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Peter M. Howley, MD


  • French CA, Rahman S, Walsh EM, Kuhnle S, Grayson AR, Lemieux ME, Grunfeld N, Rubin BP, Antonescu CR, Zhang S, Venkatramani R, Dal Cin P, Howley PM.NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism.Cancer Discovery. 2014 May 29.
  • White EA, Walther J, Javanbakht H, Howley PM.Genus Beta HPV E6 Proteins Vary in their Effects on the Transactivation of p53 Target Genes.J Virol. 2014 May 21.
  • White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW, Howley PM.Comprehensive analysis of host cellular interactions with human papillomavirus e6 proteins identifies new e6 binding partners and reflects viral diversity.J Virol. 2012 Dec;86(24):13174-86.
  • Martínez-Noël G, Galligan JT, Sowa ME, Arndt V, Overton TM, Harper JW, Howley PM.Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.Mol Cell Biol. 2012 Aug;32(15):3095-106.
  • Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PM.Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):E1473-80.
  • Powell ML, Smith JA, Sowa ME, Harper JW, Iftner T, Stubenrauch F, Howley PM.NCoR1 Mediates Papillomavirus E8;E2C Transcriptional Repression.J Virol. 2010 May;84(9):4451-60.
  • Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM.Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3752-7.
  • Fradet-Turcotte A, Brault K, Titolo S, Howley PM, Archambault J.Characterization of papillomavirus E1 helicase mutants defective for interaction with the SUMO-conjugating enzyme Ubc9.Virology. 2009 Dec 20;395(2):190-201.
  • Ottinger M, Smith JA, Schweiger MR, Robbins D, Powell ML, You J, Howley PM.Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2.Virology. 2009 Dec 20;395(2):161-71.
  • You J, Li Q, Wu C, Kim J, Ottinger M, Howley PM.Regulation of aurora B expression by the bromodomain protein Brd4.Mol Cell Biol. 2009 Sep;29(18):5094-103.
  • Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM.Brd4 regulation of papillomavirus protein E2 stability.J Virol. 2009 Sep;83(17):8683-92.
  • Vos RM, Altreuter J, White EA, Howley PM.The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability.J Virol. 2009 Sep;83(17):8885-92.
  • Howley PM,Livingston DM.Small DNA tumor viruses: large contributors to biomedical sciences.Virology. 2009 Feb 20;384(2):256-9. Review.
  • Mulligan P,Westbrook TF,Ottinger M,Pavlova N,Chang B,Macia E,Shi YJ,Barretina J,Liu J,Howley PM,Elledge SJ,Shi Y.CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.Mol Cell. 2008 Dec 5;32(5):718-26.
  • Goh AM, Walters KJ, Elsasser S, Verma R, Deshaies RJ, Finley D, Howley PM.Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.BMC Biochem. 2008;9:4.
  • Schweiger MR, Ottinger M, You J, Howley PM.Brd4-independent transcriptional repression function of the papillomavirus e2 proteins.J Virol. 2007 Sep;81(18):9612-22.
  • DeMasi J, Chao MC, Kumar AS, Howley PM.Bovine papillomavirus E7 oncoprotein inhibits anoikis.J Virol. 2007 Sep;81(17):9419-25.
  • Schweiger MR, You J, Howley PM.Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function.J Virol. 2006 May;80(9):4276-85.
  • Li L, Li Z, Howley PM, Sacks DB.E6AP and calmodulin reciprocally regulate estrogen receptor stability.J Biol Chem. 2006 Jan 27;281(4):1978-85.
  • You J, Schweiger MR, Howley PM.Inhibition of e2 binding to brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells.J Virol. 2005 Dec;79(23):14956-61.
  • DeMasi J, Huh KW, Nakatani Y, Mnger K, Howley PM.Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding.Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11486-91.
  • Huh KW, DeMasi J, Ogawa H, Nakatani Y, Howley PM, Mnger K.Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11492-7.
