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Michael C. Carroll, PhD


  • Dwyer DF, Woodruff MC, Carroll MC, Austen KF, Gurish MF.B Cells Regulate CD4+ T Cell Responses to Papain following B Cell Receptor-Independent Papain Uptake.J Immunol. 2014 Jun 13.
  • Woodruff MC, Herndon CN, Heesters BA, Carroll MC.Contextual analysis of immunological response through whole-organ fluorescent imaging.Lymphat Res Biol. 2013 Sep;11(3):121-7.
  • Chatterjee P, Agyemang AF, Alimzhanov MB, Degn S, Tsiftsoglou SA, Alicot E, Jones SA, Ma M, Carroll MC.Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.Eur J Immunol. 2013 Sep;43(9):2441-50.
  • Heesters BA, Chatterjee P, Kim YA, Gonzalez SF, Kuligowski MP, Kirchhausen T, Carroll MC.Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation.Immunity. 2013 Jun 27;38(6):1164-75.
  • Carroll MC, Isenman DE.Regulation of humoral immunity by complement.Immunity. 2012 Aug 24;37(2):199-207.
  • Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ.Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.Immunity. 2012 Aug 24;37(2):276-89.
  • Detre C, Keszei M, Garrido-Mesa N, Kis-Toth K, Castro W, Agyemang AF, Veerapen N, Besra GS, Carroll MC, Tsokos GC, Wang N, Leadbetter EA, Terhorst C.SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.Blood. 2012 Jul 5;120(1):122-9.
  • Gonzalez SF, Degn SE, Pitcher LA, Woodruff M, Heesters BA, Carroll MC.Trafficking of B cell antigen in lymph nodes.Annu Rev Immunol. 2011 Apr 23;29:215-33.
  • McCloskey ML, Curotto de Lafaille MA, Carroll MC, Erlebacher A.Acquisition and presentation of follicular dendritic cell-bound antigen by lymph node-resident dendritic cells.J Exp Med. 2011 Jan 17;208(1):135-48.
  • Gonzalez SF, Kuligowski MP, Pitcher LA, Roozendaal R, Carroll MC.The role of innate immunity in B cell acquisition of antigen within LNs.Adv Immunol. 2010;106:1-19.
  • Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, Pitcher LA, Degn SE, Turley SJ, Carroll MC.Complement-dependent transport of antigen into B cell follicles.J Immunol. 2010 Sep 1;185(5):2659-64. Review.
  • Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, Pitcher LA, Degn SE, Kim YA, Cloninger MJ, Martinez-Pomares L, Gordon S, Turley SJ, Carroll MC.Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.Nat Immunol. 2010 May;11(5):427-34.
  • Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC.Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20960-5.
  • Barrington RA, Schneider TJ, Pitcher LA, Mempel TR, Ma M, Barteneva NS, Carroll MC.Uncoupling CD21 and CD19 of the B-cell coreceptor.Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14490-5.
  • Gonzalez SF, Pitcher LA, Mempel T, Schuerpf F, Carroll MC.B cell acquisition of antigen in vivo.Curr Opin Immunol. 2009 Jun;21(3):251-7. Review.
  • Roozendaal R,Mempel TR,Pitcher LA,Gonzalez SF,Verschoor A,Mebius RE,von Andrian UH,Carroll MC.Conduits mediate transport of low-molecular-weight antigen to lymph node follicles.Immunity. 2009 Feb;30(2):264-76.
  • Chiu IM,Chen A,Zheng Y,Kosaras B,Tsiftsoglou SA,Vartanian TK,Brown RH Jr,Carroll MC.T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17913-8.
  • Zhang M,Alicot EM,Carroll MC.Human natural IgM can induce ischemia/reperfusion injury in a murine intestinal model.Mol Immunol. 2008 Sep;45(15):4036-9.
  • Maier M,Peng Y,Jiang L,Seabrook TJ,Carroll MC,Lemere CA.Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.J Neurosci. 2008 Jun 18;28(25):6333-41.
  • You Z, Yang J, Takahashi K, Yager PH, Kim HH, Qin T, Stahl GL, Ezekowitz RA, Carroll MC, Whalen MJ.Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4.J Cereb Blood Flow Metab. 2007 Dec;27(12):1954-64.
  • Suber F, Carroll MC, Moore FD.Innate response to self-antigen significantly exacerbates burn wound depth.Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3973-7.
  • Paul E, Nelde A, Verschoor A, Carroll MC.Follicular exclusion of autoreactive B cells requires FcgammaRIIb.Int Immunol. 2007 Apr;19(4):365-73.
  • Jayasekera JP, Moseman EA, Carroll MC.Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity.J Virol. 2007 Apr;81(7):3487-94.
  • Chan RK, Ibrahim SI, Takahashi K, Kwon E, McCormack M, Ezekowitz A, Carroll MC, Moore FD, Austen WG.The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusion.J Immunol. 2006 Dec 1;177(11):8080-5.
  • Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS.Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.Cancer Cell. 2006 Nov;10(5):401-11.
  • Shimizu I, Kawahara T, Haspot F, Bardwell PD, Carroll MC, Sykes M.B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells.Blood. 2007 Feb 15;109(4):1773-81.
  • Zhang M, Takahashi K, Alicot EM, Vorup-Jensen T, Kessler B, Thiel S, Jensenius JC, Ezekowitz RA, Moore FD, Carroll MC.Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury.J Immunol. 2006 Oct 1;177(7):4727-34.
  • Zhang M, Carroll MC.Natural antibody mediated innate autoimmune response.Mol Immunol. 2007 Jan;44(1-3):103-10. Review.
  • Barrington RA, Borde M, Rao A, Carroll MC.Involvement of NFAT1 in B Cell Self-Tolerance.J Immunol. 2006 Aug 1;177(3):1510-5.
