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DF/HCC members receive Harvard Catalyst Pilot Grants

The Harvard Clinical and Translational Science Center is a university-wide collaborative effort committed to reducing the burden of human illness by helping researchers better leverage the human and technological resources of Harvard and its Academic Healthcare Centers. In addition to its education and training programs, support services for translational researchers, and research consultation services, Harvard Catalyst offers seed funds in the form of pilot grants to foster cross-institutional and cross-disciplinary collaboration. In the first year, Harvard Catalyst awarded $3.1 million in funding. This year, Harvard Catalyst anticipates awarding approximately 80 grants of $50,000 each. Below is a list of funded DF/HCC members and projects.

A Pilot Trial of Cytosine Deaminase-Expressing Mesenchymal Stromal Cells in Glioblastoma Therapy
Principal Investigator: Peter Black, MD, PhD (BWH)
Co-Investigators: Xandra Breakefield, PhD (MGH); Patrick Wen, MBBS (BWH)

Assessment of Biodistribution and Tissue Concentration of Lapatinib in Brain and Brain-metastases of Patients with HER2 Positive Early-stage and Metastatic Breast Cancer by Non-invasive Fluorine-19 Magnetic Resonance Spectroscopy In Vivo
Co-Investigator: Steven Isakoff, MD, PhD (MGH)

Validation and Development of the Serum Exosome Assay for Human Glial Tumors
Principal Investigator: Bob Carter, MD, PhD (MGH)
Co-Investigators: Fred Hochberg, MD (MGH); Xandra Breakefield, PhD (MGH)

Modeling Hepatitis C Virus Infection in Primary Human Hepatocytes Using Microscale Human Liver Tissue
Principal Investigator: Raymond Chung, MD (MGH)

Induced Pluripotent Stem Cell Lines from Patients with Primary Immunodeficiency
Principal Investigator: George Daley, MD, PhD (CHB)

Non-invasive Real-time Metabolic Imaging Using Hyperpolarized Pyruvate to Assess the Warburg Effect in Tumors
Co-Investigators: Pankaj Seth, PhD (BIDMC); Vikas Sukhatme, MD, PhD (BIDMC); David Alsop, PhD (BIDMC); Robert Lenkinski, PhD (BIDMC)

Targeted Approach to Treatment of Malignant Melanoma
Principal Investigator: Roya Khosravi-Far, PhD (BIDMC)
Co-Investigator: David Fisher, MD, PhD (MGH)

Is There a Cancer Developmental Signature in “Normal Tissue?”
Principal Investigator: Frank Kuo, MD, PhD (BWH)
Co-Investigator: Isaac Kohane, MD, PhD (CHB)

Polymer Bacterial Mimics as Cancer Vaccines
Co-Investigator: Glenn Dranoff, MD (DFCI)

Magnetic Resonance Imaging as a Genomic/Proteomic Expression Correlate to Characterize Renal Cell Carcinoma
Principal Investigator: Ivan Pedrosa, MD (BIDMC)
Co-Investigators: Sabina Signoretti, MD (DFCI); Rupal Bhatt, MD, PhD (BIDMC); Andrew Wagner, MD (BIDMC); David Alsop, PhD (BIDMC)

Development of an Iterative Platform that Accelerates the Discovery and Validation of Transcription Factor Inhibitors
Co-Investigator: Andrew Kung, MD, PhD (DFCI)

Adoptive Cell Therapy with Anti-tumor T Cells that are Resistant to Inhibition in the Tumor Microenvironment
Principal Investigator: Jerome Ritz, MD (DFCI)

M-array: A Novel Microarray Technique for Simultaneous Detection of Large and Small Mutations
Co-Investigator: James Gusella, MSc, PhD (MGH)

Download to view abstracts from all award recipients.