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Christopher A. Walsh, MD, PhD

Publications

  • Yang YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J, Tatarakis A, Mahajan MA, Samuels HH, Shi Y, Golden JA, Mahajnah M, Shenhav R, Walsh CA.Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.Cell. 2012 Nov 21;151(5):1097-112.
    23178126
  • Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, Lamantia AS, Walsh CA.The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.Neuron. 2011 Mar 10;69(5):893-905.
    21382550
  • Ching MS, Shen Y, Tan WH, Jeste SS, Morrow EM, Chen X, Mukaddes NM, Yoo SY, Hanson E, Hundley R, Austin C, Becker RE, Berry GT, Driscoll K, Engle EC, Friedman S, Gusella JF, Hisama FM, Irons MB, Lafiosca T, LeClair E, Miller DT, Neessen M, Picker JD, Rappaport L, Rooney CM, Sarco DP, Stoler JM, Walsh CA, Wolff RR, Zhang T, Nasir RH, Wu BL, .Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders.Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):937-47.
    20468056
  • Lizarraga SB, Margossian SP, Harris MH, Campagna DR, Han AP, Blevins S, Mudbhary R, Barker JE, Walsh CA, Fleming MD.Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors.Development. 2010 Jun;137(11):1907-17.
    20460369
  • Shen Y, Dies KA, Holm IA, Bridgemohan C, Sobeih MM, Caronna EB, Miller KJ, Frazier JA, Silverstein I, Picker J, Weissman L, Raffalli P, Jeste S, Demmer LA, Peters HK, Brewster SJ, Kowalczyk SJ, Rosen-Sheidley B, McGowan C, Duda AW, Lincoln SA, Lowe KR, Schonwald A, Robbins M, Hisama F, Wolff R, Becker R, Nasir R, Urion DK, Milunsky JM, Rappaport L, Gusella JF, Walsh CA, Wu BL, Miller DT, .Clinical Genetic Testing for Patients With Autism Spectrum Disorders.Pediatrics. 2010 Apr;125(4):e727-35.
    20231187
  • Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA.Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.Nat Genet. 2010 Mar;42(3):245-9.
    20118933
  • Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D.Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.Development. 2010 Jan;137(2):249-59.
    20040491
  • Mochida GH, Mahajnah M, Hill AD, Basel-Vanagaite L, Gleason D, Hill RS, Bodell A, Crosier M, Straussberg R, Walsh CA.A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly.Am J Hum Genet. 2009 Dec;85(6):897-902.
    20004763
  • Yu F, Keinan A, Chen H, Ferland RJ, Hill RS, Mignault AA, Walsh CA, Reich D.Detecting natural selection by empirical comparison to random regions of the genome.Hum Mol Genet. 2009 Dec 15;18(24):4853-67.
    19783549
  • Frueh DP, Arthanari H, Koglin A, Walsh CT, Wagner G.A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins.J Am Chem Soc. 2009 Sep 16;131(36):12880-1.
    19702261
  • Parrini E,Ferrari AR,Dorn T,Walsh CA,Guerrini R.Bilateral frontoparietal polymicrogyria, Lennox-Gastaut syndrome, and GPR56 gene mutations.Epilepsia. 2009 Jun;50(6):1344-53.
    19016831
  • Huang Z,Kawase-Koga Y,Zhang S,Visvader J,Toth M,Walsh CA,Sun T.Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control.Dev Biol. 2009 Mar 1;327(1):132-42.
    19111533
  • Alazami AM,Al-Saif A,Al-Semari A,Bohlega S,Zlitni S,Alzahrani F,Bavi P,Kaya N,Colak D,Khalak H,Baltus A,Peterlin B,Danda S,Bhatia KP,Schneider SA,Sakati N,Walsh CA,Al-Mohanna F,Meyer B,Alkuraya FS.Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.Am J Hum Genet. 2008 Dec;83(6):684-91.
    19026396
  • Manzini MC,Gleason D,Chang BS,Hill RS,Barry BJ,Partlow JN,Poduri A,Currier S,Galvin-Parton P,Shapiro LR,Schmidt K,Davis JG,Basel-Vanagaite L,Seidahmed MZ,Salih MA,Dobyns WB,Walsh CA.Ethnically diverse causes of Walker-Warburg syndrome (WWS): FCMD mutations are a more common cause of WWS outside of the Middle East.Hum Mutat. 2008 Nov;29(11):E231-41.
