DF/HCC Program Affiliation

Gastrointestinal Malignancies

Research Abstract

The long-term objectives of this ongoing project is to elucidate the molecular mechanisms which govern the processes of growth and differentiation within the intestinal epithelia. We are particularly interested in understanding the mechanisms involved in normal crypt-villus enterocyte differentiation, as well as those factors which go awry in a number of gut disease states, including inflammatory conditions, prolonged starvation, systemic trauma and sepsis. as well as cancer. Another project is designed to unravel the molecular mechanisms by which thyroid hormone exerts its profound effects on enterocyte growth and differentiation.

Publications

• Kaplan GG, McCarthy EP, Ayanian JZ, Korzenik J, Hodin R, Sands BE.Impact of Hospital Volume on Postoperative Morbidity and Mortality Following a Colectomy for Ulcerative Colitis.Gastroenterology 2008 Jan 10.
  18242604
• Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA.Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas.Arch Surg 2007 Apr;142(4):381-6.
  17441292
• Malo MS, Biswas S, Abedrapo MA, Yeh L, Chen A, Hodin RA.The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression.DNA Cell Biol 2006 Dec;25(12):684-95.
  17233117
• Malo MS, Mozumder M, Zhang XB, Biswas S, Chen A, Bai LC, Merchant JL, Hodin RA.Intestinal alkaline phosphatase gene expression is activated by ZBP-89.Am J Physiol Gastrointest Liver Physiol 2006 Apr;290(4):G737-46.
  16384873
• Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, Abedrapo MA, Chen X, Yang VW, Hodin RA.Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.Am J Physiol Gastroint
  12919939
• Archer SY, Hodin RA.Histone acetylation and cancer.Curr Opin Genet Dev 1999 Apr;9(2):171-4.
  10322142
• Kim JH, Meng S, Shei A, Hodin RA.A novel Sp1-related cis element involved in intestinal alkaline phosphatase gene transcription.Am J Physiol 1999 Apr;276(4 Pt 1):G800-7.
  10198321
• Archer SY, Meng S, Shei A, Hodin RA.p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells.Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6791-6.
  9618491