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Christopher A. Walsh, MD, PhD

Publications

  • Zhang X, Ling J, Barcia G, Jing L, Wu J, Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q, Poduri A, Partlow JN, Ville D, Dulac O, Yu TW, Lam AT, Servattalab S, Rodriguez J, Boddaert N, Munnich A, Colleaux L, Zon LI, Söll D, Walsh CA, Nabbout R.Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures.Am J Hum Genet. 2014 Apr 3;94(4):547-58.
    24656866
  • Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Šestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA.Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.Science. 2014 Feb 14;343(6172):764-8.
    24531968
  • Poduri A, Evrony GD, Cai X, Walsh CA.Somatic mutation, genomic variation, and neurological disease.Science. 2013 Jul 5;341(6141):1237758. Review.
    23828942
  • Yu TW, Chahrour MH, Coulter ME, Jiralerspong S, Okamura-Ikeda K, Ataman B, Schmitz-Abe K, Harmin DA, Adli M, Malik AN, D'Gama AM, Lim ET, Sanders SJ, Mochida GH, Partlow JN, Sunu CM, Felie JM, Rodriguez J, Nasir RH, Ware J, Joseph RM, Hill RS, Kwan BY, Al-Saffar M, Mukaddes NM, Hashmi A, Balkhy S, Gascon GG, Hisama FM, LeClair E, Poduri A, Oner O, Al-Saad S, Al-Awadi SA, Bastaki L, Ben-Omran T, Teebi AS, Al-Gazali L, Eapen V, Stevens CR, Rappaport L, Gabriel SB, Markianos K, State MW, Greenberg ME, Taniguchi H, Braverman NE, Morrow EM, Walsh CA.Using whole-exome sequencing to identify inherited causes of autism.Neuron. 2013 Jan 23;77(2):259-73.
    23352163
  • Yang YJ, Baltus AE, Mathew RS, Murphy EA, Evrony GD, Gonzalez DM, Wang EP, Marshall-Walker CA, Barry BJ, Murn J, Tatarakis A, Mahajan MA, Samuels HH, Shi Y, Golden JA, Mahajnah M, Shenhav R, Walsh CA.Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.Cell. 2012 Nov 21;151(5):1097-112.
    23178126
  • Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA.CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.Nat Genet. 2012 Sep 30;44(11):1260-1264.
    23023333
  • Evrony GD, Cai X, Lee E, Hills LB, Elhosary PC, Lehmann HS, Parker JJ, Atabay KD, Gilmore EC, Poduri A, Park PJ, Walsh CA.Single-neuron sequencing analysis of l1 retrotransposition and somatic mutation in the human brain.Cell. 2012 Oct 26;151(3):483-96.
    23101622
  • Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, Lamantia AS, Walsh CA.The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.Neuron. 2011 Mar 10;69(5):893-905.
    21382550
  • Lizarraga SB, Margossian SP, Harris MH, Campagna DR, Han AP, Blevins S, Mudbhary R, Barker JE, Walsh CA, Fleming MD.Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors.Development. 2010 Jun;137(11):1907-17.
    20460369
  • Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA.Mutations in PNKP cause microcephaly, seizures and defects in DNA repair.Nat Genet. 2010 Mar;42(3):245-9.
    20118933
  • Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D.Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.Development. 2010 Jan;137(2):249-59.
    20040491
  • Mochida GH, Mahajnah M, Hill AD, Basel-Vanagaite L, Gleason D, Hill RS, Bodell A, Crosier M, Straussberg R, Walsh CA.A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly.Am J Hum Genet. 2009 Dec;85(6):897-902.
    20004763
  • Manzini MC,Gleason D,Chang BS,Hill RS,Barry BJ,Partlow JN,Poduri A,Currier S,Galvin-Parton P,Shapiro LR,Schmidt K,Davis JG,Basel-Vanagaite L,Seidahmed MZ,Salih MA,Dobyns WB,Walsh CA.Ethnically diverse causes of Walker-Warburg syndrome (WWS): FCMD mutations are a more common cause of WWS outside of the Middle East.Hum Mutat. 2008 Nov;29(11):E231-41.
    18752264
  • Pawlisz AS, Mutch C, Wynshaw-Boris A, Chenn A, Walsh CA, Feng Y.Lis1-Nde1 dependent neuronal fate control determines cerebral cortical size and lamination.Hum Mol Genet. 2008 Aug 15;17(16):2441-55.
    18469343
  • Li S,Jin Z,Koirala S,Bu L,Xu L,Hynes RO,Walsh CA,Corfas G,Piao X.GPR56 regulates pial basement membrane integrity and cortical lamination.J Neurosci. 2008 May 28;28(22):5817-26.
    18509043
  • Cubelos B,Sebastian-Serrano A,Kim S,Moreno-Ortiz C,Redondo JM,Walsh CA,Nieto M.Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone.Cereb Cortex. 2008 Aug;18(8):1758-70.
    18033766
  • Friocourt G, Liu JS, Antypa M, Rakic S, Walsh CA, Parnavelas JG.Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration.J Neurosci. 2007 Apr 4;27(14):3875-83.
