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Diane J. Mathis, PhD

Publications

  • Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK.Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.Immunity. 2014 Apr 17;40(4):569-81.
    24745333
  • Giraud M, Jmari N, Du L, Carallis F, Nieland TJ, Perez-Campo FM, Bensaude O, Root DE, Hacohen N, Mathis D, Benoist C.An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1491-6.
    24434558
  • Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM.Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.Cell. 2014 Jan 16;156(1-2):304-16.
    24439384
  • Ergun A, Doran G, Costello JC, Paik HH, Collins JJ, Mathis D, Benoist C, .Differential splicing across immune system lineages.Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14324-9.
    23934048
  • Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, , Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.Identification of transcriptional regulators in the mouse immune system.Nat Immunol. 2013 Apr 28.
    23624555
  • Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer M, Nolan G, Kobayashi K, von Boehmer H, Mathis D, Benoist C, , Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Rao TN, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.The transcriptional landscape of αβ T cell differentiation.Nat Immunol. 2013 May 5.
    23644507
  • Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D.Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.J Exp Med. 2013 May 6.
    23650440
  • Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF.Regulatory T cells: recommendations to simplify the nomenclature.Nat Immunol. 2013 Apr;14(4):307-8.
    23507634
  • Wakamatsu E, Mathis D, Benoist C.Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells.Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1023-8.
    23277554
  • Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom AR, Ma'ayan A, Chua WJ, Hansen TH, Turley SJ, Merad M, Randolph GJ, , Gautier EL, Jakubzick C, Randolph GJ, Best AJ, Knell J, Goldrath A, Miller J, Brown B, Merad M, Jojic V, Koller D, Cohen N, Brennan P, Brenner M, Shay T, Regev A, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S, Jianu R, Laidlaw D, Collins J, Narayan K, Sylvia K, Kang J, Gazit R, Garrison BS, Rossi DJ, Kim F, Rao TN, Wagers A, Shinton SA, Hardy RR, Monach P, Bezman NA, Sun JC, Kim CC, Lanier LL, Heng T, Kreslavsky T, Painter M, Ericson J, Davis S, Mathis D, Benoist C.Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.Nat Immunol. 2012 Sep 30;13(11):1118-1128.
    23023392
  • Benoist C, Lanier L, Merad M, Mathis D, .Consortium biology in immunology: the perspective from the Immunological Genome Project.Nat Rev Immunol. 2012 Oct;12(10):734-40.
    22955842
  • Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C.A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.Nat Immunol. 2012 Oct;13(10):972-80.
    22961053
  • Benoist C, Mathis D.Treg cells, life history, and diversity.Cold Spring Harb Perspect Biol. 2012 Sep;4(9):a007021.
    22952391
  • Bandukwala HS, Wu Y, Feurer M, Chen Y, Barbosa B, Ghosh S, Stroud JC, Benoist C, Mathis D, Rao A, Chen L.Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.Immunity. 2011 Mar 30.
    21458306
  • Painter MW, Davis S, Hardy RR, Mathis D, Benoist C, .Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.J Immunol. 2011 Mar 1;186(5):3047-57.
    21307297
  • Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sim S, Parent JM, Johnsen A, Mott R, Mathis D, Klenerman P, Benoist C, Flint J.A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus.PLoS Biol. 2010;8(12):e1000561.
    21179499
  • Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, Benoist C, Rudensky AY.Stability of the regulatory T cell lineage in vivo.Science. 2010 Sep 24;329(5999):1667-71.
    20929851
  • Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, Østerås M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, Adams DJ, Mott R, Flint J.Commercially available outbred mice for genome-wide association studies.PLoS Genet. 2010;6(9).
    20838427
  • Nishio J, Feuerer M, Wong J, Mathis D, Benoist C.Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints.J Exp Med. 2010 Aug 30;207(9):1879-89.
    20679403
  • Koh AS, Kingston RE, Benoist C, Mathis D.Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13016-21.
    20615959
  • Feuerer M, Hill JA, Kretschmer K, von Boehmer H, Mathis D, Benoist C.Genomic definition of multiple ex vivo regulatory T cell subphenotypes.Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5919-24.
    20231436
  • Monach PA, Nigrovic PA, Chen M, Hock H, Lee DM, Benoist C, Mathis D.Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.Arthritis Rheum. 2010 Mar;62(3):753-64.
