Quarterly Publication Mixtape

March 2018,

Here is a selection of recent collaborative publications involving DF/HCC authors for your reading pleasure.

March

Genomic and functional fidelity of small cell lung cancer patient-derived xenografts.
Cancer Discov. 2018 Feb 26
Drapkin BJ, George J, Christensen CL, Mino-Kenudson M (MGH), Dries R, Sundaresan T, Phat S, Myers DT, Zhong J, Igo P, Hazar-Rethinam MH, LiCausi JA, Gomez-Caraballo M, Kem M, Jani KN, Azimi R, Abedpour N, Menon R, Lakis S, Heist RS (MGH), Büttner R, Haas S, Sequist LV (MGH), Shaw AT (MGH), Wong KK, Hata AN (MGH), Toner M, Maheswaran S (MGH), Haber DA (MGH), Peifer M, Dyson N (MGH), Thomas RK, Farago AF (MGH).
PMID: 29483136.

Breast Cancer Diagnosis and Treatment After High-Deductible Insurance Enrollment.
 J Clin Oncol. 2018 Feb 28
Wharam JF (HMS), Zhang F, Lu CY, Wagner AK, Nekhlyudov L (HMS), Earle CC, Soumerai SB, Ross-Degnan D (HMS).
PMID: 29489428.

Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma  and solid tumors.
Leukemia. 2018 Feb 22
Bae J, Hideshima T, Tai YT (DFCI), Song Y, Richardson P (DFCI), Raje N (MGH), Munshi NC (DFCI), Anderson KC (DFCI).
PMID: 29487385.

Multiplexed Immunofluorescence Reveals Potential PD-1/PD-L1 Pathway Vulnerabilities in Craniopharyngioma.
Neuro Oncol. 2018 Mar 2
Coy S, Rashid R, Lin JR, Du Z, Donson AM, Hankinson TC (BWH), Foreman NK, Manley PE, Kieran MW (DFCI), Reardon DA (DFCI), Sorger PK (HMS), Santagata S (BWH).
PMID: 29509940.

Dissecting super-enhancer hierarchy based on chromatin interactions.
Nat Commun. 2018 Mar 5
Huang J, Li K, Cai W, Liu X (DFCI), Zhang Y (BCH), Orkin SH (DFCI), Xu J, Yuan GC (DFCI).
PMID: 29507293.

A First-in-Human Phase 1 Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers.
Oncologist. 2018 Mar 6
Tolcher A, Flaherty K (MGH), Shapiro GI (DFCI), Berlin J, Witzig T, Habermann T, Bullock A (BIDMC), Rock E, Elekes A, Lin C (MGH), Kostic D, Ohi N, Rasco D, Papadopoulos KP, Patnaik A, Smith L, Cote GM (MGH).
PMID: 29511132.

Toxicity and efficacy of a novel GADD34-expressing oncolytic HSV-1 for the treatment of experimental glioblastoma.
Clin Cancer Res. 2018 Mar 6
Nakashima H, Nguyen T, Kasai K, Passaro C, Ito H, Goins WF, Shaikh I, Erdelyi R, Nishihara R (DFCI), Nakano I, Reardon DA (DFCI), Anderson AC, Kuchroo V (BWH), Chiocca EA (BWH).
PMID: 29511029.

Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Sci Transl Med. 2018 Mar 7
Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ (DFCI), Stone RM (DFCI), Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein  AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K (DFCI), Holson EB.
PMID: 29515000.

Anxiety and Depression in Young Women With Metastatic Breast Cancer: A Cross-Sectional Study.
Psychosomatics. 2018 Jan 31
Park EM, Gelber S, Rosenberg SM (DFCI), Seah DSE, Schapira L, Come SE (BIDMC), Partridge AH (DFCI).
PMID: 29525523.

Tobacco treatment implementation within 28 commission on cancer accredited programs in the Northeast region of the USA: A pilot study.
Transl Behav Med. 2018 Mar 8
Cooley ME (DFCI), Poghosyan H, Sprunck-Harrild K, Winickoff JP (MGH), Edge SB, Emmons KM.
PMID: 29528457.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Sci Adv. 2018 Mar 7
Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S (BWH), Yang K, Nakano I, Lee H, Weissleder R (MGH), Breakefield XO (MGH), Godlewski J, Westphal M, Lamszus K, Freeman GJ (DFCI), Bronisz A, Lawler SE, Chiocca EA (BWH).
PMCID: PMC5842038.

