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Bruce R. Rosen, MD, PhD


  • Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER.Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation.Oncologist. 2014 Jan;19(1):75-81.
  • Catalano OA, Rosen BR, Sahani DV, Hahn PF, Guimaraes AR, Vangel MG, Nicolai E, Soricelli A, Salvatore M.Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients--a hypothesis-generating exploratory study.Radiology. 2013 Dec;269(3):857-69.
  • Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK.Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19059-64.
  • Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG.Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.Nat Med. 2013 Sep;19(9):1178-83.
  • Andronesi OC, Rapalino O, Gerstner E, Chi A, Batchelor TT, Cahill DP, Sorensen AG, Rosen BR.Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.J Clin Invest. 2013 Sep 3;123(9):3659-63. Review.
  • Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG.Sensitivity of MRI Tumor Biomarkers to VEGFR Inhibitor Therapy in an Orthotopic Mouse Glioma Model.PLoS ONE. 2011;6(3):e17228.
  • Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EM, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJ, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A.Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal.Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15246-51.
  • Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG.In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.Neuro Oncology. 2010 Apr;12(4):341-50.
  • Liu CH, Ren JQ, Yang J, Liu CM, Mandeville JB, Rosen BR, Bhide PG, Yanagawa Y, Liu PK.DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains.J Neurosci. 2009 Aug 26;29(34):10663-70.
  • Blackwell ML,Farrar CT,Fischl B,Rosen BR.Target-specific contrast agents for magnetic resonance microscopy.Neuroimage. 2009 Jun;46(2):382-93.
  • Liu CH,You Z,Liu CM,Kim YR,Whalen MJ,Rosen BR,Liu PK.Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains.J Neurosci. 2009 Mar 18;29(11):3508-17.
  • Huang S,Liu C,Dai G,Kim YR,Rosen BR.Manipulation of tissue contrast using contrast agents for enhanced MR microscopy in ex vivo mouse brain.Neuroimage. 2009 Jul 1;46(3):589-99.
  • Devor A,Hillman EM,Tian P,Waeber C,Teng IC,Ruvinskaya L,Shalinsky MH,Zhu H,Haslinger RH,Narayanan SN,Ulbert I,Dunn AK,Lo EH,Rosen BR,Dale AM,Kleinfeld D,Boas DA.Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex.J Neurosci. 2008 Dec 31;28(53):14347-57.
  • Witzel T,Lin FH,Rosen BR,Wald LL.Stimulus-induced Rotary Saturation (SIRS): a potential method for the detection of neuronal currents with MRI.Neuroimage. 2008 Oct 1;42(4):1357-65.
  • Huang S, Vader D, Wang Z, Stemmer-Rachamimov A, Weitz DA, Dai G, Rosen BR, Deisboeck TS.Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study.BMC Med Imaging. 2008;8:3.
  • Farrar CT,Dai G,Novikov M,Rosenzweig A,Weissleder R,Rosen BR,Sosnovik DE.Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging.NMR Biomed. 2008 Jun;21(5):453-63.
  • Liu CH, Kim YR, Ren JQ, Eichler F, Rosen BR, Liu PK.Imaging cerebral gene transcripts in live animals.J Neurosci. 2007 Jan 17;27(3):713-22.
  • Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM.Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models.J Cereb Blood Flow Metab. 2007 Jan;27(1):196-204.
  • Kim YR, van Meer MP, Mandeville JB, Tejima E, Dai G, Topalkara K, Qui J, Dijkhuizen RM, Moskowitz MA, Lo EH, Rosen BR.fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains.J Cereb Blood Flow Metab. 2007 Jan;27(1):142-53.
  • Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH.Role of matrix metalloproteinases in delayed cortical responses after stroke.Nat Med. 2006 Apr;12(4):441-5.
  • Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hamalainen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA, Dale AM, Rosen BR, Stufflebeam SM.The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients.Epilepsy Res. 2006 Apr;69(1):80-6.
  • Bar M, Kassam KS, Ghuman AS, Boshyan J, Schmid AM, Schmidt AM, Dale AM, Hämäläinen MS, Marinkovic K, Schacter DL, Rosen BR, Halgren E.Top-down facilitation of visual recognition.Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):449-54.
  • Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J.Self-assembling protein microarrays.Science. 2004 Jul 2;305(5680):86-90.
  • Lev MH, Ozsunar Y, Henson JW, Rasheed AA, Barest GD, Harsh GR, Fitzek MM, Chiocca EA, Rabinov JD, Csavoy AN, Rosen BR, Hochberg FH, Schaefer PW, Gonzalez RG.Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected].AJNR Am J Neuroradiol. 2004 Feb;25(2):214-21.
