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Martin Kulldorff, PhD


  • Maro JC, Brown JS, Dal Pan GJ, Kulldorff M.Minimizing signal detection time in postmarket sequential analysis: balancing positive predictive value and sensitivity.Pharmacoepidemiol Drug Saf. 2014 Apr 3.
  • Toh S, Gagne JJ, Rassen JA, Fireman BH, Kulldorff M, Brown JS.Confounding adjustment in comparative effectiveness research conducted within distributed research networks.Med Care. 2013 Aug;51(8 Suppl 3):S4-S10.
  • Abrams AM, Kleinman K, Kulldorff M.Gumbel based p-value approximations for spatial scan statistics.Int J Health Geogr. 2010;9:61.
  • Jung I, Kulldorff M, Richard OJ.A spatial scan statistic for multinomial data.Stat Med. 2010 Aug 15;29(18):1910-8.
  • Curriero FC, Kulldorff M, Boscoe FP, Klassen AC.Using imputation to provide location information for nongeocoded addresses.PLoS ONE. 2010;5(2):e8998.
  • Li L, Kulldorff M.A conditional maximized sequential probability ratio test for pharmacovigilance.Stat Med. 2010 Jan 30;29(2):284-95.
  • Kulldorff M, Huang L, Konty K.A scan statistic for continuous data based on the normal probability model.Int J Health Geogr. 2009;8:58.
  • Huang L, Tiwari R, Zuo J, Kulldorff M, Feuer E.Weighted normal spatial scan statistic for heterogenous population data.Journal of the American Statistical Association..
  • Hinrichsen VL, Klassen AC, Song C, Kulldorff M.Evaluation of the performance of tests for spatial randomness on prostate cancer data.Int J Health Geogr. 2009;8:41.
  • Brown JS,Kulldorff M,Petronis KR,Reynolds R,Chan KA,Davis RL,Graham D,Andrade SE,Raebel MA,Herrinton L,Roblin D,Boudreau D,Smith D,Gurwitz JH,Gunter MJ,Platt R.Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerations.Pharmacoepidemiol Drug Saf. 2009 Mar;18(3):226-34.
  • Brown JS,Kulldorff M,Chan KA,Davis RL,Graham D,Pettus PT,Andrade SE,Raebel MA,Herrinton L,Roblin D,Boudreau D,Smith D,Gurwitz JH,Gunter MJ,Platt R.Early detection of adverse drug events within population-based health networks: application of sequential testing methods.Pharmacoepidemiol Drug Saf. 2007 Dec;16(12):1275-84.
  • Gunter MJ, Divi RL, Kulldorff M, Vermeulen R, Haverkos KJ, Kuo MM, Strickland P, Poirier MC, Rothman N, Sinha R.Leukocyte Polycyclic Aromatic Hydrocarbon-DNA Adduct Formation and Colorectal Adenoma.Carcinogenesis. 2007 Jul;28(7):1426-9.
  • Gregorio DI, Huang L, Dechello LM, Samociuk H, Kulldorff M.Place of Residence Effect on Likelihood of Surviving Prostate Cancer.Ann Epidemiol. 2007 Jul;17(7):520-4.
  • Ward MH, Cross AJ, Divan H, Kulldorff M, Nowell-Kadlubar S, Kadlubar FF, Sinha R.Processed meat intake, CYP2A6 activity, and risk of colorectal adenoma.Carcinogenesis. 2007 Jun;28(6):1210-6.
  • Recuenco S, Eidson M, Kulldorff M, Johnson G, Cherry B.Spatial and temporal patterns of enzootic raccoon rabies adjusted for multiple covariates.Int J Health Geogr. 2007;6:14.
  • Rolka H, Burkom H, Cooper GF, Kulldorff M, Madigan D, Wong WK.Issues in applied statistics for public health bioterrorism surveillance using multiple data streams: research needs.Stat Med. 2007 Apr 15;26(8):1834-56.
  • Kulldorff M, Mostashari F, Duczmal L, Katherine Yih W, Kleinman K, Platt R.Multivariate scan statistics for disease surveillance.Stat Med. 2007 Apr 15;26(8):1824-33.
  • Lawson AB, Simeon S, Kulldorff M, Biggeri A, Magnani C .Line and point cluster models for spatial health data.Computational Statistics & Data Analysis.;51:6027-6043.
  • Huang L, Kulldorff M, Gregorio D.A spatial scan statistic for survival data.Biometrics. 2006 Sep 01;63:109-118.
  • Kulldorff M.for spatial randomness adjusting for an underlying inhomogeneity: A general framework.Journal of the American Statistical Association. 2006 Sep 01;In Press.
