Bruce Demple, PhD

Publications

• Fung H, Demple B.Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.J Biol Chem. 2011 Feb 18;286(7):4968-77.
  21081487
• Liu P, Demple B.DNA repair in mammalian mitochondria: Much more than we thought?.Environ Mol Mutagen. 2010 Jun;51(5):417-26. Review.
  20544882
• Auerbach PA, Demple B.Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae.Mutagenesis. 2010 Jan;25(1):63-9.
  19901007
• Lee PE, Demple B, Barton JK.DNA-mediated redox signaling for transcriptional activation of SoxR.Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13164-8.
  19651620
• Kuwano Y,Rabinovic A,Srikantan S,Gorospe M,Demple B.Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation.Mol Cell Biol. 2009 May;29(10):2622-35.
  19289500
• Zheng L,Zhou M,Guo Z,Lu H,Qian L,Dai H,Qiu J,Yakubovskaya E,Bogenhagen DF,Demple B,Shen B.Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.Mol Cell. 2008 Nov 7;32(3):325-36.
  18995831
• Liu P,Qian L,Sung JS,de Souza-Pinto NC,Zheng L,Bogenhagen DF,Bohr VA,Wilson DM 3rd,Shen B,Demple B.Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.Mol Cell Biol. 2008 Aug;28(16):4975-87.
  18541666
• Gorodetsky AA, Dietrich LE, Lee PE, Demple B, Newman DK, Barton JK.DNA binding shifts the redox potential of the transcription factor SoxR.Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3684-9.
  18316718
• Leautaud V, Demple B.Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitrosative or alkylation stress.BMC Mol Biol. 2007 Dec 20;8(1):116.
  18096048
• Gellon L, Carson DR, Carson JP, Demple B.Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair.DNA Repair (Amst). 2008 Feb 1;7(2):187-98.
  17983848
• Narciso L, Fortini P, Pajalunga D, Franchitto A, Liu P, Degan P, Frechet M, Demple B, Crescenzi M, Dogliotti E.Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury.Proc Natl Acad Sci U S A. 2
  17940040
• Fung H, Liu P, Demple B.ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.Mol Cell Biol. 2007 Dec;27(24):8834-47.
  17938202
• Reiter TA, Pang B, Dedon P, Demple B.Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation.J Biol Chem. 2006 Dec 1;281(48):36603-12.
  17020887
• Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J.The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.Mol Cell. 2006 Jul 7;23(1):133-42.
  16818237
• Sung JS, Demple B.Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links.Methods Enzymol. 2006;408:48-64.
  16793362
• Sung JS, Demple B.Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA.FEBS J. 2006 Apr;273(8):1620-9. Review.
  16623699
• Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger M
  16439206
• Park W, Peña-Llopis S, Lee Y, Demple B.Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coli.Biochem Biophys Res Commun. 2006 Mar 3;341(1):51-6.
  16412384
• Lee Y, Peña-Llopis S, Kang YS, Shin HD, Demple B, Madsen EL, Jeon CO, Park W.Expression analysis of the fpr (ferredoxin-NADP+ reductase) gene in Pseudomonas putida KT2440.Biochem Biophys Res Commun. 2006 Jan 27;339(4):1246-54.
  16360643
• Auerbach P, Bennett RA, Bailey EA, Krokan HE, Demple B.Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17711-6.
  16314579
• Demple B, Sung JS.Molecular and biological roles of Ape1 protein in mammalian base excision repair.DNA Repair (Amst). 2005 Dec 8;4(12):1442-9. Review.
  16199212
• Sung JS, Demott MS, Demple B.Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta.J Biol Chem. 2005 Nov 25;280(47):39095-103.
  16188889
• Reiter TA, Demple B.Carbon monoxide mediates protection against nitric oxide toxicity in HeLa cells.Free Radic Biol Med. 2005 Oct 15;39(8):1075-88.
  16198234
• McLaughlin LM, Demple B.Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53.Cancer Res. 2005 Jul 15;65(14):6097-104.
  16024610
• Koutsolioutsou A, Peña-Llopis S, Demple B.Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates.Antimicrob Agents Chemother. 2005 Jul;49(7):2746-52.
  15980345
• Fung H, Demple B.A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells.Mol Cell. 2005 Feb 4;17(3):463-70.
  15694346
• Bishop A, Yet SF, Lee ME, Perrella MA, Demple B.A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia.Biochem Biophys Res Commun. 2004 Dec 3;325(1):3-9.