    18752264
  • Pawlisz AS, Mutch C, Wynshaw-Boris A, Chenn A, Walsh CA, Feng Y.Lis1-Nde1 dependent neuronal fate control determines cerebral cortical size and lamination.Hum Mol Genet. 2008 Aug 15;17(16):2441-55.
    18469343
  • Sepp KJ,Hong P,Lizarraga SB,Liu JS,Mejia LA,Walsh CA,Perrimon N.Identification of neural outgrowth genes using genome-wide RNAi.PLoS Genet. 2008 Jul;4(7):e1000111.
    18604272
  • Kantarci S,Ragge NK,Thomas NS,Robinson DO,Noonan KM,Russell MK,Donnai D,Raymond FL,Walsh CA,Donahoe PK,Pober BR.Donnai-Barrow syndrome (DBS/FOAR) in a child with a homozygous LRP2 mutation due to complete chromosome 2 paternal isodisomy.Am J Med Genet A. 2008 Jul 15;146A(14):1842-7.
    18553518
  • Dobyns WB,Mirzaa G,Christian SL,Petras K,Roseberry J,Clark GD,Curry CJ,McDonald-McGinn D,Medne L,Zackai E,Parsons J,Zand DJ,Hisama FM,Walsh CA,Leventer RJ,Martin CL,Gajecka M,Shaffer LG.Consistent chromosome abnormalities identify novel polymicrogyria loci in 1p36.3, 2p16.1-p23.1, 4q21.21-q22.1, 6q26-q27, and 21q2.Am J Med Genet A. 2008 Jul 1;146A(13):1637-54.
    18536050
  • Li S,Jin Z,Koirala S,Bu L,Xu L,Hynes RO,Walsh CA,Corfas G,Piao X.GPR56 regulates pial basement membrane integrity and cortical lamination.J Neurosci. 2008 May 28;28(22):5817-26.
    18509043
  • Cubelos B,Sebastian-Serrano A,Kim S,Moreno-Ortiz C,Redondo JM,Walsh CA,Nieto M.Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone.Cereb Cortex. 2008 Aug;18(8):1758-70.
    18033766
  • Balibar CJ, Walsh CT.From thioesters to amides and back: condensation domain reversibility in the biosynthesis of vibriobactin.Chembiochem. 2008 Jan 4;9(1):42-5.
    18022888
  • Shen Y, Irons M, Miller DT, Cheung SW, Lip V, Sheng X, Tomaszewicz K, Shao H, Fang H, Tang HS, Irons M, Walsh CA, Platt O, Gusella JF, Wu BL.Development of a focused oligonucleotide-array comparative genomic hybridization chip for clinical diagnosis of genomic imbalance.Clin Chem. 2007 Dec;53(12):2051-9.
    17901113
  • Lu W, Quintero-Rivera F, Fan Y, Alkuraya FS, Donovan DJ, Xi Q, Turbe-Doan A, Li QG, Campbell CG, Shanske AL, Sherr EH, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh CA, Gronostajski RM, Devriendt K, Higgins A, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL.NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.PLoS Genet. 2007 May 25;3(5):e80.
    17530927
  • Friocourt G, Liu JS, Antypa M, Rakic S, Walsh CA, Parnavelas JG.Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration.J Neurosci. 2007 Apr 4;27(14):3875-83.
    17409252
  • Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA.Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41.
    17172441
  • Basel-Vanagaite L, Muncher L, Straussberg R, Pasmanik-Chor M, Yahav M, Rainshtein L, Walsh CA, Magal N, Taub E, Drasinover V, Shalev H, Attia R, Rechavi G, Simon AJ, Shohat M.Mutated nup62 causes autosomal recessive infantile bilateral striatal necrosis.Ann Neurol. 2006 Aug;60(2):214-22.