  • Jung I, Kulldorff M, Klassen AC.A spatial scan statistic for ordinal data.Stat Med. 2007 Mar 30;26(7):1594-607.
  • Klassen AC, Curriero F, Kulldorff M, Alberg AJ, Platz EA, Neloms ST.Missing stage and grade in Maryland prostate cancer surveillance data, 1992-1997.Am J Prev Med. 2006 Feb;30(2 Suppl):S77-87.
  • Kulldorff M, Song C, Gregorio D, Samociuk H, DeChello L.Cancer map patterns: are they random or not?.Am J Prev Med. 2006 Feb;30(2 Suppl):S37-49.
  • Kulldorff M, Huang L, Pickle L, Duczmal L.An elliptic spatial scan statistic.Stat Med. 2006 Nov 30;25(22):3929-43.
  • Assunção R, Tavares AI, Correa T, Kulldorff M.Space-time cluster identification in point processes.Canadian Journal of Statistics. 2007;35:9-25.
  • Jung I, Kulldorff M.Theoretical foundations of tests for spatial randomness.Canadian Journal of Statistics. 2007;26(7):1594-1607.
  • Duczmal L, Kulldorff M, Huang L.Evaluation of spatial scan statistics for irregularly shaped clusters.Journal of Computational and Graphical Statistics. 2006;15:428-442.
  • Glaz J, Kulldorff M, Pozdnyakov V, Steele JM.Gambling teams and waiting times for patterns in two-stage Markov chains.Journal of Applied Probability. 2006;43:127-140.
  • Kulldorff M.Tests for spatial randomness adjusting for an inhomogeneity: A general framework.JASA. 2006;101:1289-1305.
  • Gregorio DI, Dechello LM, Samociuk H, Kulldorff M.Lumping or splitting: seeking the preferred areal unit for health geography studies.Int J Health Geogr. 2005 Mar 23;4(1):6.
  • Kulldorff M, Heffernan R, Hartman J, Assunção R, Mostashari F.A Space-Time Permutation Scan Statistic for Disease Outbreak Detection.PLoS Med. 2005 Mar;2(3):e59.
  • Kulldorff M, Zhang Z, Hartman J, Heffernan R, Huang L, Mostashari F.Benchmark data and power calculations for evaluating disease outbreak detection methods.MMWR Morb Mortal Wkly Rep. 2004 Sep 24;53 Suppl:144-51.
  • Klassen AC, Kulldorff M, Curriero F.Geographical clustering of prostate cancer grade and stage at diagnosis, before and after adjustment for risk factors.Int J Health Geogr. 2005 Jan 13;4(1):1.
  • Gunter MJ, Probst-Hensch NM, Cortessis VK, Kulldorff M, Haile RW, Sinha R.Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study.Carcinogenesis. 2005 Mar;26(3):637-42.
  • Prestwood KM, Unson C, Kulldorff M, Cushman M.The effect of different doses of micronized 17beta-estradiol on C-reactive protein, interleukin-6, and lipids in older women.J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):827-32.
  • Klassen AC, Curriero FC, Hong JH, Williams C, Kulldorff M, Meissner HI, Alberg A, Ensminger M.The role of area-level influences on prostate cancer grade and stage at diagnosis.Prev Med. 2004 Sep;39(3):441-8.
  • Joseph Sheehan T, DeChello LM, Kulldorff M, Gregorio DI, Gershman S, Mroszczyk M.The geographic distribution of breast cancer incidence in Massachusetts 1988 to 1997, adjusted for covariates.Int J Health Geogr. 2004 Aug 3;3(1):17.
  • Fang Z, Kulldorff M, Gregorio DI.Brain cancer mortality in the United States, 1986 to 1995: a geographic analysis.Neuro-oncol. 2004 Jul;6(3):179-87.
  • Heffernan R, Mostashari F, Das D, Karpati A, Kulldorff M, Weiss D.Syndromic surveillance in public health practice, New York City.Emerg Infect Dis. 2004 May;10(5):858-64.
  • Gregorio DI, Kulldorff M, Sheehan TJ, Samociuk H.Geographic distribution of prostate cancer incidence in the era of PSA testing, Connecticut, 1984 to 1998.Urology. 2004 Jan;63(1):78-82.
  • Peters U, Sinha R, Bell DA, Rothman N, Grant DJ, Watson MA, Kulldorff M, Brooks LR, Warren SH, DeMarini DM.Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study.Environ Mol Mutagen. 2004;43(1):53-74.
  • Fang LQ, Cao WC, Dun Z, Wu XM, Sun PY, Kulldorff M, Wang BC, Yang H, Li XW.[Spatial analysis on the distribution of hemorrhagic fever with renal syndrome by geographic information system in Haidian district, Beijing].Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Nov;24(11):1020-3.
