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Eleven new members join DF/HCC

Eleven individuals have recently joined DF/HCC. See below to learn more about these scientists and their research interests.

Umut Ozcan, MD (CHB)
Cancer Risk and Disparities

Research focus: The research focuses on the relation between Endoplasmic Reticulum (ER) stress and development of several different pathologies, such as insulin resistance, leptin resistance and cancer, in obesity. Specifically, the lab focuses on examining the crosstalk between unfolded protein response (UPR) and insulin receptor signaling systems; determining whether increased ER stress in obesity is associated with increased incidence of cancers in obesity; and investigating the role of ER stress in the development of obesity itself.

 

Dennis Wall, PhD (BIDMC)
Cancer Genetics, Cutaneous Oncology and Melanoma

Research focus: The lab focuses on the design and application of translational bioinformatics tools to help bring whole-genomic data to the point of clinical care, with current area of concentration in breast cancer, melanoma, lung and prostate cancer.

 

Anand Singh, MD (MGH)
Cancer Imaging, Sarcoma

Research focus: The research focuses on developing novel CT and MRI imaging-based computer-aided quantification techniques to provide objective viable tumor estimates. The studies involve integration of pathology slides and corresponding CT/MRI image viable tissue correlates.

Nada Kalaany, PhD (CHB)
Gastrointestinal Malignancies

Research focus: The labís goal is to identify the mechanisms underlying the association of obesity/Type 2 diabetes and cancer. The lab also seeks to understand how signaling pathways, such as PI3K/PTEN, influence tumor initiation and maintenance in the context of obesity and its metabolic syndrome and whether such an effect can be exploited therapeutically.

Joren Madsen, MD, PhD (MGH)
Cancer Immunology, Leukemia

Research focus: The lab is investigating ways to induce immune tolerance and allow allograft acceptance in patients in need of a transplant without the need for chronic immunosuppression. The goal of this inquiry is to achieve a state of tolerance to the donor organ which will also assure that immune competence is maintained so that the risk of cancer is similar to that of the general public.

Huihui Ye, MD (BIDMC)
Cancer Genetics, Prostate Cancer

Research focus: The research focuses on the molecular pathology of prostate cancer using a combined molecular and morphological approach. The primary goal is to investigate pathogenesis of aggressive prostate cancer and to discover molecular targets to facilitate its early detection.

David Ting, MD (MGH)
Cancer Genetics, Gastrointestinal Malignancies

Research focus: The research is focused on the role of non-coding RNA transcription in cancer as it relates to tumorigenesis and as novel biomarkers.

Ana Anderson, PhD (BWH)
Cancer Immunology

Research focus: The lab focuses on identifying the molecules and pathways that are involved in the mechanisms of immune suppression which would aid in the generation of therapies that restore anti-tumor immunity. Specifically the lab has been studying the molecule Tim-3 that is expressed on T cells and its ligand, galectin-9, and has found that these molecules play an important role in the promotion of myeloid-derived suppressor cells (MDSC), a population of myeloid cells that arises in tumor-bearing hosts and actively suppresses T cell responses.

 

Michael Kluk, MD, PhD (BWH)
Leukemia, Lymphoma and Myeloma

Research focus: The lab is  investigating the role of a novel immunohistochemical marker for certain types of lymphoma in human tissues.

Denise Faustman, MD, PhD (MGH)
Cancer Immunology

Research focus: The research program seeks to develop new, potentially curative, treatments for autoimmune diseases and to understand the regeneration of organs that occurs after autoimmunity is removed.

 

William Pu, MD (CHB)
Angiogenesis, Invasion and Metastasis

Research focus: The lab is studying the epigenetic and transcriptional regulation of angiogenesis in the cardiovascular system.