    16786527
  • Neal J, Apse K, Sahin M, Walsh CA, Sheen VL.Deletion of chromosome 1p36 is associated with periventricular nodular heterotopia.Am J Med Genet A. 2006 Aug 1;140(15):1692-5.
    16835933
  • Sun T, Walsh CA.Molecular approaches to brain asymmetry and handedness.Nat Rev Neurosci. 2006 Aug;7(8):655-62. Review.
    16858393
  • Sun T, Collura RV, Ruvolo M, Walsh CA.Genomic and evolutionary analyses of asymmetrically expressed genes in human fetal left and right cerebral cortex.Cereb Cortex. 2006 Jul;16 Suppl 1:i18-25.
    16766703
  • Rajab A, Yoo SY, Abdulgalil A, Kathiri S, Ahmed R, Mochida GH, Bodell A, Barkovich AJ, Walsh CA.An autosomal recessive form of spastic cerebral palsy (CP) with microcephaly and mental retardation.Am J Med Genet A. 2006 Jul 15;140(14):1504-10.
    16761294
  • Ferland RJ, Gaitanis JN, Apse K, Tantravahi U, Walsh CA, Sheen VL.Periventricular nodular heterotopia and Williams syndrome.Am J Med Genet A. 2006 Jun 15;140(12):1305-11.
    16691586
  • Parrini E, Ramazzotti A, Dobyns WB, Mei D, Moro F, Veggiotti P, Marini C, Brilstra EH, Dalla Bernardina B, Goodwin L, Bodell A, Jones MC, Nangeroni M, Palmeri S, Said E, Sander JW, Striano P, Takahashi Y, Van Maldergem L, Leonardi G, Wright M, Walsh CA, Guerrini R.Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations.Brain. 2006 Jul;129(Pt 7):1892-906.
    16684786
  • Sheen VL, Ferland RJ, Harney M, Hill RS, Neal J, Banham AH, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA.Impaired proliferation and migration in human Miller-Dieker neural precursors.Ann Neurol. 2006 Apr 26;60(1):137-144.
    16642511
  • Tsao JW, Neal J, Apse K, Stephan MJ, Dobyns WB, Hill RS, Walsh CA, Sheen VL.Cerebellar ataxia with progressive improvement.Arch Neurol. 2006 Apr;63(4):594-7.
    16606775
  • Olson EC, Kim S, Walsh CA.Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression.J Neurosci. 2006 Feb 8;26(6):1767-75.
    16467525
  • Sheen VL, Ferland RJ, Neal J, Harney M, Hill RS, Banham A, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA.Neocortical neuronal arrangement in Miller Dieker syndrome.Acta Neuropathol. 2006 May;111(5):489-96.
    16456669
  • Chang BS, Apse KA, Caraballo R, Cross JH, Mclellan A, Jacobson RD, Valente KD, Barkovich AJ, Walsh CA.A familial syndrome of unilateral polymicrogyria affecting the right hemisphere.Neurology. 2006 Jan 10;66(1):133-5.
    16401865
  • Deuel TA, Liu JS, Corbo JC, Yoo SY, Rorke-Adams LB, Walsh CA.Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth.Neuron. 2006 Jan 5;49(1):41-53.
    16387638
  • Piao X, Chang BS, Bodell A, Woods K, Benzeev B, Topcu M, Guerrini R, Goldberg-Stern H, Sztriha L, Dobyns WB, Barkovich AJ, Walsh CA.Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes.Ann Neurol. 2005 Nov;58(5):680-7.
    16240336
  • Hill RS, Walsh CA.Molecular insights into human brain evolution.Nature. 2005 Sep 1;437(7055):64-7.
    16136130
  • Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA.Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.Science. 2005 Jun 17;308(5729):1794-8.
    15894532
  • Shen J, Walsh CA.Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice.Mol Cell Biol. 2005 May;25(9):3639-47.
    15831469
  • Feng Y, Walsh CA.Mitotic spindle regulation by Nde1 controls cerebral cortical size.Neuron. 2004 Oct 14;44(2):279-93.
    15473967
  • Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Déscarie JC, Barkovich AJ, Walsh CA.G protein-coupled receptor-dependent development of human frontal cortex.Science. 2004 Mar 26;303(5666):2033-6.
    15044805