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Due Date Extended: Bridge Project- Pancreatic Cancer or Glioblastoma Research Proposals

Due Date for Proposal Submission extended to November 7, 2011


Award Amount: $325,000 (total costs) per team project per year for up to 2 years. We anticipate that up to two awards will be made in this cycle with the possibility for more depending on ongoing fundraising efforts.

Letter of Intent Due: September 22, 2011

Proposal Submission Date: (*Updated*) November 7, 2011

Finalist(s) present to Bridge Review Team: mid-November, 2011

Project Start Date: no later than June 1, 2012

Submission Information: LOIs and applications should be submitted electronically as a single PDF file to:

W. David Lee (wdlee@mit.edu) and,

Sarah Weiler (sweiler1@partners.org)

Overview and Goal of the Bridge Project

The Koch Institute (KI)-Dana-Farber/Harvard Cancer Center (DF/HCC) Bridge Project is designed to help bring the expertise of these two Centers to bear on complex translational problems in cancer research. A particular emphasis is placed on fostering joint approaches by engineers and cancer scientists, both basic and clinical/translational. This is a call for applications for collaborative research projects that focus on critical problems in glioblastoma and pancreatic cancer. Additional information on the Bridge Project including faculty presentations on unmet clinical needs and technology can be found at: https://wikis.mit.edu/confluence/display/BRIDGEPROJECT/


All applications must be from a team composed of at least one member of Koch Institute and one member of DF/HCC. Teams with more than two PIs are welcomed. Each PI must meaningfully participate in the project. Preference will be given to teams that are employing unique and highly innovative approaches, including the development of new technologies, to advance pancreatic and glioblastoma research. All applicants must be faculty members (greater than or equal to assistant professor) of their host institution.

Letter of Intent (due September 22)

Submission of a Letter of Intent is required. It should include the names of the PIs, briefly describe the project, and indicate the major experimental approaches that will be employed. Letters of Intent should not exceed two pages. Letters of Intent should be submitted electronically to both:W. David Lee (wdlee@mit.edu) and Sarah Weiler (sweiler1@partners.org).

Proposal Submission Information (due November 1st)

The research proposal may not exceed four pages including figures and tables. Cover page, biosketches, budgets, and one page of literature citations do not count to the page limit.

* Format

• 12 point Cambria or Arial font and margins of 0.5 inches or greater

• Required Componentso Cover Page. Include the title of the project, PIs names, and project abstract (~250 words)

o NIH Biosketches for each PI. Include Part A (Personal Statement), which should include a description of the PI’s role on the project

o Budgets and Budget Justifications. Using PHS 398 form pages, submit one per institution with additional overall budget for the project Research Plan. Include Background and Significance, Specific Aims, and the Research Plan

o Literature Citations

The research proposal should clearly articulate the following:

• What is the primary unmet medical need you are addressing?• What approaches do you intend to use and why are they novel?

• What are the anticipated experimental challenges?

• What are the short- and longer-term goals of the research?

• What can be reasonably accomplished within the funding period?

• What clinically translatable applications might emerge from this work now or in the future?

Resources and Budget

Funding for the project should be allocated in roughly equal amounts to the Koch Institute and to the DF/HCC institution(s). Budget requests and justifications must be submitted using PHS 398 form pages for each institution as well as an overall project budget for the full project period. Funds may be used for research expenses, which may include salary and benefits for PIs and other research staff, supplies, and equipment. MIT and DF/HCC will apply rates according to their established policies. Applicants should inquire with their grants administrators (DF/HCC administration for DF/HCC institutions) for additional information about applicable F&A rates. Funding may be requested for up to a two-year period, but the renewal at the end of year one is subject to performance review. Budgets are not to exceed $325,000 total costs (shared between the KI and the DF/HCC PI’s) per project per year.

Review Process

Letters of Intent and full applications will be reviewed by a panel of experts from the Koch Institute and DF/HCC plus ad hoc reviewers as appropriate. A group of finalists will beinvited to present their proposals to the Bridge Project Executive Team, who will make the final funding decision.

Progress Reports

Grantees must submit a progress report at the end of the first year of funding. Progress will be measured against stated benchmarks and timelines. Second year funding will be dependent on a satisfactory review of the Progress Report. Unanticipated scientific findings that delay research timelines will not exclude grantees from continued funding so long as grantee research is of a high caliber and is within the scope of the original research proposal.

Contact Information

Please direct questions to:

Tyler Jacks (tjacks@mit.edu)

David Livingston (David_Livingston@dfci.harvard.edu)

W. David Lee (wdlee@mit.edu)

Sarah Weiler (sweiler1@partners.org)