  • Kirshner JR, Karpova AY, Kops M, Howley PM.Identification of TRAIL as an interferon regulatory factor 3 transcriptional target.J Virol. 2005 Jul;79(14):9320-4.
  • Bossis I, Roden RB, Gambhira R, Yang R, Tagaya M, Howley PM, Meneses PI.Interaction of tSNARE syntaxin 18 with the papillomavirus minor capsid protein mediates infection.J Virol. 2005 Jun;79(11):6723-31.
  • Walters KJ, Goh AM, Wang Q, Wagner G, Howley PM.Ubiquitin family proteins and their relationship to the proteasome: a structural perspective.Biochim Biophys Acta. 2004 Nov 29;1695(1-3):73-87.
  • Cooper EM, Hudson AW, Amos J, Wagstaff J, Howley PM.Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein (E6AP).J Biol Chem. 2004 Sep 24;279(39):41208-17.
  • You J, Croyle JL, Nishimura A, Ozato K, Howley PM.Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes.Cell. 2004 Apr 30;117(3):349-60.
  • Wang Q, Goh AM, Howley PM, Walters KJ.Ubiquitin recognition by the DNA repair protein hHR23a.Biochemistry. 2003 Nov 25;42(46):13529-35.
  • Hudson AW, Blom D, Howley PM, Ploegh HL.The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes.Traffic. 2003 Dec;4(12):824-37.
  • Walters KJ, Lech PJ, Goh AM, Wang Q, Howley PM.DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12694-9.
  • Kleijnen MF, Alarcon RM, Howley PM.The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome.Mol Biol Cell. 2003 Sep;14(9):3868-75.
  • Wells SI, Aronow BJ, Wise TM, Williams SS, Couget JA, Howley PM.Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7093-8.
  • Mnger K, Howley PM.Human papillomavirus immortalization and transformation functions.Virus Res. 2002 Nov;89(2):213-28.
  • Karpova AY, Trost M, Murray JM, Cantley LC, Howley PM.Interferon regulatory factor-3 is an in vivo target of DNA-PK.Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2818-23.
  • Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM.Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.Biochemistry. 2002 Feb 12;41(6):1767-77.
  • Hudson AW, Howley PM, Ploegh HL.A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes.J Virol. 2001 Dec;75(24):12347-58.
  • Karpova AY, Ronco LV, Howley PM.Functional characterization of interferon regulatory factor 3a (IRF-3a), an alternative splice isoform of IRF-3.Mol Cell Biol. 2001 Jul;21(13):4169-76.
  • Karpova AY, Howley PM, Ronco LV.Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene.Genes Dev. 2000 Nov 15;14(22):2813-8.
  • Wells SI, Francis DA, Karpova AY, Dowhanick JJ, Benson JD, Howley PM.Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.EMBO J. 2000 Nov 1;19(21):5762-71.
  • Zhou P, Bogacki R, McReynolds L, Howley PM.Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins.Mol Cell. 2000 Sep;6(3):751-6.
  • Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM.The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.Mol Cell. 2000 Aug;6(2):409-19.
  • Kao WH, Beaudenon SL, Talis AL, Huibregtse JM, Howley PM.Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.J Virol. 2000 Jul;74(14):6408-17.
  • Bellamy SJ, Gibberd R, Hancock L, Howley P, Kennedy B, Klar N, Lipsitz S, Ryan L.Analysis of dichotomous outcome data for community intervention studies.Stat Methods Med Res. 2000 Apr 01;9:135-159.
  • Nishimura A, Ono T, Ishimoto A, Dowhanick JJ, Frizzell MA, Howley PM, Sakai H.Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition.J Virol. 2000 Apr;74(8):3752-60.
  • Francis DA, Schmid SI, Howley PM.Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.J Virol. 2000 Mar;74(6):2679-86.
  • Harris KF, Shoji I, Cooper EM, Kumar S, Oda H, Howley PM.Ubiquitin-mediated degradation of active Src tyrosine kinase.Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13738-43.
  • Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP.Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.Science. 1999 Nov 12;286(5443):1321-6.
