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PLCO Etiology and Early Marker Studies (EEMS) 2007 Review Cycle

To:     Potential EEMS Investigators

From:     EEMS Coordinating Center

Re:     PLCO Etiology and Early Marker Studies (EEMS)  2007  Review Cycle

Date:   January 5, 2007

This memo is an official announcement that the PLCO EEMS review process will be accepting proposals for use of the PLCO biorepository materials  twice for calendar year 2007.   Applications for the first round for 2007 with be June 1, 2007 through June 30, 2007 at 5 PM EDST.  The second round will be from December 1, 2007 through December 29, 2007 at 5 PM EST.  Another announcement will be sent eight weeks prior to the open season for receipt of applications.  We trust that this advance notice will allow you to plan more appropriately for your research activities this calendar year.  We plan to continue twice yearly rounds for application acceptance during the months of June and December if budgetary constraints allow.

Please distribute this notice to those individuals with whom you work that may be interested in submitting an EEMS application.

The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a large population based randomized trial evaluating screening programs for these cancers. The PLCO Biorepository contains approximately 2.7 million biologic specimens, including blood specimens collected from intervention participants during their six trial screening years and buccal cell specimens collected from control participants. The Etiology and Early Marker Studies (EEMS) is a component of the PLCO Trial designed to facilitate research in early detection and molecular epidemiology of cancers using Trial collection specimens.

The EEMS application materials ( the EEMS application forms, instructions, applicant's checklist, NIH biosketch, confidentiality disclosure agreement (CDA), and the EEMS policy document), as well as general information regarding the EEMS review process can be found under the PLCO EEMS tab on the Program Administrative Resource (PAR) PLCO website (www.parplco.org). Individuals who do not already have access to PAR should contact the PAR PLCO Helpdesk (parplcohelpdesk@westat.com) and request permission to access the EEMS tab on the website. Individuals who currently have access to PAR should already be able to access to the EEMS tab; please contact the PAR PLCO Helpdesk (parplcohelpdesk@westat.com) with any problems.

Once your proposal is received, the EEMS Coordinating Center will verify that all components are completed and forward the completed proposal packet to the EEMS Principal Investigator, the PLCO Project Officer and Chief Statistician for an initial suitability review. This initial review will be completed around the end of January 2007. Potential investigators will be notified of the results of the suitability review. After the suitability review, the EEMS Review Panel will review and comment on all suitable proposals.  It is anticipated that this review will be completed by mid-March 2007, contingent upon the quantity of proposals received.  The EEMS PI and the PLCO PO will then make the final decision regarding all acceptable proposals based on input from the EEMS Review Panel.

Please email your completed proposal application and associated materials to the EEMS Coordinating Center at the following address:


Any documents that require a signature should be sent to the following address:

EEMS Coordinating Center
1650 Research Blvd, TB206
Rockville, MD 20850

If you have any questions please do not hesitate to contact us.