  • Song C, Kulldorff M.Power evaluation of disease clustering tests.Int J Health Geogr. 2003 Dec 19;2(1):9.
  • Mathew A, Peters U, Chatterjee N, Kulldorff M, Sinha R.Fat, fiber, fruits, vegetables, and risk of colorectal adenomas.Int J Cancer. 2004 Jan 10;108(2):287-92.
  • Prestwood KM, Kenny AM, Kleppinger A, Kulldorff M.Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women: a randomized controlled trial.JAMA. 2003 Aug 27;290(8):1042-8.
  • Kulldorff M, Fang Z, Walsh SJ.A tree-based scan statistic for database disease surveillance.Biometrics. 2003 Jun;59(2):323-31.
  • Mostashari F, Kulldorff M, Hartman JJ, Miller JR, Kulasekera V.Dead bird clusters as an early warning system for West Nile virus activity.Emerg Infect Dis. 2003 Jun;9(6):641-6.
  • Peters U, Sinha R, Chatterjee N, Subar AF, Ziegler RG, Kulldorff M, Bresalier R, Weissfeld JL, Flood A, Schatzkin A, Hayes RB,.Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme.Lancet. 2003 May 3;361(9368):1491-5.
  • Fang Z, Smith JA, Kleppinger A, Reisine ST, Emerson D, Kulldorff M.Retrospective evaluation and adjustment of dual energy X-ray absorptiometry measurements for bone mineral density research studies.J Clin Densitom. 2002 Winter;5(4):421-33.
  • Oncken C, Prestwood K, Cooney JL, Unson C, Fall P, Kulldorff M, Raisz LG.Effects of smoking cessation or reduction on hormone profiles and bone turnover in postmenopausal women.Nicotine Tob Res. 2002 Nov;4(4):451-8.
  • Anderson KE, Sinha R, Kulldorff M, Gross M, Lang NP, Barber C, Harnack L, DiMagno E, Bliss R, Kadlubar FF.Meat intake and cooking techniques: associations with pancreatic cancer.Mutat Res. 2002 Sep 30;506-507:225-31.
  • Jemal A, Kulldorff M, Devesa SS, Hayes RB, Fraumeni JF.A geographic analysis of prostate cancer mortality in the United States, 1970-89.Int J Cancer. 2002 Sep 10;101(2):168-74.
  • Gregorio DI, Kulldorff M, Barry L, Samociuk H.Geographic differences in invasive and in situ breast cancer incidence according to precise geographic coordinates, Connecticut, 1991-95.Int J Cancer. 2002 Jul 10;100(2):194-8.
  • Kulldorff M.Geographical distribution of sporadic Creutzfeldt-Jakob Disease in France.Int J Epidemiol. 2002 Apr;31(2):495-6.
  • Ishibe N, Sinha R, Hein DW, Kulldorff M, Strickland P, Fretland AJ, Chow WH, Kadlubar FF, Lang NP, Rothman N.Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.Pharmacogenetics. 2002 Mar;12(2):145-50.
  • Gregorio DI, Kulldorff M, Barry L, Samocuik H, Zarfos K.Geographical differences in primary therapy for early-stage breast cancer.Ann Surg Oncol. 2001 Dec;8(10):844-9.
  • Sinha R, Kulldorff M, Chow WH, Denobile J, Rothman N.Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenomas.Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62.
  • Kulldorff M, Hjalmars U.The Knox method and other tests for space-time interaction.Biometrics. 1999 Jun;55(2):544-52.
  • Prestwood KM, Kenny AM, Unson C, Kulldorff M.The effect of low dose micronized 17ss-estradiol on bone turnover, sex hormone levels, and side effects in older women: a randomized, double blind, placebo-controlled study.J Clin Endocrinol Metab. 2000 Dec;85(12):4462-9.
  • Kulldorff M, Sinha R, Chow WH, Rothman N.Comparing odds ratios for nested subsets of dietary components.Int J Epidemiol. 2000 Dec;29(6):1060-4.
  • Kulldorff M.Mathematical formula for Swartz' Entropy Test Statistic.Health Place. 1999 Dec;5(4):313.
  • Jemal A, Devesa S, Kulldorff M, Hayes R, Fraumeni J.Geographic variation in prostate cancer mortality rates among white males in the united states.Ann Epidemiol. 2000 Oct 1;10(7):470.
  • Talbot TO, Kulldorff M, Forand SP, Haley VB.Evaluation of spatial filters to create smoothed maps of health data.Stat Med. 2000 Sep 15-30;19(17-18):2399-408.
  • Sinha R, Gustafson DR, Kulldorff M, Wen WQ, Cerhan JR, Zheng W.2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a carcinogen in high-temperature-cooked meat, and breast cancer risk.J Natl Cancer Inst. 2000 Aug 16;92(16):1352-4.