    17409252
  • Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA.Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41.
    17172441
  • Basel-Vanagaite L, Muncher L, Straussberg R, Pasmanik-Chor M, Yahav M, Rainshtein L, Walsh CA, Magal N, Taub E, Drasinover V, Shalev H, Attia R, Rechavi G, Simon AJ, Shohat M.Mutated nup62 causes autosomal recessive infantile bilateral striatal necrosis.Ann Neurol. 2006 Aug;60(2):214-22.
    16786527
  • Neal J, Apse K, Sahin M, Walsh CA, Sheen VL.Deletion of chromosome 1p36 is associated with periventricular nodular heterotopia.Am J Med Genet A. 2006 Aug 1;140(15):1692-5.
    16835933
  • Sun T, Walsh CA.Molecular approaches to brain asymmetry and handedness.Nat Rev Neurosci. 2006 Aug;7(8):655-62. Review.
    16858393
  • Sun T, Collura RV, Ruvolo M, Walsh CA.Genomic and evolutionary analyses of asymmetrically expressed genes in human fetal left and right cerebral cortex.Cereb Cortex. 2006 Jul;16 Suppl 1:i18-25.
    16766703
  • Rajab A, Yoo SY, Abdulgalil A, Kathiri S, Ahmed R, Mochida GH, Bodell A, Barkovich AJ, Walsh CA.An autosomal recessive form of spastic cerebral palsy (CP) with microcephaly and mental retardation.Am J Med Genet A. 2006 Jul 15;140(14):1504-10.
    16761294
  • Ferland RJ, Gaitanis JN, Apse K, Tantravahi U, Walsh CA, Sheen VL.Periventricular nodular heterotopia and Williams syndrome.Am J Med Genet A. 2006 Jun 15;140(12):1305-11.
    16691586
  • Parrini E, Ramazzotti A, Dobyns WB, Mei D, Moro F, Veggiotti P, Marini C, Brilstra EH, Dalla Bernardina B, Goodwin L, Bodell A, Jones MC, Nangeroni M, Palmeri S, Said E, Sander JW, Striano P, Takahashi Y, Van Maldergem L, Leonardi G, Wright M, Walsh CA, Guerrini R.Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations.Brain. 2006 Jul;129(Pt 7):1892-906.
    16684786
  • Sheen VL, Ferland RJ, Harney M, Hill RS, Neal J, Banham AH, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA.Impaired proliferation and migration in human Miller-Dieker neural precursors.Ann Neurol. 2006 Apr 26;60(1):137-144.
    16642511
  • Tsao JW, Neal J, Apse K, Stephan MJ, Dobyns WB, Hill RS, Walsh CA, Sheen VL.Cerebellar ataxia with progressive improvement.Arch Neurol. 2006 Apr;63(4):594-7.
    16606775
  • Olson EC, Kim S, Walsh CA.Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression.J Neurosci. 2006 Feb 8;26(6):1767-75.
    16467525
  • Sheen VL, Ferland RJ, Neal J, Harney M, Hill RS, Banham A, Brown P, Chenn A, Corbo J, Hecht J, Folkerth R, Walsh CA.Neocortical neuronal arrangement in Miller Dieker syndrome.Acta Neuropathol. 2006 May;111(5):489-96.
    16456669
  • Chang BS, Apse KA, Caraballo R, Cross JH, Mclellan A, Jacobson RD, Valente KD, Barkovich AJ, Walsh CA.A familial syndrome of unilateral polymicrogyria affecting the right hemisphere.Neurology. 2006 Jan 10;66(1):133-5.
    16401865
  • Deuel TA, Liu JS, Corbo JC, Yoo SY, Rorke-Adams LB, Walsh CA.Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth.Neuron. 2006 Jan 5;49(1):41-53.
    16387638
  • Piao X, Chang BS, Bodell A, Woods K, Benzeev B, Topcu M, Guerrini R, Goldberg-Stern H, Sztriha L, Dobyns WB, Barkovich AJ, Walsh CA.Genotype-phenotype analysis of human frontoparietal polymicrogyria syndromes.Ann Neurol. 2005 Nov;58(5):680-7.
    16240336
  • Hill RS, Walsh CA.Molecular insights into human brain evolution.Nature. 2005 Sep 1;437(7055):64-7.
    16136130
  • Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA.Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.Science. 2005 Jun 17;308(5729):1794-8.
    15894532
  • Shen J, Walsh CA.Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice.Mol Cell Biol. 2005 May;25(9):3639-47.
    15831469
  • Feng Y, Walsh CA.Mitotic spindle regulation by Nde1 controls cerebral cortical size.Neuron. 2004 Oct 14;44(2):279-93.
    15473967
  • Piao X, Hill RS, Bodell A, Chang BS, Basel-Vanagaite L, Straussberg R, Dobyns WB, Qasrawi B, Winter RM, Innes AM, Voit T, Ross ME, Michaud JL, Dscarie JC, Barkovich AJ, Walsh CA.G protein-coupled receptor-dependent development of human frontal cortex.Science. 2004 Mar 26;303(5666):2033-6.
    15044805