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Rohit Kulkarni, MD, PhD

Publications

  • Teo AK, Wagers AJ, Kulkarni RN.New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism.Cell Metab. 2013 Dec 3;18(6):775-91.
    24035588
  • Su D, Shukla AK, Chen B, Kim JS, Nakayasu E, Qu Y, Aryal U, Weitz K, Clauss TR, Monroe ME, Camp DG, Bigelow DJ, Smith RD, Kulkarni RN, Qian WJ.Quantitative site-specific reactivity profiling of S-nitrosylation in mouse skeletal muscle using cysteinyl peptide enrichment coupled with mass spectrometry.Free Radic Biol Med. 2013 Apr;57:68-78.
    23277143
  • Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R.Near-infrared fluorescent probe for imaging of pancreatic Beta cells.Bioconjug Chem. 2010 Jul 21;21(7):1362-8.
    20583828
  • Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE.Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.J Clin Invest. 2010 Jun 1;120(6):2171-83.
    20440072
  • Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC.High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and {beta}-cell apoptosis.FASEB J. 2010 May;24(5):1497-505.
    20032314
  • Cornu M, Modi H, Kawamori D, Kulkarni RN, Joffraud M, Thorens B.Glucagon-like peptide-1 (GLP-1) increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor (IGF-1R) expression.J Biol Chem. 2010 Apr 2;285(14):10538-45.
    20145256
  • Kawamori D, Welters HJ, Kulkarni RN.Molecular Pathways Underlying the Pathogenesis of Pancreatic alpha-Cell Dysfunction.Adv Exp Med Biol. 2010;654:421-45. Review.
    20217508
  • Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN.Insulin signaling regulates mitochondrial function in pancreatic beta-cells.PLoS ONE. 2009;4(11):e7983.
    19956695
  • Zhou JY, Petritis BO, Petritis K, Norbeck AD, Weitz KK, Moore RJ, Camp DG, Kulkarni RN, Smith RD, Qian WJ.Mouse-specific tandem IgY7-SuperMix immunoaffinity separations for improved LC-MS/MS coverage of the plasma proteome.J Proteome Res. 2009 Nov;8(11):5387-95.
    19722698
  • Heinrichs S, Kulkarni RV, Bueso-Ramos CE, Levine RL, Loh ML, Li C, Neuberg D, Kornblau SM, Issa JP, Gilliland DG, Garcia-Manero G, Kantarjian HM, Estey EH, Look AT.Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.Leukemia. 2009 Sep;23(9):1605-13.
    19387468
  • Assmann A,Ueki K,Winnay JN,Kadowaki T,Kulkarni RN.Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.Mol Cell Biol. 2009 Jun;29(11):3219-28.
    19273608
  • Welters HJ,Kulkarni RN.Wnt signaling: relevance to beta-cell biology and diabetes.Trends Endocrinol Metab. 2008 Dec;19(10):349-55. Review.
    18926717
  • Tseng YH,Kokkotou E,Schulz TJ,Huang TL,Winnay JN,Taniguchi CM,Tran TT,Suzuki R,Espinoza DO,Yamamoto Y,Ahrens MJ,Dudley AT,Norris AW,Kulkarni RN,Kahn CR.New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.Nature. 2008 Aug 21;454(7207):1000-4.
    18719589
  • Petyuk VA,Qian WJ,Hinault C,Gritsenko MA,Singhal M,Monroe ME,Camp DG 2nd,Kulkarni RN,Smith RD.Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues.J Proteome Res. 2008 Aug;7(8):3114-26.
    18570455
  • DeAngelis AM,Heinrich G,Dai T,Bowman TA,Patel PR,Lee SJ,Hong EG,Jung DY,Assmann A,Kulkarni RN,Kim JK,Najjar SM.Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism.Diabetes. 2008 Sep;57(9):2296-303.
    18544705
  • Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.J Clin Invest. 2007 Nov;117(11):3463-74.
    17932564
  • Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN.Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.J Clin Invest. 2007 Oct;117(10):2860-8.
    17909627
  • Matsumura K, Chang BH, Fujimya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L.Aquaporin 7 is a {beta} Cell Protein and Regulator of Intra-islet Glycerol Content and Glycerol Kinase Activity, {beta} Cell Mass, and Insulin Production and Secretion.Mol Cell Biol. 2007 Sep;27(17):6026-37.
    17576812
  • Kulkarni RN, Kahn CR.Ephs and ephrins keep pancreatic Beta cells connected.Cell. 2007 Apr 20;129(2):241-3.
    17448984
  • Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN.Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.Proc Natl Acad Sci U S A. 2007 May 22;104(21):8977-82.
    17416680
  • Pissios P, Ozcan U, Kokkotou E, Okada T, Liew CW, Liu S, Peters JN, Dahlgren G, Karamchandani J, Kudva YC, Kurpad AJ, Kennedy RT, Maratos-Flier E, Kulkarni RN.Melanin concentrating hormone is a novel regulator of islet function and growth.Diabetes. 2007 Feb;56(2):311-9.
    17259374
  • Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ.Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.Mol Cell Biol. 2006 Nov;26(22):8217-27.
    16966378
  • Neubauer N, Kulkarni RN.Molecular approaches to study control of glucose homeostasis.ILAR J. 2006;47(3):199-211. Review.
    16804195
  • Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M.TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.Science. 2006 Jun 23;312(5781):1763-6.
    16794074
  • Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, Kulkarni RN.Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.Nat Genet. 2006 May;38(5):583-8.
    16642022
  • He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL.Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):787-93.
    16469952
  • Kulkarni RN.New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass.Rev Endocr Metab Disord. 2005 Aug;6(3):199-210.
    16151624
  • Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR.Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.Cell. 2005 Aug 12;122(3):337-49.
    16096055
  • Bates SH, Kulkarni RN, Seifert M, Myers MG.Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis.Cell Metab. 2005 Mar;1(3):169-78.
    16054060
  • Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN.Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E337-46.
    15827066
  • Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR.PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.J Clin Invest. 2004 Sep;114(6):828-36.
    15372107
  • Kulkarni RN, Roper MG, Dahlgren G, Shih DQ, Kauri LM, Peters JL, Stoffel M, Kennedy RT.Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.Diabetes. 2004 Jun;53(6):1517-25.
    15161756
  • Kulkarni RN, Kahn CR.Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes.Science. 2004 Feb 27;303(5662):1311-2.
    14988544
  • Kulkarni RN.The islet beta-cell.Int J Biochem Cell Biol. 2004 Mar;36(3):365-71.
    14687913
  • Du K, Herzig S, Kulkarni RN, Montminy M.TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.Science. 2003 Jun 6;300(5625):1574-7.
    12791994
  • Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR.Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.Diabetes. 2003 Jun;52(6):1528-34.
    12765966
  • Kulkarni RN, Okada T.Tissue-specific targeting of the insulin receptor gene.Endocrine. 2002 Dec;19(3):257-66.
    12624425
  • Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR.beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.Nat Genet. 2002 May;31(1):111-5.
    11923875
  • Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR.Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.J Clin Invest. 1999 Dec;104(12):R69-75.
    10606633
  • Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR.Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.Cell. 1999 Feb 5;96(3):329-39.
    10025399
  • Kulkarni RN, Wang ZL, Wang RM, Hurley JD, Smith DM, Ghatei MA, Withers DJ, Gardiner JV, Bailey CJ, Bloom SR.Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.J Clin Invest. 1997 Dec 1;100(11):2729-36.
    9389736