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Loren D. Walensky, MD, PhD


  • Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA.The retinoblastoma protein induces apoptosis directly at the mitochondria.Genes Dev. 2013 May 1;27(9):1003-15.
  • Walensky LD.Playing FullBAK.Cell Cycle. 2013 Apr 11;12(9).
  • Leshchiner ES, Braun CR, Bird GH, Walensky LD.Direct activation of full-length proapoptotic BAK.Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E986-95.
  • Walensky LD.Protein-protein interactions: A PUMA mechanism unfolds.Nat Chem Biol. 2013 Mar;9(3):141-3.
  • Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD.A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.Chem Biol. 2012 Sep 21;19(9):1175-86.
  • Walensky LD.Interview with Loren D Walensky.Future Med Chem. 2012 Aug;4(12):1537-9.
  • Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD.Direct and selective small-molecule activation of proapoptotic BAX.Nat Chem Biol. 2012 Jul;8(7):639-45.
  • Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR.Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling.Sci Transl Med. 2012 Aug 22;4(148):148ra117.
  • Walensky LD.Stemming danger with Golgified BAX.Mol Cell. 2012 Jun 8;46(5):554-6.
  • LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD.A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.J Clin Invest. 2012 Jun 1;122(6):2018-31.
  • Gavathiotis E, Walensky LD.Tracking BAX once its trigger is pulled.Cell Cycle. 2011 Mar 15;10(6).
  • Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD.Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.Chem Biol. 2010 Dec 22;17(12):1325-33.
  • Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD.A stapled p53 helix overcomes HDMX-mediated suppression of p53.Cancer Cell. 2010 Nov 16;18(5):411-22.
  • Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD.BH3-triggered structural reorganization drives the activation of proapoptotic BAX.Mol Cell. 2010 Nov 12;40(3):481-92.
  • Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD.Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14093-8.
  • Stewart ML, Fire E, Keating AE, Walensky LD.The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.Nat Chem Biol. 2010 Aug;6(8):595-601.
  • Gavathiotis E,Suzuki M,Davis ML,Pitter K,Bird GH,Katz SG,Tu HC,Kim H,Cheng EH,Tjandra N,Walensky LD.BAX activation is initiated at a novel interaction site.Nature. 2008 Oct 23;455(7216):1076-81.
  • Bird GH,Bernal F,Pitter K,Walensky LD.Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains.Methods Enzymol. 2008;446:369-86.
  • Pitter K,Bernal F,Labelle J,Walensky LD.Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains.Methods Enzymol. 2008;446:387-408.
  • Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.Dual role of proapoptotic BAD in insulin secretion and beta cell survival.Nat Med. 2008 Feb;14(2):144-53.
  • Verdine GL, Walensky LD.The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members.Clin Cancer Res. 2007 Dec 15;13(24):7264-70. Review.
  • Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL.Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide [J. Am. Chem. Soc. 2007, 129, 2456-2457].J Am Chem Soc. 2007 Apr 25;129(16):5298.
  • Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ.A membrane-targeted BID BH3 peptide is sufficient for high potency activation of BAX in vitro.J Biol Chem. 2006 Dec 1;281(48):36999-7008.
  • Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ.A stapled BID BH3 helix directly binds and activates BAX.Mol Cell. 2006 Oct 20;24(2):199-210.
  • Walensky LD.BCL-2 in the crosshairs: tipping the balance of life and death.Cell Death Differ. 2006 Aug;13(8):1339-50. Review.
  • Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ.Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.Science. 2004 Sep 3;305(5689):1466-70.
  • Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ.Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.Cancer Cell. 2002 Sep;2(3):183-92.