June 1, 2018

Monthly Publications Mixtape

Here is a selection of recent collaborative publications involving DF/HCC authors for your reading pleasure.

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Nat Med. 2018 May 28
Wong GS, Zhou J (BIDMC), Liu JB, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen  K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R (DFCI), Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ (DFCI).
PMID: 29808010.

Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.
Nat Commun. 2018 May 25;9(1):2068
Ji Z, He L, Rotem A, Janzer A, Cheng CS, Regev A, Struhl K (HMS).
PMCID: PMC5970197.

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.
Nat Commun. 2018 May 22;9(1):2024.
Ng SY, Yoshida N, Christie AL, Ghandi M, Dharia NV, Dempster J, Murakami M, Shigemori K, Morrow SN, Van Scoyk A, Cordero NA, Stevenson KE, Puligandla M, Haas B, Lo C, Meyers R, Gao G, Cherniack A, Louissaint A Jr (MGH), Nardi V, Thorner AR, Long H, Qiu X,Morgan EA (BWH), Dorfman DM (BWH), Fiore D, Jang J, Epstein AL, Dogan A, Zhang Y (BCH), Horwitz SM, Jacobsen ED, Santiago S, Ren JG, Guerlavais V, Annis DA, Aivado M, Saleh MN, Mehta A, Tsherniak A, Root D, Vazquez F, Hahn WC (DFCI), Inghirami G, Aster JC (BWH), Weinstock DM (DFCI), Koch R.
PMID:PMC5964252.

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
Cancer Cell. 2018 May 15.
Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT (HMS), Deraedt T, Cichowski K (BWH), Welm AL, Mori Y, Mills GB, Brugge JS (HMS).
PMID: 29805077.

Structural Basis of Smoothened Activation in Hedgehog Signaling.
Cell. 2018 May 15.
Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J (DFCI), Kruse AC, Salic A (HMS).
PMID: 29804838.

Medical Oncologists' Beliefs, Practices, and Knowledge Regarding Marijuana Used Therapeutically: A Nationally Representative Survey Study.
J Clin Oncol. 2018 May 10
Braun IM (DFCI), Wright A (DFCI), Peteet J (BWH), Meyer FL, Yuppa DP, Bolcic-Jankovic D, LeBlanc J, Chang Y, Yu L, Nayak MM, Tulsky JA (DFCI), Suzuki J, Nabati L, Campbell EG.
PMID: 29746226.

Safety of Programmed Death-1 Pathway Inhibitors Among Patients With Non-Small-Cell Lung Cancer and Preexisting Autoimmune Disorders.
J Clin Oncol. 2018 May 10
Leonardi GC, Gainor JF (MGH), Altan M, Kravets S, Dahlberg SE (DFCI), Gedmintas L, Azimi R, Rizvi H, Riess JW, Hellmann MD, Awad MM (DFCI).
PMID: 29746230.

Quantification of Long-term Survival Benefit in a Comparative Oncology Clinical Study.
JAMA Oncol. 2018 May 3.
Horiguchi M, Tian L, Uno H (DFCI), Cheng S, Kim DH, Schrag D (DFCI), Wei LJ (DFCI).
PMID:29801103.

Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair.
Nat Commun. 2018 May 1
Haradhvala NJ, Kim J (HSPH), Maruvka YE, Polak P, Rosebrock D, Livitz D, Hess JM, Leshchiner I, Kamburov A, Mouw KW (DFCI), Lawrence MS, Getz G (MGH).
PMID: PMC5931517.

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.
Nat Med. 2018 May.
Chapuy B, Stewart C, Dunford AJ, Kim J (HSPH), Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML (DFCI), Golub TR (DFCI), Beroukhim R (DFCI), Wulf GG (BIDMC), Ott G, Rodig SJ (BWH), Monti S, Neuberg DS (DFCI), Loeffler M, Pfreundschuh M, Trümper L, Getz G (MGH), Shipp MA (DFCI).
PMID: 29713087.

Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma.
Nat Commun. 2018 Apr 27
Manier S, Park J (MGH), Capelletti M, Bustoros M, Freeman SS, Ha G, Rhoades J, Liu CJ, Huynh D, Reed SC, Gydush G, Salem KZ, Rotem D, Freymond C, Yosef A, Perilla-Glen A, Garderet L, Van Allen EM (DFCI), Kumar S, Love JC, Getz G (MGH), Adalsteinsson VA, Ghobrial IM (DFCI).
PMID: PMC5923255.

Comprehensive Genomic Profiling of Metastatic Tumors in a Phase 2 Biomarker Study of Everolimus in Advanced Renal Cell Carcinoma.
Clin Genitourin Cancer. 2018 Apr 25.
Gao X, Jegede O, Gray C, Catalano PJ (DFCI), Novak J, Kwiatkowski DJ (BWH), McKay RR, George DJ, Choueiri TK (DFCI), McDermott DF (BIDMC), Signoretti S (BWH), Bhatt RS (BIDMC).
PMID: 29754934.

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity.
Science. 2018 Mar 30
Ferrari de Andrade L, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF Jr, Harvey CJ, Kobold S, Pyrdol JW, Yoon C, Yuan GC (DFCI), Hodi FS (DFCI), Dranoff G, Wucherpfennig KW (DFCI).
PMID: 29599246.

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
Science. 2018 Mar 23.
Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC (BCH), Taghian AG (MGH), Padera TP.
PMID: 29567713.

The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.
Cell Metab. 2018 Mar 16.
Tang HW, Hu Y, Chen CL, Xia B, Zirin J, Yuan M, Asara JM (BIDMC), Rabinow L, Perrimon N (HMS).
PMID: 29606597.

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Sci Transl Med. 2018 Mar 14.
Incio J, Ligibel JA (DFCI), McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM (DFCI), Krop IE (DFCI), Duda DG (MGH), Boucher Y, Fukumura D (MGH), Jain RK (MGH).
PMID: 29540614.

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.
Mol Cell. 2018 Mar 1.
Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC (HMS), Opferman JT, Walensky LD (DFCI).
PMID: 29499131.