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Joseph G. Sodroski, MD

Professor, Department of Microbiology and Immunobiology, Harvard Medical School

Professor, Department of Immunology and Infectious Diseases, Harvard School Of Public Health

Associate Director, Harvard Medical School Center for AIDS Research, Dana-Farber Cancer Institute

Contact Info

Joseph Sodroski
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: JFB 824
Phone: 617-632-3371
Fax: 617-632-4338
joseph_sodroski@dfci.harvard.edu

Assistant

Yvette McLaughlin
Administrative Assistant
DFCI/BIDMC/CH Center for AIDS Research
Dana-Farber Cancer Institute
44 Binney Street
Boston, MA, 02115
Phone: 617-632-4351
Fax: 617-632-3113
yvette_mclaughlin@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

Major interests of the laboratory are human immunodeficiency virus entry and pathogenesis. Central to both of these processes are the viral envelope glycoproteins, which mediate the binding and fusion of the virus with the target cell and the cytopathic effects of infection. The laboratory is devoted to understanding how virus entry occurs at the molecular level and how neutralizing antibodies interfere with virus entry. Means of eliciting neutralizing antibodies with broader reactivity are being explored. The mechanisms of viral cytopathic effects and the contribution of these processes to CD4 lymphocyte depletion in vivo are being studied.

Another interest of the laboratory is the species-specific block to HIV-1 that operates after virus entry. A component of cytoplasmic bodies, TRIM5α, blocks HIV-1 in Old World monkey cells. Human TRIM5α also exhibits anti-HIV-1 activity, but this is less potent than the monkey orthologue. The mechanism of action and the role of species-specific and individual variation in TRIM5α in virus resistance are being explored.

Publications

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