  • Oda H, Kumar S, Howley PM.Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9557-62.
  • Kumar S, Talis AL, Howley PM.Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.J Biol Chem. 1999 Jun 25;274(26):18785-92.
  • Unger T, Sionov RV, Moallem E, Yee CL, Howley PM, Oren M, Haupt Y.Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.Oncogene. 1999 May 27;18(21):3205-12.
  • Zhou P, Howley PM.Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases.Mol Cell. 1998 Nov;2(5):571-80.
  • Benson JD, Benson M, Howley PM, Struhl K.Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes.EMBO J. 1998 Nov 16;17(22):6714-22.
  • Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM.p300/MDM2 complexes participate in MDM2-mediated p53 degradation.Mol Cell. 1998 Oct;2(4):405-15.
  • Kasukawa H, Howley PM, Benson JD.A fifteen-amino-acid peptide inhibits human papillomavirus E1-E2 interaction and human papillomavirus DNA replication in vitro.J Virol. 1998 Oct;72(10):8166-73.
  • Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH.p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.J Biol Chem. 1998 Sep 11;273(37):24057-64.
  • Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T.Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.Mol Cell. 1998 Mar;1(4):507-18.
  • Ronco LV, Karpova AY, Vidal M, Howley PM.Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity.Genes Dev. 1998 Jul 1;12(13):2061-72.
  • Talis AL, Huibregtse JM, Howley PM.The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.J Biol Chem. 1998 Mar 13;273(11):6439-45.
  • Tong X, Salgia R, Li JL, Griffin JD, Howley PM.The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase.J Biol Chem. 1997 Dec 26;272(52):33373-6.
  • Tong X, Boll W, Kirchhausen T, Howley PM.Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1.J Virol. 1998 Jan;72(1):476-82.
  • Benson JD, Lawande R, Howley PM.Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins.J Virol. 1997 Oct;71(10):8041-7.
  • Yasugi T, Vidal M, Sakai H, Howley PM, Benson JD.Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins.J Virol. 1997 Aug;71(8):5942-51.
  • Kumar S, Kao WH, Howley PM.Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity.J Biol Chem. 1997 May 23;272(21):13548-54.
  • Tong X, Howley PM.The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4412-7.
  • Yamamoto Y, Huibregtse JM, Howley PM.The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing.Genomics. 1997 Apr 15;41(2):263-6.
  • Yasugi T, Benson JD, Sakai H, Vidal M, Howley PM.Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins.J Virol. 1997 Feb;71(2):891-9.
  • Howley PM, Gatehouse JA.A 38 bp repeat sequence within the pea seed storage protein promoter of legA is a binding site for a nuclear DNA-binding protein.Plant Mol Biol. 1997 Jan;33(1):175-80.
  • Maki CG, Howley PM.Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation.Mol Cell Biol. 1997 Jan;17(1):355-63.
  • Maki CG, Huibregtse JM, Howley PM.In vivo ubiquitination and proteasome-mediated degradation of p53(1).Cancer Res. 1996 Jun 1;56(11):2649-54.
  • Yasugi T, Howley PM.Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9.Nucleic Acids Res. 1996 Jun 1;24(11):2005-10.
  • Khleif SN, DeGregori J, Yee CL, Otterson GA, Kaye FJ, Nevins JR, Howley PM.Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4350-4.
  • Arbeit JM, Howley PM, Hanahan D.Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2930-5.
  • Sakai H, Yasugi T, Benson JD, Dowhanick JJ, Howley PM.Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.J Virol. 1996 Mar;70(3):1602-11.
  • Dowhanick JJ, McBride AA, Howley PM.Suppression of cellular proliferation by the papillomavirus E2 protein.J Virol. 1995 Dec;69(12):7791-9.
  • Benson JD, Howley PM.Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation.J Virol. 1995 Jul;69(7):4364-72.
  • Huibregtse JM, Scheffner M, Beaudenon S, Howley PM.A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.Proc Natl Acad Sci U S A. 1995 May 23;92(11):5249.