  • Banda NK, Thurman JM, Kraus D, Wood A, Carroll MC, Arend WP, Holers VM.Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis.J Immunol. 2006 Aug 1;177(3):1904-12.
  • Brockman MA, Verschoor A, Zhu J, Carroll MC, Knipe DM.Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells.J Virol. 2006 Jul;80(14):7111-7.
  • Morra M, Barrington RA, Abadia-Molina AC, Okamoto S, Julien A, Gullo C, Kalsy A, Edwards MJ, Chen G, Spolski R, Leonard WJ, Huber BT, Borrow P, Biron CA, Satoskar AR, Carroll MC, Terhorst C.Defective B cell responses in the absence of SH2D1A.Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4819-23.
  • Mao C, Jiang L, Melo-Jorge M, Puthenveetil M, Zhang X, Carroll MC, Imanishi-Kari T.T cell-independent somatic hypermutation in murine B cells with an immature phenotype.Immunity. 2004 Feb;20(2):133-44.
  • Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K.B cell receptor signal strength determines B cell fate.Nat Immunol. 2004 Mar;5(3):317-27.
  • Buono C, Come CE, Witztum JL, Maguire GF, Connelly PW, Carroll M, Lichtman AH.Influence of C3 deficiency on atherosclerosis.Circulation. 2002 Jun 25;105(25):3025-31.
  • Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D.Arthritis critically dependent on innate immune system players.Immunity. 2002 Feb;16(2):157-68.
  • Tomasson MH, Sternberg DW, Williams IR, Carroll M, Cain D, Aster JC, Ilaria RL, Van Etten RA, Gilliland DG.Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581.J Clin Invest. 2000 Feb;105(4):423-32.
  • Carroll MC.The role of complement in B cell activation and tolerance.Adv Immunol. 2000;74:61-88.
  • Boes M, Prodeus AP, Schmidt T, Carroll MC, Chen J.A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection.J Exp Med. 1998 Dec 21;188(12):2381-6.
  • Prodeus AP, Goerg S, Shen LM, Pozdnyakova OO, Chu L, Alicot EM, Goodnow CC, Carroll MC.A critical role for complement in maintenance of self-tolerance.Immunity. 1998 Nov;9(5):721-31.
  • Qin D, Wu J, Carroll MC, Burton GF, Szakal AK, Tew JG.Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses.J Immunol. 1998 Nov 1;161(9):4549-54.
  • Carroll MC.The role of complement and complement receptors in induction and regulation of immunity.Annu Rev Immunol. 1998;16:545-68.
  • Boes M, Esau C, Fischer MB, Schmidt T, Carroll M, Chen J.Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM.J Immunol. 1998 May 15;160(10):4776-87.
  • Hammerberg C, Katiyar SK, Carroll MC, Cooper KD.Activated complement component 3 (C3) is required for ultraviolet induction of immunosuppression and antigenic tolerance.J Exp Med. 1998 Apr 6;187(7):1133-8.
  • Fischer MB, Goerg S, Shen L, Prodeus AP, Goodnow CC, Kelsoe G, Carroll MC.Dependence of germinal center B cells on expression of CD21/CD35 for survival.Science. 1998 Apr 24;280(5363):582-5.
  • Carroll MC, Prodeus AP.Linkages of innate and adaptive immunity.Curr Opin Immunol. 1998 Feb;10(1):36-40.
  • Fischer MB, Ma M, Hsu NC, Carroll MC.Local synthesis of C3 within the splenic lymphoid compartment can reconstitute the impaired immune response in C3-deficient mice.J Immunol. 1998 Mar 15;160(6):2619-25.
  • Quigg RJ, Lim A, Haas M, Alexander JJ, He C, Carroll MC.Immune complex glomerulonephritis in C4- and C3-deficient mice.Kidney Int. 1998 Feb;53(2):320-30.
  • Tang T, Rosenkranz A, Assmann KJ, Goodman MJ, Gutierrez-Ramos JC, Carroll MC, Cotran RS, Mayadas TN.A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis.J Exp Med. 1997 Dec 1;186(11):1853-63.
  • Sheerin NS, Springall T, Carroll MC, Hartley B, Sacks SH.Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice.Clin Exp Immunol. 1997 Dec;110(3):403-9.
  • Prodeus AP, Zhou X, Maurer M, Galli SJ, Carroll MC.Impaired mast cell-dependent natural immunity in complement C3-deficient mice.Nature. 1997 Nov 13;390(6656):172-5.
  • Sultan AA, Briones MR, Gerwin N, Carroll MC, Nussenzweig V.Sporozoites of Plasmodium yoelii infect mice with targeted deletions in ICAM-1 and ICAM-2 or complement components C3 and C4.Mol Biochem Parasitol. 1997 Sep;88(1-2):263-6.
  • Schorey JS, Carroll MC, Brown EJ.A macrophage invasion mechanism of pathogenic mycobacteria.Science. 1997 Aug 22;277(5329):1091-3.
  • Fischer MB, Prodeus AP, Nicholson-Weller A, Ma M, Murrow J, Reid RR, Warren HB, Lage AL, Moore FD, Rosen FS, Carroll MC.Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement.J Immunol. 1997 Jul 15;159(2):976-82.
  • Reid RR, Prodeus AP, Khan W, Hsu T, Rosen FS, Carroll MC.Endotoxin shock in antibody-deficient mice: unraveling the role of natural antibody and complement in the clearance of lipopolysaccharide.J Immunol. 1997 Jul 15;159(2):970-5.
  • Carroll MC, Fischer MB.Complement and the immune response.Curr Opin Immunol. 1997 Feb;9(1):64-9.