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Bernhard Kuhn, MD

Assistant Professor, Department of Pediatrics, Harvard Medical School

Assistant, Cardiology, Boston Children's Hospital

Contact Info

Bernhard Kuhn
Boston Children's Hospital
300 Longwood Ave
Boston, MA, 02115
Mailstop: Enders 1261
Phone: 617-919-4712
Fax: 617-731-0787
bkuhn@enders.tch.harvard.edu

Assistant

Carmen Popovici
Administrative Assistant
Pediatrics
Harvard Medical School
300 Longwood Ave
Boston, MA, 02115
Phone: 617-919-2681
Fax: 617-731-0787
Carmen.Popovici@childrens.harvard.edu

DF/HCC Program Affiliation

Cancer Genetics

Research Abstract

Cardiomyocytes are the contractile cells of the heart. Cardiomyocytes proliferate during development. In the adult heart, it is generally believed that the majority of cardiomyocytes do not proliferate. This view is supported in part by the lack of significant myocardial regeneration. Furthermore, primary myocardial tumors are rare in adults.
However, some cardiomyocytes in the adult heart can re-enter the cell cycle. Our work addresses important biological questions: Can differentiated contractile cardiomyocytes proliferate? What regulates the cardiomyocyte cell cycle?
Inducing cardiomyocyte proliferation may provide an innovative strategy to enhance the regenerative capacity of mammalian hearts. Understanding the mechanisms of the tight proliferative arrest of the majority of adult cardiomyocytes may provide a clue to the virtual absence of myocardial tumors.

Publications

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