  • Huibregtse JM, Scheffner M, Beaudenon S, Howley PM.A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2563-7.
  • Vande Pol SB, Howley PM.Negative regulation of the bovine papillomavirus E5, E6, and E7 oncogenes by the viral E1 and E2 genes.J Virol. 1995 Jan;69(1):395-402.
  • Scheffner M, Huibregtse JM, Howley PM.Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8797-801.
  • Arbeit JM, Mnger K, Howley PM, Hanahan D.Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice.J Virol. 1994 Jul;68(7):4358-68.
  • Scheffner M, Romanczuk H, Mnger K, Huibregtse JM, Mietz JA, Howley PM.Functions of human papillomavirus proteins.Curr Top Microbiol Immunol. 1994;186:83-99.
  • Huibregtse JM, Scheffner M, Howley PM.E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins.Cold Spring Harb Symp Quant Biol. 1994;59:237-45.
  • Scheffner M, Huibregtse JM, Vierstra RD, Howley PM.The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53.Cell. 1993 Nov 5;75(3):495-505.
  • Unger T, Mietz JA, Scheffner M, Yee CL, Howley PM.Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.Mol Cell Biol. 1993 Sep;13(9):5186-94.
  • Huibregtse JM, Scheffner M, Howley PM.Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.Mol Cell Biol. 1993 Aug;13(8):4918-27.
  • Arbeit JM, Mnger K, Howley PM, Hanahan D.Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs.Am J Pathol. 1993 Apr;142(4):1187-97.
  • Huibregtse JM, Scheffner M, Howley PM.Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.Mol Cell Biol. 1993 Feb;13(2):775-84.
  • Mietz JA, Unger T, Huibregtse JM, Howley PM.The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.EMBO J. 1992 Dec;11(13):5013-20.
  • Del Vecchio AM, Romanczuk H, Howley PM, Baker CC.Transient replication of human papillomavirus DNAs.J Virol. 1992 Oct;66(10):5949-58.
  • McBride AA, Klausner RD, Howley PM.Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro.Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7531-5.
  • Lichy JH, Modi WS, Seuanez HN, Howley PM.Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells.Cell Growth Differ. 1992 Aug;3(8):541-8.
  • Scheffner M, Takahashi T, Huibregtse JM, Minna JD, Howley PM.Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins.J Virol. 1992 Aug;66(8):5100-5.
  • Scheffner M, Mnger K, Huibregtse JM, Howley PM.Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.EMBO J. 1992 Jul;11(7):2425-31.
  • Thierry F, Spyrou G, Yaniv M, Howley P.Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes.J Virol. 1992 Jun;66(6):3740-8.
  • Heck DV, Yee CL, Howley PM, Mnger K.Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.Proc Natl Acad Sci U S A. 1992 May 15;89(10):4442-6.
  • Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, Nevins JR.Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.Proc Natl Acad Sci U S A. 1992 May 15;89(10):4549-53.
  • Vande Pol SB, Howley PM.The bovine papillomavirus constitutive enhancer is essential for viral transformation, DNA replication, and the maintenance of latency.J Virol. 1992 Apr;66(4):2346-58.
  • Romanczuk H, Howley PM.Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3159-63.
  • Phelps WC, Mnger K, Yee CL, Barnes JA, Howley PM.Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.J Virol. 1992 Apr;66(4):2418-27.
  • Mnger K, Scheffner M, Huibregtse JM, Howley PM.Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.Cancer Surv. 1992;12:197-217.
  • McBride AA, Howley PM.Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number.J Virol. 1991 Dec;65(12):6528-34.
  • Huibregtse JM, Scheffner M, Howley PM.A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.EMBO J. 1991 Dec;10(13):4129-35.
  • Phelps WC, Bagchi S, Barnes JA, Raychaudhuri P, Kraus V, Mnger K, Howley PM, Nevins JR.Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.J Virol. 1991 Dec;65(12):6922-30.
  • Pietenpol JA, Mnger K, Howley PM, Stein RW, Moses HL.Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10227-31.
