous melanoma cells expressing human GM-CSF. Vaccination elicits a striking infiltrate of pre-existing metastatic lesions with large numbers of lymphocytes, plasma cells, macrophages, and eosinophils, resulting in tumor destruction, fibrosis and edema. From this foundation we are determining the melanoma antigens that have stimulated specific T and B cell responses in vaccinated patients through molecular analyses.

Publications

• Jinushi M, Hodi FS, Dranoff G.Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity.Proc Natl Acad Sci U S A 2006 Jun 5.
  16754847
• Hodi FS, Dranoff G.Combinatorial cancer immunotherapy.Adv Immunol 2006;90:341-68.
  16730268
• Hodi FS, Dranoff G.Genetically modified tumor cell vaccines.Surg Oncol Clin N Am 1998 Jul;7(3):471-85.
  9624213
• Haluska FG, Hodi FS.Molecular genetics of familial cutaneous melanoma.J Clin Oncol 1998 Feb;16(2):670-82.
  9469357