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Lisa A. Cavacini, PhD

Publications

  • Schroeder HW, Cavacini L.Structure and function of immunoglobulins.J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S41-52. Review.
    20176268
  • Pantophlet R,Wrin T,Cavacini LA,Robinson JE,Burton DR.Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity.Virology. 2008 Nov 25;381(2):251-60.
    18822440
  • Duval M, Posner MR, Cavacini LA.A bispecific antibody composed of a nonneutralizing antibody to the gp41 immunodominant region and an anti-CD89 antibody directs broad human immunodeficiency virus destruction by neutrophils.J Virol. 2008 May;82(9):4671-4.
    18272577
  • Bell CH, Pantophlet R, Schiefner A, Cavacini LA, Stanfield RL, Burton DR, Wilson IA.Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization.J Mol Biol. 2008 Jan 25;375(4):969-78.
    18068724
  • Pantophlet R, Aguilar-Sino RO, Wrin T, Cavacini LA, Burton DR.Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis.Virology. 2007 Aug 1;364(2):441-53.
    17418361
  • Miranda LR, Duval M, Doherty H, Seaman MS, Posner MR, Cavacini LA.The Neutralization Properties of a HIV-Specific Antibody Are Markedly Altered by Glycosylation Events Outside the Antigen-Binding Domain.J Immunol. 2007 Jun 1;178(11):7132-8.
    17513762
  • Ahmed AR, Spigelman Z, Cavacini LA, Posner MR.Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin.N Engl J Med. 2006 Oct 26;355(17):1772-9.
    17065638
  • Ferrantelli F, Buckley KA, Rasmussen RA, Chalmers A, Wang T, Li PL, Williams AL, Hofmann-Lehmann R, Montefiori DC, Cavacini LA, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM.Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques.Virology. 2007 Feb 5;358(1):69-78.
    16996554
  • Yeh SW, Cavacini LA, Bhol KC, Lin MS, Kumar M, Duval M, Posner MR, Ahmed AR.Pathogenic human monoclonal antibody against desmoglein 3.Clin Immunol. 2006 Jul;120(1):68-75.
    16635589
  • Kelly-Quintos C, Cavacini LA, Posner MR, Goldmann D, Pier GB.Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine.Infect Immun. 2006 May;74(5):2742-50.
    16622211
  • Wilkinson RA, Piscitelli C, Teintze M, Cavacini LA, Posner MR, Lawrence CM.Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120.J Virol. 2005 Oct;79(20):13060-9.
    16189008
  • Cao W, Cavacini LA, Tillman KC, Posner MR.CD40 function in squamous cell cancer of the head and neck.Oral Oncol. 2005 May;41(5):462-9.
    15878750
  • Cavacini LA, Duval M, Patil A, Wood C, Mayer KH, Ruprecht RM, Posner MR.Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy.J Med Virol. 2005 Jun;76(2):146-52.
    15834877
  • Gokhale AS, Haddad RI, Cavacini LA, Wirth L, Weeks L, Hallar M, Faucher J, Posner MR.Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck.Oral Oncol. 2005 Jan;41(1):70-6.
    15598588
  • Cavacini L, Posner M.Native HIV type 1 virion surface structures: relationships between antibody binding and neutralization or lessons from the viral capture assay.AIDS Res Hum Retroviruses. 2004 Apr;20(4):435-41.
    15157362
  • Ferrantelli F, Kitabwalla M, Rasmussen RA, Cao C, Chou TC, Katinger H, Stiegler G, Cavacini LA, Bai Y, Cotropia J, Ugen KE, Ruprecht RM.Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies-implications for acquired immunodeficiency syndrome vaccine.J Infect Dis. 2004 Jan 1;189(1):71-4.
    14702155
  • Cavacini LA, Kuhrt D, Duval M, Mayer K, Posner MR.Binding and neutralization activity of human IgG1 and IgG3 from serum of HIV-infected individuals.AIDS Res Hum Retroviruses. 2003 Sep;19(9):785-92.
