October 17, 2018

Fall 2018 Publication Mixtape

Here is a selection of recent collaborative publications involving DF/HCC authors for your reading pleasure.

Mutational processes shape the landscape of TP53 mutations in human cancer.
Nat Genet. 2018 Oct
Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, Doench JG, Piccioni F, Roberts CWM, Meyerson M (DFCI), Getz G (MGH), Johannessen CM, Root DE, Hahn WC (DFCI).
PMID: 30224644

Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.
Proc Natl Acad Sci USA. 2018 Oct 2
Li BB, Qian C, Gameiro PA, Liu CC, Jiang T, Roberts TM (DFCI), Struhl K (HMS), Zhao JJ (DFCI).
PMID: 30224479.

Parp3 promotes long-range end joining in murine cells.
Proc Natl Acad Sci USA. 2018 Oct 2
Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R (BCH), Alt FW (BCH), Roberts SA, Weinstock DM (DFCI), Day TA.
PMID: 30213852.

Inhibition of cIAP1 as a strategy for targeting c-MYC-driven oncogenic activity.
Proc Natl Acad Sci USA. 2018 Oct 2
Li H, Fang Y, Niu C, Cao H, Mi T, Zhu H, Yuan J (HMS), Zhu J.
PMID: 30181285.

Mechanisms of acquired resistance to rapalogs in metastatic renal cell carcinoma.
PLoS Genet. 2018 Sep 26
Hamieh L, Choueiri TK (DFCI), Ogórek B, Khabibullin D, Rosebrock D, Livitz D, Fay A, Pignon JC, McDermott DF (BIDMC), Agarwal N, Gao W, Signoretti S (BWH), Kwiatkowski DJ (BWH).
PMID: 30256787.

Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
Cell Rep. 2018 Sep 25
Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K (DFCI), Walensky LD (DFCI).
PMID: 30257201.

Perceptions of Oncologists About Sharing Clinic Notes with Patients.
Oncologist. 2018 Sep 25
McCleary NJ (DFCI), Healey MJ, Weng S, Song AB, Lederman RI, Ramelson HZ, Wagner AJ (DFCI), Abel GA (DFCI).
PMID: 30254186.

BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.
Nat Med. 2018 May 28
Li AG, Murphy EC, Culhane AC (DFCI), Powell E, Wang H, Bronson RT (HMS), Von T, Giobbie-Hurder A, Gelman RS (DFCI), Briggs KJ, Piwnica-Worms H, Zhao JJ (DFCI), Kung AL, Kaelin WG Jr (DFCI), Livingston DM (DFCI).
PMID: 30254159.

Needle in a Haystack: Natural Language Processing to Identify Serious Illness.
J Palliat Med. 2018 Sep 22
Udelsman B, Chien I, Ouchi K, Brizzi K, Tulsky JA (DFCI), Lindvall C (DFCI).
PMID: 30251922.

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy.
J Clin Oncol. 2018 Sep 21
Cruz C, Llop-Guevara A, Garber JE (DFCI), Arun BK, Pérez Fidalgo JA, Lluch A, Telli ML, Fernández C, Kahatt C, Galmarini CM, Soto-Matos A, Alfaro V, Pérez de la Haza A, Domchek SM, Antolin S, Vahdat L, Tung NM (BIDMC), Lopez R, Arribas J, Vivancos A, Baselga J, Serra V, Balmaña J, Isakoff SJ (MGH).
PMID: 30240327.

Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions.
Breast Cancer Res Treat. 2018 Sep 20
Acevedo F, Armengol VD, Deng Z, Tang R, Coopey SB, Braun D, Yala A, Barzilay R, Li C, Colwell A (MGH), Guidi A, Cetrulo CL Jr (MGH), Garber J (DFCI), Smith BL (MGH), King T, Hughes KS (MGH).
PMID: 30238276.

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
Cell. 2018 Sep 20
McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC (HMS), Looper RE, Ligon KL (DFCI), Bernstein BE (MGH), Carrasco RD (DFCI), Cahill DP (MGH), Asara JM (BIDMC), Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr (DFCI).
PMID: 30220459.

mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
Nature. 2018 Sep
Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE (DFCI), Richards WG (BWH), Wong KK, Locker N, Slack FJ (BIDMC), Gregory RI.
PMID: 30232453.

Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-Mutant Lung Cancer.
Clin Cancer Res. 2018 Sep 17
Dagogo-Jack I, Martinez P, Yeap BY (MGH), Ambrogio C, Ferris LA, Lydon C, Nguyen T,  Jessop NA, Iafrate AJ (MGH), Johnson BE (DFCI), Lennerz JK, Shaw AT (MGH), Awad MM (DFCI).
PMID: 30224342.

Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour.
Eur J Cancer. 2018 Sep 12
Hamada T, Liu L, Nowak JA, Mima K, Cao Y (MGH), Ng K (DFCI), Twombly TS, Song M (MGH), Jung S, Dou R, Masugi Y, Kosumi K, Shi Y (BCH), da Silva A, Gu M, Li W, Keum N, Wu K (HSPH), Nosho K, Inamura K, Meyerhardt JA (DFCI), Nevo D, Wang M (HSPH), Giannakis M, Chan AT (MGH), Giovannucci EL (HSPH), Fuchs CS, Nishihara R (DFCI), Zhang X (BWH), Ogino S (DFCI).
PMID: 30219720.

Genotype-targeted local therapy of glioma.
Proc Natl Acad Sci USA. 2018 Sep 4
Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT (MGH), Brastianos PK (MGH), Curry WT Jr (MGH), Barker FG 2nd (MGH), Jordan JT, Iafrate AJ (MGH), Chi AS, Lennerz JK, Meyerson M (DFCI), Langer R, Wakimoto H (MGH), Traverso G, Cahill DP (MGH).
PMID: 30082399.

Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids.
Cancer Discov. 2018 Sep 13
Hill SJ, Decker B, Roberts EA, Horowitz NS (BWH), Muto MG (BWH), Worley MJ, Feltmate CM (BWH), Nucci MR (BWH), Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT (DFCI), Konstantinopoulos PA (DFCI), Liu JF (DFCI), Bonventre JV (BWH), Matulonis UA (DFCI), Shapiro GI (DFCI), Berkowitz RS (BWH), Crum CP (BWH), D'Andrea AD (DFCI).
PMID: 30213835.

A Phase II and Biomarker Study of Sorafenib Combined with FOLFOX in Patients with Advanced Hepatocellular Carcinoma (HCC).
Clin Cancer Res. 2018 Sep 6
Goyal L, Zheng H (MGH), Abrams TA, Miksad R, Bullock AJ (BIDMC), Allen JN, Yurgelun MB (DFCI), Clark JW (DFCI), Kambadakone A, Muzikansky A, Knowles M, Galway A, Afflitto AJ, DiNicola CF, Regan E, Hato T, Mamessier E, Shigeta K, Jain RK (MGH), Duda DG (MGH), Zhu AX (MGH).
PMID: 30190369.

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq.
Nat Commun. 2018 Sep 4
Karaayvaz M, Cristea S, Gillespie SM, Patel AP, Mylvaganam R, Luo CC, Specht MC (MGH), Bernstein BE (MGH), Michor F (DFCI), Ellisen LW (MGH).
PMID: PMC6123496.

tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish.
Elife. 2018 Sep 7
Ignatius MS, Hayes MN, Moore FE, Tang Q, Garcia SP, Blackburn PR, Baxi K, Wang L, Jin A, Ramakrishnan A, Reeder S, Chen Y, Nielsen GP, Chen EY, Hasserjian RP (MGH), Tirode F, Ekker SC, Langenau DM (MGH).
PMID: 30192230.

Addition of a polygenic risk score, mammographic density, and endogenous hormones to existing breast cancer risk prediction models: A nested case-control study.
PLoS Med. 2018 Sep 4
Zhang X (BWH), Rice M (BWH), Tworoger SS, Rosner BA (BWH), Eliassen AH (BWH), Tamimi RM (BWH), Joshi AD, Lindstrom S, Qian J, Colditz GA, Willett WC (HSPH), Kraft P (HSPH), Hankinson SE (BWH).
PMID: 30180161.

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization.
Nat Cell Biol. 2018 Sep
Castaño Z, San Juan BP, Spiegel A, Pant A, DeCristo MJ, Laszewski T, Ubellacker JM, Janssen SR, Dongre A, Reinhardt F, Henderson A, Del Rio AG, Gifford AM, Herbert ZT, Hutchinson JN, Weinberg RA, Chaffer CL, McAllister SS (BWH).
PMID: 30154549.

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors.
Nat Genet. 2018 Sep
Miao D, Margolis CA, Vokes NI, Liu D, Taylor-Weiner A, Wankowicz SM, Adeegbe D, Keliher D, Schilling B, Tracy A, Manos M, Chau NG, Hanna GJ, Polak P, Rodig SJ (BWH), Signoretti S (BWH), Sholl LM (BWH), Engelman JA, Getz G (MGH), Jänne PA (DFCI), Haddad RI (DFCI), Choueiri TK (DFCI), Barbie DA (DFCI), Haq R (DFCI), Awad MM (DFCI), Schadendorf D, Hodi FS (DFCI), Bellmunt J, Wong KK, Hammerman P, Van Allen EM (DFCI).
PMID: 30150660.

Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Proc Natl Acad Sci USA. 2018 Sep 11
Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D (MGH), McDannold N (BWH), Jain RK (MGH).
PMID: 30150398.

Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.
Genes Dev. 2018 Sep 1
Liao S, Maertens O, Cichowski K (BWH), Elledge SJ (HMS).
PMID: 30135075.