  • Fung WL, Risch H, McLaughlin J, Rosen B, Cole D, Vesprini D, Narod SA.The N314D polymorphism of galactose-1-phosphate uridyl transferase does not modify the risk of ovarian cancer.Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):678-80.
  • Bayani J, Brenton JD, Macgregor PF, Beheshti B, Albert M, Nallainathan D, Karaskova J, Rosen B, Murphy J, Laframboise S, Zanke B, Squire JA.Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression microarrays.Cancer Res. 2002 Jun 15;62(12):3466-76.
  • Yamada K, Wu O, Gonzalez RG, Bakker D, Østergaard L, Copen WA, Weisskoff RM, Rosen BR, Yagi K, Nishimura T, Sorensen AG.Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy.Stroke. 2002 Jan;33(1):87-94.
  • Zaharchuk G, Ledden PJ, Kwong KK, Reese TG, Rosen BR, Wald LL.Multislice perfusion and perfusion territory imaging in humans with separate label and image coils.Magn Reson Med. 1999 Jun;41(6):1093-8.
  • Ostergaard L, Chesler DA, Weisskoff RM, Sorensen AG, Rosen BR.Modeling cerebral blood flow and flow heterogeneity from magnetic resonance residue data.J Cereb Blood Flow Metab. 1999 Jun;19(6):690-9.
  • Rauch SL, Whalen PJ, Savage CR, Curran T, Kendrick A, Brown HD, Bush G, Breiter HC, Rosen BR.Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging.Hum Brain Mapp. 1997;5(2):124-32.
  • Bandettini PA, Kwong KK, Davis TL, Tootell RB, Wong EC, Fox PT, Belliveau JW, Weisskoff RM, Rosen BR.Characterization of cerebral blood oxygenation and flow changes during prolonged brain activation.Hum Brain Mapp. 1997;5(2):93-109.
  • Marota JJ, Ayata C, Moskowitz MA, Weisskoff RM, Rosen BR, Mandeville JB.Investigation of the early response to rat forepaw stimulation.Magn Reson Med. 1999 Feb;41(2):247-52.
  • Ostergaard L, Hochberg FH, Rabinov JD, Sorensen AG, Lev M, Kim L, Weisskoff RM, Gonzalez RG, Gyldensted C, Rosen BR.Early changes measured by magnetic resonance imaging in cerebral blood flow, blood volume, and blood-brain barrier permeability following dexamethasone treatment in patients with brain tumors.J Neurosurg. 1999 Feb;90(2):300-5.
  • Chee MW, O'Craven KM, Bergida R, Rosen BR, Savoy RL.Auditory and visual word processing studied with fMRI.Hum Brain Mapp. 1999;7(1):15-28.
  • Dennie J, Mandeville JB, Boxerman JL, Packard SD, Rosen BR, Weisskoff RM.NMR imaging of changes in vascular morphology due to tumor angiogenesis.Magn Reson Med. 1998 Dec;40(6):793-9.
  • Seidman LJ, Breiter HC, Goodman JM, Goldstein JM, Woodruff PW, O'Craven K, Savoy R, Tsuang MT, Rosen BR.A functional magnetic resonance imaging study of auditory vigilance with low and high information processing demands.Neuropsychology. 1998 Oct;12(4):505-18.
  • Casey BJ, Cohen JD, O'Craven K, Davidson RJ, Irwin W, Nelson CA, Noll DC, Hu X, Lowe MJ, Rosen BR, Truwitt CL, Turski PA.Reproducibility of fMRI results across four institutions using a spatial working memory task.Neuroimage. 1998 Oct;8(3):249-61.
  • Bush G, Whalen PJ, Rosen BR, Jenike MA, McInerney SC, Rauch SL.The counting Stroop: an interference task specialized for functional neuroimaging--validation study with functional MRI.Hum Brain Mapp. 1998;6(4):270-82.
  • Guimaraes AR, Melcher JR, Talavage TM, Baker JR, Ledden P, Rosen BR, Kiang NY, Fullerton BC, Weisskoff RM.Imaging subcortical auditory activity in humans.Hum Brain Mapp. 1998;6(1):33-41.
  • Keltner JR, Wald LL, Ledden PJ, Chen YC, Matthews RT, Küestermann EH, Baker JR, Rosen BR, Jenkins BG.A localized double-quantum filter for the in vivo detection of brain glucose.Magn Reson Med. 1998 Apr;39(4):651-6.