    14585209
  • Liu F, Bergami PL, Duval M, Kuhrt D, Posner M, Cavacini L.Expression and functional activity of isotype and subclass switched human monoclonal antibody reactive with the base of the V3 loop of HIV-1 gp120.AIDS Res Hum Retroviruses. 2003 Jul;19(7):597-607.
    12908937
  • Cavacini L, Duval M, Song L, Sangster R, Xiang SH, Sodroski J, Posner M.Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base.AIDS. 2003 Mar 28;17(5):685-9.
    12646791
  • Kitabwalla M, Ferrantelli F, Wang T, Chalmers A, Katinger H, Stiegler G, Cavacini LA, Chou TC, Ruprecht RM.Primary African HIV clade A and D isolates: effective cross-clade neutralization with a quadruple combination of human monoclonal antibodies raised against clade B.AIDS Res Hum Retroviruses. 2003 Feb;19(2):125-31.
    12639248
  • Ferrantelli F, Hofmann-Lehmann R, Rasmussen RA, Wang T, Xu W, Li PL, Montefiori DC, Cavacini LA, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM.Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques.AIDS. 2003 Feb 14;17(3):301-9.
    12556683
  • Cavacini LA, Duval M, Robinson J, Posner MR.Interactions of human antibodies, epitope exposure, antibody binding and neutralization of primary isolate HIV-1 virions.AIDS. 2002 Dec 6;16(18):2409-17.
    12461414
  • Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Jiang S, Li PL, Baba TW, Montefiori DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Ruprecht RM.Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge.J Med Primatol. 2002 Jun;31(3):109-19.
    12190851
  • Cavacini LA, Duval M, Eder JP, Posner MR.Evidence of determinant spreading in the antibody responses to prostate cell surface antigens in patients immunized with prostate-specific antigen.Clin Cancer Res. 2002 Feb;8(2):368-73.
    11839651
  • Cavacini LA, Duval M, Eder JP, Kufe DW, Schlom J, Posner MR.Evidence of determinant spreading in the antibody responses to prostate cell surface antigens in patients immunized with prostate specific antigen.Clinical Cancer Research. 2002 02 01;8:364-373.
  • Ruprecht RM, Hofmann-Lehmann R, Smith-Franklin BA, Rasmussen RA, Liska V, Vlasak J, Xu W, Baba TW, Chenine AL, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Montefiori DC, McClure HM.Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies.Transfus Clin Biol. 2001 Aug;8(4):350-8.
    11642027
  • Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Smith BA, Baba TW, Liska V, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Posner MR, Cavacini LA, Chou TC, Ruprecht RM.Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission?.J Med Primatol. 2001 Aug;30(4):190-6.
    11555137
  • Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Smith BA, Baba TW, Liska V, Ferrantelli F, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Chou TC, Andersen J, Ruprecht RM.Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge.J Virol. 2001 Aug;75(16):7470-80.
    11462019
  • Xu W, Smith-Franklin BA, Li PL, Wood C, He J, Du Q, Bhat GJ, Kankasa C, Katinger H, Cavacini LA, Posner MR, Burton DR, Chou TC, Ruprecht RM.Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B.J Hum Virol. 2001 Mar-Apr;4(2):55-61.
    11437315
  • Malenbaum SE, Yang D, Cavacini L, Posner M, Robinson J, Cheng-Mayer C.The N-terminal V3 loop glycan modulates the interaction of clade A and B human immunodeficiency virus type 1 envelopes with CD4 and chemokine receptors.J Virol. 2000 Dec;74(23):11008-16.
    11069996
  • Baba TW, Liska V, Hofmann-Lehmann R, Vlasak J, Xu W, Ayehunie S, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Lu Y, Wright JE, Chou TC, Ruprecht RM.Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection.Nat Med. 2000 Feb;6(2):200-6.
    10655110
  • Cavacini LA, Wisnewski A, Peterson JE, Montefiori D, Emes C, Duval M, Kingsbury G, Wang A, Scadden D, Posner MR.A human anti-HIV autoantibody enhances EBV transformation and HIV infection.Clin Immunol. 1999 Dec;93(3):263-73.
    10600338
  • Cavacini LA, Peterson JE, Nappi E, Duval M, Goldstein R, Mayer K, Posner MR.Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individuals.J Virol. 1999 Nov;73(11):9638-41.