    20191628
  • Abramson J, Giraud M, Benoist C, Mathis D.Aire's partners in the molecular control of immunological tolerance.Cell. 2010 Jan 8;140(1):123-35.
    20085707
  • Mathis D, Benoist C.Levees of immunological tolerance.Nat Immunol. 2010 Jan;11(1):3-6.
    20016503
  • Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U.Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.Arthritis Rheum. 2009 Aug;60(8):2314-24.
    19644878
  • Feuerer M, Hill JA, Mathis D, Benoist C.Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.Nat Immunol. 2009 Jul;10(7):689-95. Review.
    19536194
  • D'Alise AM,Auyeung V,Feuerer M,Nishio J,Fontenot J,Benoist C,Mathis D.The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19857-62.
    19073938
  • Hill JA,Hall JA,Sun CM,Cai Q,Ghyselinck N,Chambon P,Belkaid Y,Mathis D,Benoist C.Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.Immunity. 2008 Nov;29(5):758-70.
    19006694
  • Nigrovic PA,Gray DH,Jones T,Hallgren J,Kuo FC,Chaletzky B,Gurish M,Mathis D,Benoist C,Lee DM.Genetic inversion in mast cell-deficient (W(sh)) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.Am J Pathol. 2008 Dec;173(6):1693-701.
    18988802
  • Koh AS,Kuo AJ,Park SY,Cheung P,Abramson J,Bua D,Carney D,Shoelson SE,Gozani O,Kingston RE,Benoist C,Mathis D.Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83.
    18840680
  • Venanzi ES,Melamed R,Mathis D,Benoist C.The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15860-5.
    18838677
  • Villasenor J,Besse W,Benoist C,Mathis D.Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated.Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15854-9.
    18836079
  • Guerau-de-Arellano M,Mathis D,Benoist C.Transcriptional impact of Aire varies with cell type.Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14011-6.
    18780794
  • Gavanescu I,Benoist C,Mathis D.B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients.Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13009-14.
    18755889
  • Haxhinasto S, Mathis D, Benoist C.The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.J Exp Med. 2008 Mar 17;205(3):565-74.
    18283119
  • Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C.Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.Immunity. 2007 Nov;27(5):786-800.
    18024188
  • Feuerer M, Jiang W, Holler PD, Satpathy A, Campbell C, Bogue M, Mathis D, Benoist C.Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes.Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18181-6.
    17991775
  • Gray D, Abramson J, Benoist C, Mathis D.Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire.J Exp Med. 2007 Oct 29;204(11):2521-8.
    17908938
  • Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D.Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15460-5.
    17881563
  • Wong J, Mathis D, Benoist C.TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets.J Exp Med. 2007 Sep 3;204(9):2039-45.
    17724131
  • Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.J Exp Med. 2007 Aug 6;204(8):1911-22.
    17646407
  • Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C.Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells.J Immunol. 2007 Jun 1;178(11):7032-7041.
    17513752
  • Nguyen LT, Jacobs J, Mathis D, Benoist C.Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.Arthritis Rheum. 2007 Feb;56(2):509-20.
    17265486
  • Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D.Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):570-5.
    17197413
  • Chen Z, Stockton J, Mathis D, Benoist C.Modeling CTLA4-linked autoimmunity with RNA interference in mice.Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16400-5.
    17060611
  • Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A.FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT.Cell. 2006 Jul 28;126(2):375-87.
    16873067
  • Hyatt G, Melamed R, Park R, Seguritan R, Laplace C, Poirot L, Zucchelli S, Obst R, Matos M, Venanzi E, Goldrath A, Nguyen L, Luckey J, Yamagata T, Herman A, Jacobs J, Mathis D, Benoist C.Gene expression microarrays: glimpses of the immunological genome.Nat Immunol. 2006 Jul;7(7):686-91.
    16785882
  • Luckey CJ, Bhattacharya D, Goldrath AW, Weissman IL, Benoist C, Mathis D.Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3304-9.
    16492737
  • Chen Z, Herman AE, Matos M, Mathis D, Benoist C.Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.J Exp Med. 2005 Nov 21;202(10):1387-97.
    16301745
  • Obst R, van Santen HM, Mathis D, Benoist C.Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response.J Exp Med. 2005 May 16;201(10):1555-65.
    15897273