  • Mandeville JB, Marota JJ, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM.Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation.Magn Reson Med. 1998 Apr;39(4):615-24.
  • Davis TL, Kwong KK, Weisskoff RM, Rosen BR.Calibrated functional MRI: mapping the dynamics of oxidative metabolism.Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1834-9.
  • Caramia F, Huang Z, Hamberg LM, Weisskoff RM, Zaharchuk G, Moskowitz MA, Cavagna FM, Rosen BR.Mismatch between cerebral blood volume and flow index during transient focal ischemia studied with MRI and GD-BOPTA.Magn Reson Imaging. 1998;16(2):97-103.
  • Cutrer FM, Sorensen AG, Weisskoff RM, Ostergaard L, Sanchez del Rio M, Lee EJ, Rosen BR, Moskowitz MA.Perfusion-weighted imaging defects during spontaneous migrainous aura.Ann Neurol. 1998 Jan;43(1):25-31.
  • Matthews RT, Yang L, Jenkins BG, Ferrante RJ, Rosen BR, Kaddurah-Daouk R, Beal MF.Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.J Neurosci. 1998 Jan 1;18(1):156-63.
  • Caramia F, Yoshida T, Hamberg LM, Huang Z, Hunter G, Wanke I, Zaharchuk G, Moskowitz MA, Rosen BR.Measurement of changes in cerebral blood volume in spontaneously hypertensive rats following L-arginine infusion using dynamic susceptibility contrast MRI.Magn Reson Med. 1998 Jan;39(1):160-3.
  • Cramer SC, Nelles G, Benson RR, Kaplan JD, Parker RA, Kwong KK, Kennedy DN, Finklestein SP, Rosen BR.A functional MRI study of subjects recovered from hemiparetic stroke.Stroke. 1997 Dec;28(12):2518-27.
  • Makris N, Worth AJ, Sorensen AG, Papadimitriou GM, Wu O, Reese TG, Wedeen VJ, Davis TL, Stakes JW, Caviness VS, Kaplan E, Rosen BR, Pandya DN, Kennedy DN.Morphometry of in vivo human white matter association pathways with diffusion-weighted magnetic resonance imaging.Ann Neurol. 1997 Dec;42(6):951-62.
  • Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG.Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data.Magn Reson Med. 1997 Sep;38(3):389-98.
  • Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE.Acute effects of cocaine on human brain activity and emotion.Neuron. 1997 Sep;19(3):591-611.
  • Boxerman JL, Rosen BR, Weisskoff RM.Signal-to-noise analysis of cerebral blood volume maps from dynamic NMR imaging studies.J Magn Reson Imaging. 1997 May-Jun;7(3):528-37.
  • Lev MH, Kulke SF, Sorensen AG, Boxerman JL, Brady TJ, Rosen BR, Buchbinder BR, Weisskoff RM.Contrast-to-noise ratio in functional MRI of relative cerebral blood volume with sprodiamide injection.J Magn Reson Imaging. 1997 May-Jun;7(3):523-7.
  • Schulz JB, Panahian N, Chen YI, Beal MF, Moskowitz MA, Rosen BR, Jenkins BG.Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques.Am J Physiol. 1997 Apr;272(4 Pt 2):H1986-95.
  • Pierce AR, Lo EH, Mandeville JB, Gonzalez RG, Rosen BR, Wolf GL.MRI measurements of water diffusion and cerebral perfusion: their relationship in a rat model of focal cerebral ischemia.J Cereb Blood Flow Metab. 1997 Feb;17(2):183-90.
  • Koroshetz WJ, Jenkins BG, Rosen BR, Beal MF.Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.Ann Neurol. 1997 Feb;41(2):160-5.
  • Sorensen AG, Tievsky AL, Ostergaard L, Weisskoff RM, Rosen BR.Contrast agents in functional MR imaging.J Magn Reson Imaging. 1997 Jan-Feb;7(1):47-55.
  • Niemi P, Aronen HJ, Kwong KK, Gazit IE, Pardo FS, Rosen BR.Inverse correlation between T1 relaxation times before and after administration of contrast media in malignant brain tumors.Acad Radiol. 1996 Aug;3 Suppl 2:S286-8.
  • Aronen HJ, Glass J, Pardo FS, Belliveau JW, Gruber ML, Buchbinder BR, Gazit IE, Linggood RM, Fischman AJ, Rosen BR.Echo-planar MR cerebral blood volume mapping of gliomas. Clinical utility.Acta Radiol. 1995 Sep;36(5):520-8.