  • McBride AA, Romanczuk H, Howley PM.The papillomavirus E2 regulatory proteins.J Biol Chem. 1991 Oct 5;266(28):18411-4.
  • Howley PM.Role of the human papillomaviruses in human cancer.Cancer Res. 1991 Sep 15;51(18 Suppl):5019s-5022s.
  • Dostatni N, Lambert PF, Sousa R, Ham J, Howley PM, Yaniv M.The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex.Genes Dev. 1991 Sep;5(9):1657-71.
  • Mnger K, Yee CL, Phelps WC, Pietenpol JA, Moses HL, Howley PM.Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences.J Virol. 1991 Jul;65(7):3943-8.
  • Scheffner M, Mnger K, Byrne JC, Howley PM.The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5523-7.
  • Romanczuk H, Villa LL, Schlegel R, Howley PM.The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18.J Virol. 1991 May;65(5):2739-44.
  • Schiffman MH, Bauer HM, Lorincz AT, Manos MM, Byrne JC, Glass AG, Cadell DM, Howley PM.Comparison of Southern blot hybridization and polymerase chain reaction methods for the detection of human papillomavirus DNA.J Clin Microbiol. 1991 Mar;29(3):573-7.
  • Howley PM, Levine AJ, Li FP, Livingston DM, Rabson AS.Lack of SV40 DNA in tumors from scientists working with SV40 virus.N Engl J Med. 1991 Feb 14;324(7):494.
  • Spalholz BA, Vande Pol SB, Howley PM.Characterization of the cis elements involved in basal and E2-transactivated expression of the bovine papillomavirus P2443 promoter.J Virol. 1991 Feb;65(2):743-53.
  • Werness BA, Mnger K, Howley PM.Role of the human papillomavirus oncoproteins in transformation and carcinogenic progression.Important Adv Oncol. 1991:3-18.
  • Thierry F, Howley PM.Functional analysis of E2-mediated repression of the HPV18 P105 promoter.New Biol. 1991 Jan;3(1):90-100.
  • Howley PM.Tumor progression in transgenic mice containing the bovine papillomavirus genome.Basic Life Sci. 1991;57:103-7; discussion 108-10.
  • Howley PM, Scheffner M, Huibregtse J, Mnger K.Oncoproteins encoded by the cancer-associated human papillomaviruses target the products of the retinoblastoma and p53 tumor suppressor genes.Cold Spring Harb Symp Quant Biol. 1991;56:149-55.
  • Howley PM, Mnger K, Romanczuk H, Scheffner M, Huibregtse JM.Cellular targets of the oncoproteins encoded by the cancer associated human papillomaviruses.Virus Res. 1991;22:239-48.
  • Murphy CS, Pietenpol JA, Mnger K, Howley PM, Moses HL.c-myc and pRB: role in TGF-beta 1 inhibition of keratinocyte proliferation.Cold Spring Harb Symp Quant Biol. 1991;56:129-35.
  • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM.The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.Cell. 1990 Dec 21;63(6):1129-36.
  • Vande Pol SB, Howley PM.A bovine papillomavirus constitutive enhancer is negatively regulated by the E2 repressor through competitive binding for a cellular factor.J Virol. 1990 Nov;64(11):5420-9.
  • Pietenpol JA, Stein RW, Moran E, Yaciuk P, Schlegel R, Lyons RM, Pittelkow MR, Mnger K, Howley PM, Moses HL.TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.Cell. 1990 Jun 1;61(5):777-85.
  • Romanczuk H, Thierry F, Howley PM.Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters.J Virol. 1990 Jun;64(6):2849-59.
  • Werness BA, Levine AJ, Howley PM.Association of human papillomavirus types 16 and 18 E6 proteins with p53.Science. 1990 Apr 6;248(4951):76-9.
  • Lambert PF, Monk BC, Howley PM.Phenotypic analysis of bovine papillomavirus type 1 E2 repressor mutants.J Virol. 1990 Feb;64(2):950-6.