    10516076
  • Posner MR, Cavacini LA, Upton MP, Tillman KC, Gornstein ER, Norris CM.Surface membrane-expressed CD40 is present on tumor cells from squamous cell cancer of the head and neck in vitro and in vivo and regulates cell growth in tumor cell lines.Clin Cancer Res. 1999 Aug;5(8):2261-70.
    10473114
  • Cavacini LA, Emes CL, Wisnewski AV, Power J, Lewis G, Montefiori D, Posner MR.Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1271-80.
    9764911
  • Deng B, Banu N, Malloy B, Hass P, Wang JF, Cavacini L, Eaton D, Avraham H.An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis.Blood. 1998 Sep 15;92(6):1981-8.
    9731056
  • Cavacini LA, Samore MH, Gambertoglio J, Jackson B, Duval M, Wisnewski A, Hammer S, Koziel C, Trapnell C, Posner MR.Phase I study of a human monoclonal antibody directed against the CD4-binding site of HIV type 1 glycoprotein 120.AIDS Res Hum Retroviruses. 1998 May 1;14(7):545-50.
    9591708
  • Li A, Katinger H, Posner MR, Cavacini L, Zolla-Pazner S, Gorny MK, Sodroski J, Chou TC, Baba TW, Ruprecht RM.Synergistic neutralization of simian-human immunodeficiency virus SHIV-vpu+ by triple and quadruple combinations of human monoclonal antibodies and high-titer anti-human immunodeficiency virus type 1 immunoglobulins.J Virol. 1998 Apr;72(4):3235-40.
    9525650
  • Franken M, Estabrooks A, Cavacini L, Sherburne B, Wang F, Scadden DT.Epstein-Barr virus-driven gene therapy for EBV-related lymphomas.Nat Med. 1996 Dec;2(12):1379-82.
    8946840
  • Wolfe EJ, Cavacini LA, Samore MH, Posner MR, Kozial C, Spino C, Trapnell CB, Ketter N, Hammer S, Gambertoglio JG.Pharmacokinetics of F105, a human monoclonal antibody, in persons infected with human immunodeficiency virus type 1.Clin Pharmacol Ther. 1996 Jun;59(6):662-7.
    8681491
  • Wisnewski A, Cavacini L, Posner M.Human antibody variable region gene usage in HIV-1 infection.J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jan 1;11(1):31-8.
    8528730
  • Cavacini LA, Emes CL, Power J, Desharnais FD, Duval M, Montefiori D, Posner MR.Influence of heavy chain constant regions on antigen binding and HIV-1 neutralization by a human monoclonal antibody.J Immunol. 1995 Oct 1;155(7):3638-44.
    7561063
  • Khouri YF, McIntosh K, Cavacini L, Posner M, Pagano M, Tuomala R, Marasco WA.Vertical Transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies.J Clin Invest. 1995 Feb;95(2):732-7.
    7860754
  • Cavacini LA, Power J, Emes CL, Mace K, Treacy G, Posner MR.Plasma pharmacokinetics and biological activity of a human immunodeficiency virus type 1 neutralizing human monoclonal antibody, F105, in cynomolgus monkeys.J Immunother Emphasis Tumor Immunol. 1994 May;15(4):251-6.
    8061897
  • Cavacini LA, Emes CL, Power J, Duval M, Posner MR.Effect of antibody valency on interaction with cell-surface expressed HIV-1 and viral neutralization.J Immunol. 1994 Mar 1;152(5):2538-45.
    7510748
  • Thali M, Charles M, Furman C, Cavacini L, Posner M, Robinson J, Sodroski J.Resistance to neutralization by broadly reactive antibodies to the human immunodeficiency virus type 1 gp120 glycoprotein conferred by a gp41 amino acid change.J Virol. 1994 Feb;68(2):674-80.
    7507184
  • Potts BJ, Field KG, Wu Y, Posner M, Cavacini L, White-Scharf M.Synergistic inhibition of HIV-1 by CD4 binding domain reagents and V3-directed monoclonal antibodies.Virology. 1993 Nov;197(1):415-9.
