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Fourteen new members join DF/HCC

Fourteen individuals have recently joined DF/HCC. See below to learn more about these scientists and their research interests.

Job Dekker, PhD (University of Massachusetts Medical School)
Biostatistics and Computational Biology
Research focus: The lab focuses on the spatial organization of genomes and the roles of the three-dimensional arrangement of chromosomes in processes such as transcription regulation, chromosome segregation and genome stability, both in normal development and homeostasis and in human diseases such as cancer.

Dai Fukumura, MD, PhD (MGH)
Angiogenesis, Invasion and Metastasis, Gastrointestinal Malignancies
Research focus: The goal of the research is to uncover the fundamental nature of vascular biology in both physiological and pathophysiological settings, and to utilize this knowledge for the treatment of vascular disorders, metabolic and malignant diseases, and tissue engineering. To this end the lab has been developing and utilizing imaging techniques and animal models that have led to novel insights in angiogenesis, lymphangiogenesis, vascular function, microenvironment and treatment response.

Adam Kibel, MD (BWH)
Cancer Genetics, Prostate Cancer
Research focus: Research interest is centered on elucidating the molecular basis of prostate cancer aggressiveness by utilizing whole genome sequencing on aggressive and indolent prostate tumors, to determine if there are driver mutations for aggressive disease, as well as whole exome sequencing on germline DNA to determine if rare variants are associated with risk of aggressive disease.

Maria Kontaridis, PhD (BIDMC)
Cancer Genetics, Translational Pharmacology and Early Therapeutic Trials
Research focus: The research program focuses on the fundamental mechanisms underlying RASopathy disorders, and, in particular, the mechanisms by which mutations in protein tyrosine phosphatases (PTPs) lead to abnormal development, aberrant molecular signaling, and disease onset.

Vijay Kuchroo, DVM, PhD (BWH)
Cancer Immunology
Research focus: The lab has a strong background in immune regulation and autoimmunity, particularly in the induction and regulation of EAE. The research group first identified Tim-3 as a molecule differentially expressed on Th1 cells. Since the initial observation, research has shown that Tim-3 is an inhibitory molecule that induces cell death/exhaustion in effector T cells and, therefore, plays an important role in chronic viral diseases (HIV, HCV), cancers and autoimmune diseases.

Stacey Missmer, ScD (BWH)
Cancer Epidemiology, Gynecologic Cancers
Research focus: Much of the research has focused on collection and maintenance of a large biorepository (NHS), as well as evaluation of between and within person variation of biomarkers and their implication on associative interpretation.

Arthur Moser, MD, FACS (BIDMC)
Cancer Immunology, Gastrointestinal Malignancies
Research focus: The labís translational pancreatic cancer research focuses on validating predictive models both to specify the risk of surgery as well as to predict a patientís likely survival after surgery.

Rosalynn Nazarian, MD (MGH)
Cutaneous Oncology and Melanoma
Research focus: Research efforts focus on elucidating the pathophysiologic basis for cutaneous fibrosing disorders and immunohistochemical investigations in cutaneous neoplasms including melanoma.

Mark Puder, MD, PhD (BCH)
Angiogenesis, Invasion and Metastasis, Cutaneous Oncology and Melanoma
Research focus: The lab has been investigating the mechanisms of liver injury and regeneration as a model of treatment of parenteral nutrition associated liver injury and as a model of rapid tumor growth, with a particular emphasis on the role of bioactive lipids and their role in organ and tumor growth.

Lisa Signorello, ScD (HSPH)
Cancer Epidemiology, Cancer Risk and Disparities
Research focus: Major research interest is cancer disparities, working in the context of population-based epidemiologic studies, with a strong focus on the role of inherited susceptibility that may underlie the excess burden of prostate cancer among African American men.

Manisha Thakuria, MD (BWH)
Cutaneous Oncology and Melanoma
Research focus: The lab promotes active research into mechanisms of disease, novel therapies, and outcomes of treatment for Merkel cell carcinoma in an effort to help to define the optimal management of this type of cancer.

Alexandros Tzatsos, MD, PhD (MGH)
Cancer Genetics, Gastrointestinal Malignancies
Research focus: Research objectives aim to define how changes in the epigenetic landscape influence the initiation and maintenance of human cancers and to identify the biochemical mediators involved in these processes.

Tyler VanderWeele, PhD (HSPH)
Biostatistics and Computational Biology, Cancer Epidemiology
Research focus: The focus of the research is on epidemiologic methods and how to distinguish between association and causation in observational research, with application to the study of the role of religion and spirituality in end-of-life cancer care, and to examining the mechanisms governing associations between genetic and environmental risk factors and cancer risk.

Xuehong Zhang, ScD (BWH)
Breast Cancer, Gastrointestinal Malignancies
Research focus: Primary research focuses on cancer epidemiology and nutritional epidemiology. The lab investigates the potential mechanisms through which lifestyle, dietary, and biomedical determinants may affect cancer risk in order to develop evidence-based cancer prevention strategies, especially those of the breast and colorectum.