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Zhigang C. Wang, PhD


  • Wang ZC, Birkbak NJ, Culhane AC, Drapkin R, Fatima A, Tian R, Schwede M, Alsop K, Daniels KE, Piao H, Liu J, Etemadmoghadam D, Miron A, Salvesen HB, Mitchell G, Defazio A, Quackenbush J, Berkowitz RS, Iglehart JD, Bowtell DD, , Matulonis UA.Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome.Clin Cancer Res. 2012 Oct 15;18(20):5806-5815.
  • Utermark T, Rao T, Cheng H, Wang Q, Lee SH, Wang ZC, Iglehart JD, Roberts TM, Muller WJ, Zhao JJ.The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Genes Dev. 2012 Jul 15;26(14):1573-86.
  • Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, Onder TT, Wang ZC, Richardson AL, Weinberg RA, Orimo A.Autocrine TGF-{beta} and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20009-14.
  • Tung N, Miron A, Schnitt SJ, Gautam S, Fetten K, Kaplan J, Yassin Y, Buraimoh A, Kim JY, Szasz AM, Tian R, Wang ZC, Collins LC, Brock J, Krag K, Legare RD, Sgroi D, Ryan PD, Silver D, Garber JE, Richardson AL.Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers.Breast Cancer Res. 2010 Nov 16;12(6):R95.
  • Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N, Leong CO, Calogrias D, Buraimoh A, Fatima A, Gelman RS, Ryan PD, Tung NM, De Nicolo A, Ganesan S, Miron A, Colin C, Sgroi DC, Ellisen LW, Winer EP, Garber JE.Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.J Clin Oncol. 2010 Mar 1;28(7):1145-53.
  • Li Y, Zou L, Li Q, Haibe-Kains B, Tian R, Li Y, Desmedt C, Sotiriou C, Szallasi Z, Iglehart JD, Richardson AL, Wang ZC.Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer.Nat Med. 2010 Feb;16(2):214-8.
  • Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC.Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.Cancer Cell. 2009 Aug 4;16(2):115-25.
  • Cheng H, Liu P, Wang ZC, Zou L, Santiago S, Garbitt V, Gjoerup OV, Iglehart JD, Miron A, Richardson AL, Hahn WC, Zhao JJ.SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.Sci Signal. 2009;2(80):ra35.
  • Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szász AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA.A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.Cell. 2009 Jun 12;137(6):1032-46.
  • Wang Y,Carlton VE,Karlin-Neumann G,Sapolsky R,Zhang L,Moorhead M,Wang ZC,Richardson AL,Warren R,Walther A,Bondy M,Sahin A,Krahe R,Tuna M,Thompson PA,Spellman PT,Gray JW,Mills GB,Faham M.High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays.BMC Med Genomics. 2009;2:8.
  • Lu X, Lu X, Wang ZC, Iglehart JD, Zhang X, Richardson AL.Predicting features of breast cancer with gene expression patterns.Breast Cancer Res Treat. 2008 Mar;108(2):191-201.
  • Harezlak J,Wu MC,Wang M,Schwartzman A,Christiani DC,Lin X.Biomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data.J Proteome Res. 2008 Jan;7(1):217-24.
  • Wang ZC, Buraimoh A, Iglehart JD, Richardson AL.Genome-Wide Analysis for Loss of Heterozygosity in Primary and Recurrent Phyllodes Tumor and Fibroadenoma of Breast using Single Nucleotide Polymorphism Arrays.Breast Cancer Res Treat. 2006 Jun;97(3):301-9.
  • Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S.X chromosomal abnormalities in basal-like human breast cancer.Cancer Cell. 2006 Feb;9(2):121-32.
  • Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, Gu H.A role for the scaffolding adapter GAB2 in breast cancer.Nat Med. 2006 Jan;12(1):114-21.
  • Wang ZC, Lin M, Wei LJ, Li C, Miron A, Lodeiro G, Harris L, Ramaswamy S, Tanenbaum DM, Meyerson M, Iglehart JD, Richardson A.Loss of heterozygosity and its correlation with expression profiles in subclasses of invasive breast cancers.Cancer Res. 2004 Jan 1;64(1):64-71.