    8212576
  • Cavacini LA, Emes CL, Power J, Underdahl J, Goldstein R, Mayer K, Posner MR.Loss of serum antibodies to a conformational epitope of HIV-1/gp120 identified by a human monoclonal antibody is associated with disease progression.J Acquir Immune Defic Syndr. 1993 Oct;6(10):1093-102.
    7692037
  • Montefiori DC, Graham BS, Zhou J, Zhou J, Bucco RA, Schwartz DH, Cavacini LA, Posner MR.V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120. NIH-NIAID AIDS Vaccine Clinical Trials Net.J Clin Invest. 1993 Aug;92(2):840-7.
    8349820
  • Cavacini LA, Emes CL, Power J, Buchbinder A, Zolla-Pazner S, Posner MR.Human monoclonal antibodies to the V3 loop of HIV-1 gp120 mediate variable and distinct effects on binding and viral neutralization by a human monoclonal antibody to the CD4 binding site.J Acquir Immune Defic Syndr. 1993 Apr;6(4):353-8.
    8455141
  • Posner MR, Cavacini LA, Emes CL, Power J, Byrn R.Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120.J Acquir Immune Defic Syndr. 1993 Jan;6(1):7-14.
    8417177
  • Cavacini LA, Giles-Komar J, Kennel M, Quinn A.Effect of immunosuppressive therapy on cytolytic activity of immunodeficient mice: implications for xenogeneic transplantation.Cell Immunol. 1992 Oct 15;144(2):296-310.
    1394445
  • Marasco WA, Bagley J, Zani C, Posner M, Cavacini L, Haseltine WA, Sodroski J.Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.J Clin Invest. 1992 Oct;90(4):1467-78.
    1401079
  • Cavacini LA, Kennel M, Lally EV, Posner MR, Quinn A.Human immunoglobulin production in immunodeficient mice: enhancement by immunosuppression of host and in vitro activation of human mononuclear cells.Clin Exp Immunol. 1992 Oct;90(1):135-40.
    1395094
  • Posner MR, Elboim HS, Cannon T, Cavacini L, Hideshima T.Functional activity of an HIV-1 neutralizing IgG human monoclonal antibody: ADCC and complement-mediated lysis.AIDS Res Hum Retroviruses. 1992 May;8(5):553-8.
    1381201
  • Cavacini LA, Parke LA, Weidanz WP.Resolution of acute malarial infections by T cell-dependent non-antibody-mediated mechanisms of immunity.Infect Immun. 1990 Sep;58(9):2946-50.
    2387628
  • Weidanz WP, Melancon-Kaplan J, Cavacini LA.Cell-mediated immunity to the asexual blood stages of malarial parasites: animal models.Immunol Lett. 1990 Aug;25(1-3):87-95.
    2126529
  • Cavacini LA, Guidotti M, Parke LA, Melancon-Kaplan J, Weidanz WP.Reassessment of the role of splenic leukocyte oxidative activity and macrophage activation in expression of immunity to malaria.Infect Immun. 1989 Dec;57(12):3677-82.
    2553611
  • Burns JM, Parke LA, Daly TM, Cavacini LA, Weidanz WP, Long CA.A protective monoclonal antibody recognizes a variant-specific epitope in the precursor of the major merozoite surface antigen of the rodent malarial parasite Plasmodium yoelii.J Immunol. 1989 Apr 15;142(8):2835-40.
    2467942
  • Goldring JP, Brake DA, Cavacini LA, Long CA, Weidanz WP.Cloned T cells provide help for malaria-specific polyclonal antibody responses.Eur J Immunol. 1989 Mar;19(3):559-61.
    2468507
  • Weidanz WP, Brake DA, Cavacini LA, Long CA.The protective role of T cells in immunity to malaria.Adv Exp Med Biol. 1988;239:99-111.
    3059780
  • Cavacini LA, Long CA, Weidanz WP.T-cell immunity in murine malaria: adoptive transfer of resistance to Plasmodium chabaudi adami in nude mice with splenic T cells.Infect Immun. 1986 Jun;52(3):637-43.
    3086229