  15522193
• Chander M, Demple B.Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.J Biol Chem. 2004 Oct 1;279(40):41603-10.
  15292172
• Demple B.Protection from the dark side of NO: signaling and cellular defenses against nitric oxide toxicity.IUBMB Life. 2004 Feb;56(2):59-64.
  15085929
• Wong D, Demple B.Modulation of the 5'-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1.J Biol Chem. 2004 Jun 11;279(24):25268-75.
  15078879
• Pomposiello PJ, Koutsolioutsou A, Carrasco D, Demple B.SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli.J Bacteriol. 2003 Nov;185(22):6624-32.
  14594836
• Wong D, DeMott MS, Demple B.Modulation of the 3'-->5'-exonuclease activity of human apurinic endonuclease (Ape1) by its 5'-incised Abasic DNA product.J Biol Chem. 2003 Sep 19;278(38):36242-9.
  12857737
• Chander M, Raducha-Grace L, Demple B.Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.J Bacteriol. 2003 Apr;185(8):2441-50.
  12670967
• Xu YJ, DeMott MS, Hwang JT, Greenberg MM, Demple B.Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA.DNA Repair (Amst). 2003 Feb 3;2(2):175-85.
  12531388
• Demple B, DeMott MS.Dynamics and diversions in base excision DNA repair of oxidized abasic lesions.Oncogene. 2002 Dec 16;21(58):8926-34.
  12483509
• Demple B.Signal transduction by nitric oxide in cellular stress responses.Mol Cell Biochem. 2002 May-Jun;234-235(1-2):11-8.
  12162422
• DeMott MS, Beyret E, Wong D, Bales BC, Hwang JT, Greenberg MM, Demple B.Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone.J Biol Chem. 2002 Mar 8;277(10):7637-40.
  11805079
• Yang H, Clendenin WM, Wong D, Demple B, Slupska MM, Chiang JH, Miller JH.Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch.Nucleic Acids Res. 2001 Feb 1;29
  11160897
• Ding H, Demple B.Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator.Proc Natl Acad Sci U S A. 2000 May 9;97(10):5146-50.
  10805777
• Kwon HJ, Bennik MH, Demple B, Ellenberger T.Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA.Nat Struct Biol. 2000 May;7(5):424-30.
  10802742
• Bishop A, Marquis JC, Cashman NR, Demple B.Adaptive resistance to nitric oxide in motor neurons.Free Radic Biol Med. 1999 Apr;26(7-8):978-86.
  10232842
• Ding H, Demple B.Thiol-mediated disassembly and reassembly of [2Fe-2S] clusters in the redox-regulated transcription factor SoxR.Biochemistry. 1998 Dec 8;37(49):17280-6.
  9860842
• Xu YJ, Kim EY, Demple B.Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase beta.J Biol Chem. 1998 Oct 30;273(44):28837-44.
  9786884
• Marquis JC, Demple B.Complex genetic response of human cells to sublethal levels of pure nitric oxide.Cancer Res. 1998 Aug 1;58(15):3435-40.
  9699677
• Harrison L, Ascione AG, Takiguchi Y, Wilson DM, Chen DJ, Demple B.Comparison of the promoters of the mouse (APEX) and human (APE) apurinic endonuclease genes.Mutat Res. 1997 Dec;385(3):159-72.
  9506886
• White DG, Goldman JD, Demple B, Levy SB.Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli.J Bacteriol. 1997 Oct;179(19):6122-6.
  9324261
• González-Flecha B, Demple B.Transcriptional regulation of the Escherichia coli oxyR gene as a function of cell growth.J Bacteriol. 1997 Oct;179(19):6181-6.
  9324269
• Ding H, Demple B.In vivo kinetics of a redox-regulated transcriptional switch.Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8445-9.
  9237996
• Bennett RA, Wilson DM, Wong D, Demple B.Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7166-9.
  9207062
• Hidalgo E, Demple B.Spacing of promoter elements regulates the basal expression of the soxS gene and converts SoxR from a transcriptional activator into a repressor.EMBO J. 1997 Mar 3;16(5):1056-65.
  9118944
• Wilson DM, Takeshita M, Demple B.Abasic site binding by the human apurinic endonuclease, Ape, and determination of the DNA contact sites.Nucleic Acids Res. 1997 Mar 1;25(5):933-9.
  9023101
• Hidalgo E, Ding H, Demple B.Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form.Cell. 1997 Jan 10;88(1):121-9.
  9019397