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.
Nat Cell Biol. 2018 Mar 12
Gutierrez-Martinez P, Hogdal L, Nagai M, Kruta M, Singh R, Sarosiek K, Nussenzweig A, Beerman I, Letai A (DFCI), Rossi DJ.
PMID: 29531308.

Preliminary results for avelumab plus axitinib as first-line therapy in patients with advanced clear-cell renal-cell carcinoma (JAVELIN Renal 100): an open-label, dose-finding and dose-expansion, phase 1b trial.
Lancet Oncol. 2018 Mar 9
Choueiri TK (DFCI), Larkin J, Oya M, Thistlethwaite F, Martignoni M, Nathan P, Powles T, McDermott D (BIDMC), Robbins PB, Chism DD, Cho D, Atkins MB, Gordon MS, Gupta S, Uemura H, Tomita Y, Compagnoni A, Fowst C, di Pietro A, Rini BI.
PMID: 29530667.

February

Network analysis of UBE3A/E6AP-associated proteins provides connections to several distinct cellular processes.
J Mol Biol. 2018 Feb 6.
Martínez-Noël G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan JT, Rodriguez D, Zheng L, Boyland K, Leclere F, Zhong Q, Hill DE, Vidal M(DFCI) , Howley PM (HMS).
PMID: 29426014.

Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine.
Gut. 2018 Feb 6.
Ogino S (DFCI), Nowak JA, Hamada T, Phipps AI, Peters U, Milner DA Jr, Giovannucci EL (HSPH), Nishihara R(DFCI), Giannakis M, Garrett WS (HSPH), Song M (MGH).
PMID: 29437869.

Durable clinical benefit in metastatic renal cell carcinoma patients who discontinue PD-1/PD-L1 therapy for immune-related adverse events (irAEs).
Cancer Immunol Res. 2018 Feb 1.
Martini DJ, Hamieh L, McKay RR, Harshman LC (DFCI), Brandao R, Norton CK, Steinharter JA, Krajewski KM (BWH), Gao X, Schutz FA, McGregor B (DFCI), Bosse D, Lalani AK, de Velasco G, Michaelson MD (MGH), McDermott DF (BIDMC), Choueiri TK (DFCI).   
PMID: 29437040.

Convergent therapeutic strategies to overcome the heterogeneity of acquired resistance in BRAFV600E colorectal cancer. 
Cancer Discov. 2018 Feb 5.
Hazar-Rethinam M, Kleyman M, Han GC, Liu D, Ahronian LG, Shahzade HA, Chen L, Parikh AR, Allen JN, Clark JW (MGH), Kwak EL, Faris JE, Murphy JE, Hong TS (MGH), Van Seventer EE, Nadres B, Hong CB, Gurski JM, Jessop NA, Dias-Santagata D, Iafrate AJ (MGH), Van Allen EM (DFCI), Corcoran RB (MGH). 
PMID: 29431697.

Insurance status and cancer treatment mediate the association between race/ethnicity and cervical cancer survival. 
PLoS One. 2018 Feb 15
Markt SC, Tang T, Cronin AM, Katz IT (BWH), Howitt BE, Horowitz NS (BWH), Lee LJ, Wright AA (DFCI). 
PMID: 29447263.

Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs. 
Cancer Immunol Res. 2018 Feb 19.
Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH(HMS), Ploegh HL,Dougan SK (DFCI). 
PMID: 29459478.

"I don't want to take chances.": A qualitative exploration of surgical decision making in young breast cancer survivors.
Psychooncology. 2018 Feb 24.
Rosenberg SM (DFCI), Greaney ML, Patenaude AF, Sepucha KR (MGH), Meyer ME, Partridge AH (DFCI).  
PMID: 29476578.

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. 
Cancer Cell. 2018 Feb 12
Iniguez AB, Stolte B, Wang EJ, Conway AS, Alexe G, Dharia NV, Kwiatkowski N, Zhang T, Abraham BJ, Mora J, Kalev P, Leggett A, Chowdhury D (DFCI), Benes CH, Young RA, Gray NS (DFCI), Stegmaier K (DFCI). 
PMID: 29358035.