  • Kulldorff M, McShane LM, Schatzkin A, Freedman LS, Wargovich MJ, Woods C, Purewal M, Burt RW, Lawson M, Mateski DJ, Lanza E, Corle DK, O'Brien B, Moler J.Measuring cell proliferation in the rectal mucosa. comparing bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) assays.J Clin Epidemiol. 2000 Aug;53(8):875-83.
  • Subar AF, Midthune D, Kulldorff M, Brown CC, Thompson FE, Kipnis V, Schatzkin A.Evaluation of alternative approaches to assign nutrient values to food groups in food frequency questionnaires.Am J Epidemiol. 2000 Aug 1;152(3):279-86.
  • Sinha R, Kulldorff M, Swanson CA, Curtin J, Brownson RC, Alavanja MC.Dietary heterocyclic amines and the risk of lung cancer among Missouri women.Cancer Res. 2000 Jul 15;60(14):3753-6.
  • Velie E, Kulldorff M, Schairer C, Block G, Albanes D, Schatzkin A.Dietary fat, fat subtypes, and breast cancer in postmenopausal women: a prospective cohort study.J Natl Cancer Inst. 2000 May 17;92(10):833-9.
  • Kulldorff M.Geographic information systems (GIS) and community health: some statistical issues.J Public Health Manag Pract. 1999 Mar;5(2):100-6.
  • Velie EM, Block G, Shaw GM, Samuels SJ, Schaffer DM, Kulldorff M.Maternal supplemental and dietary zinc intake and the occurrence of neural tube defects in California.Am J Epidemiol. 1999 Sep 15;150(6):605-16.
  • Sinha R, Chow WH, Kulldorff M, Denobile J, Butler J, Garcia-Closas M, Weil R, Hoover RN, Rothman N.Well-done, grilled red meat increases the risk of colorectal adenomas.Cancer Res. 1999 Sep 1;59(17):4320-4.
  • Kulldorff M, Graubard B, Velie E.The P-value and P-value function.Epidemiology. 1999 May;10(3):345-7.
  • Hjalmars U, Kulldorff M, Wahlqvist Y, Lannering B.Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973-1992: a population-based study of pediatric brain tumors.Cancer. 1999 May 1;85(9):2077-90.
  • Sinha R, Kulldorff M, Curtin J, Brown CC, Alavanja MC, Swanson CA.Fried, well-done red meat and risk of lung cancer in women (United States).Cancer Causes Control. 1998 Dec;9(6):621-30.
  • Kulldorff M, Athas WF, Feurer EJ, Miller BA, Key CR.Evaluating cluster alarms: a space-time scan statistic and brain cancer in Los Alamos, New Mexico.Am J Public Health. 1998 Sep;88(9):1377-80.
  • McShane LM, Kulldorff M, Wargovich MJ, Woods C, Purewal M, Freedman LS, Corle DK, Burt RW, Mateski DJ, Lawson M, Lanza E, O'Brien B, Lake W, Moler J, Schatzkin A.An evaluation of rectal mucosal proliferation measure variability sources in the polyp prevention trial: can we detect informative differences among individuals' proliferation measures amid the noise?.Cancer Epidemiol Biomarkers Prev. 1998 Jul;7(7):605-12.
  • Swanson CA, Brown CC, Sinha R, Kulldorff M, Brownson RC, Alavanja MC.Dietary fats and lung cancer risk among women: the Missouri Women's Health Study (United States).Cancer Causes Control. 1997 Nov;8(6):883-93.
  • Kulldorff M, Feuer EJ, Miller BA, Freedman LS.Breast cancer clusters in the northeast United States: a geographic analysis.Am J Epidemiol. 1997 Jul 15;146(2):161-70.
  • Hjalmars U, Kulldorff M, Gustafsson G, Nagarwalla N.Childhood leukaemia in Sweden: using GIS and a spatial scan statistic for cluster detection.Stat Med. 1996 Apr 15-May 15;15(7-9):707-15.
  • Abrahamsson A, Adami HO, Taube A, Kim K, Zelen M, Kulldorff M.Re: Long-term survival and mortality in prostate cancer treated with noncurative intent.J Urol. 1996 Jan;155(1):296-8.
  • Kulldorff M, Nagarwalla N.Spatial disease clusters: detection and inference.Stat Med. 1995 Apr 30;14(8):799-810.
  • Hjalmars U, Kulldorff M, Gustafsson G.Risk of acute childhood leukaemia in Sweden after the Chernobyl reactor accident. Swedish Child Leukaemia Group.BMJ. 1994 Jul 16;309(6948):154-7.