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Raju Kucherlapati, PhD

Paul C. Cabot Professor, Department of Genetics, Harvard Medical School

Professor, Department of Medicine, Harvard Medical School

Scientific Director, Harvard-Partners Center for Genetics and Genomics, Partners HealtheCare System, Brigham And Women's Hospital

Contact Info

Raju Kucherlapati
Harvard Medical School
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: NRB, Suite 250
Phone: 617-525-4445
Fax: 617-525-4440


Veronica El-Dayisty
Administrative Assistant
Harvard Medical School
77 Avenue Louis Pasteur
Boston, MA, 02115
Phone: 617-525-4446
Fax: 617-525-4440

DF/HCC Program Affiliation

Cancer Genetics
Gastrointestinal Malignancies

Research Abstract

We are involved in generating mouse models for human cancer and studying the roles of genes implicated in cancer initiation and progression. We use gene targeting to generate genetically modified mice. We have made mice with mutations in Apc, Mcc, N-ras, Smad2, Smad4, Msh2, Msh3, Msh4, Msh5, Msh6 and Mlh1. Many of these mice are predisposed to develop cancer at a number of anatomical sites, most frequently in the gastrointestinal tract. Some of these mice individually or in combinations are excellent models for familial adenomatous polyposis (FAP) and hereditary non-polyposis colon cancer (HNPCC). We are currently examining the role of a number of other genes in the initiation and progression of a number of cancers with emphasis on gastrointestinal cancer.


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