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.
Cell. 2018 Feb 8
Ambrogio C, Köhler J, Zhou ZW, Wang H (BIDMC), Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R (BCH), Santamaría D, Westover KD, Jänne PA(DFCI).  
PMID: 29336889.

January

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.
Cell. 2018 Jan 11.
Hoggatt J (MGH), Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV (HMS), Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT (MGH), Pelus LM.
PMID: 29224778

Fiber Intake and Survival After Colorectal Cancer Diagnosis.
JAMA Oncol. 2018 Jan 1.
Song M (MGH), Wu K (HSPH), Meyerhardt JA (DFCI), Ogino S (DFCI), Wang M (HSPH), Fuchs CS, Giovannucci EL (HSPH), Chan AT (MGH).
PMCID: PMC5776713

Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation. 
J Clin Oncol. 2017 Dec 20.
Soiffer RJ (DFCI), Kim HT (DFCI), McGuirk J, Horwitz ME, Johnston L, Patnaik MM, Rybka W, Artz A, Porter DL, Shea TC, Boyer MW, Maziarz RT, Shaughnessy PJ, Gergis U, Safah H, Reshef R, DiPersio JF, Stiff PJ, Vusirikala M, Szer J, Holter J, Levine JD (BIDMC), Martin PJ, Pidala JA, Lewis ID, Ho VT (DFCI), Alyea EP (DFCI), Ritz J(DFCI), Glavin F, Westervelt P, Jagasia MH, Chen YB (MGH).
PMID: 29040031

Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer.
Nat Commun. 2017 Dec 19.
Liu D, Abbosh P, Keliher D, Reardon B, Miao D, Mouw K (DFCI), Weiner-Taylor A, Wankowicz S, Han G, Teo MY, Cipolla C, Kim J, Iyer G, Al-Ahmadie H, Dulaimi E, Chen DYT, Alpaugh RK, Hoffman-Censits J, Garraway LA (DFCI), Getz G (MGH), Carter SL (DFCI), Bellmunt J (DFCI), Plimack ER, Rosenberg JE, Van Allen EM (DFCI).
PMCID: PMC5736752

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy. 
Nat Commun. 2017 Dec 19.
Landau DA, Sun C, Rosebrock D, Herman SEM, Fein J, Sivina M, Underbayev C, Liu D, Hoellenriegel J, Ravichandran S, Farooqui MZH, Zhang W, Cibulskis C, Zviran A, Neuberg DS (DFCI), Livitz D, Bozic I, Leshchiner I, Getz G (MGH), Burger JA, Wiestner A, Wu CJ (DFCI).
PMCID: PMC5736707

First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study.
Cancer Discov. 2017 Dec 15.
Sullivan RJ (MGH), Infante JR, Janku F, Wong DJL, Sosman JA, Keedy V, Patel MR, Shapiro GI (DFCI), Mier JW (BIDMC), Tolcher AW, Wang-Gillam A, Sznol M, Flaherty K (MGH), Buchbinder E (DFCI), Carvajal RD, Varghese AM, Lacouture ME, Ribas A, Patel SP, DeCrescenzo GA, Emery CM, Groover AL, Saha S, Varterasian M, Welsch DJ, Hyman DM, Li BT.
PMID: 29247021

The Impact of Smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations - the Lung Cancer Mutation Consortium (LCMC2).
Clin Cancer Res. 2017 Dec 7.
Aisner DL, Sholl LM (BWH), Berry L, Rossi M, Chen H, Fujimoto J, Moreira AL, Ramalingam S, Villaruz LC, Otterson GA, Haura EB, Politi K, Glisson BS, Cetnar J, Garon E, Schiller J, Waqar S, Sequist LV (MGH), Brahmer JR, Shyr Y, Kugler K, Wistuba II, Johnson BE (DFCI), Minna JD, Kris MG, Bunn PA, Kwiatkowski DJ (BWH).
PMID: 29217530

Aging and neurodegeneration are associated with increased mutations in single human neurons.
Science. 2017 Dec 7.
Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava C, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ (HMS), Walsh CA (BCH).
PMID: 29217584