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Constance L. Cepko, PhD


  • Mizeracka K, Trimarchi JM, Stadler MB, Cepko CL.Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling.Dev Dyn. 2013 Oct;242(10):1147-59.
  • Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL.A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation.Cell. 2013 Aug 15;154(4):928-39.
  • Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV.Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library.PLoS ONE. 2013;8(7):e69314.
  • Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL.Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors.Dev Cell. 2013 Jul 15;26(1):59-72.
  • Mizeracka K, DeMaso CR, Cepko CL.Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate.Development. 2013 Aug;140(15):3188-97.
  • Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL.Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo.Front Neural Circuits. 2013;7:11.
  • Beier K, Cepko C.Viral tracing of genetically defined neural circuitry.Journal Of Visualized Experiments : Jo Ve. 2012(68).
  • Beier KT, Samson ME, Matsuda T, Cepko CL.Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells.Dev Biol. 2011 Mar 17.
  • Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A.An Isoform-Specific SnoN1-FOXO1 Repressor Complex Controls Neuronal Morphogenesis and Positioning in the Mammalian Brain.Neuron. 2011 Mar 10;69(5):930-44.
  • Billings NA, Emerson MM, Cepko CL.Analysis of thyroid response element activity during retinal development.PLoS ONE. 2010;5(10):e13739.
  • Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR.Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein.ACS Chem Biol. 2010 Aug 20;5(8):747-52.
  • Rompani SB, Cepko CL.A common progenitor for retinal astrocytes and oligodendrocytes.J Neurosci. 2010 Apr 7;30(14):4970-80.
  • Kanadia RN, Cepko CL.Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development.Genes Dev. 2010 Feb 1;24(3):229-34.
  • Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P.Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.Nature. 2010 Jan 21;463(7279):374-8.
  • Samson M, Emerson MM, Cepko CL.Robust marking of photoreceptor cells and pinealocytes with several reporters under control of the Crx gene.Dev Dyn. 2009 Dec;238(12):3218-25.
  • Trimarchi JM,Cho SH,Cepko CL.Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.Dev Dyn. 2009 Sep;238(9):2327-9.
  • Jadhav AP,Roesch K,Cepko CL.Development and neurogenic potential of Muller glial cells in the vertebrate retina.Prog Retin Eye Res. 2009 Jul;28(4):249-62. Review.
  • Cherry TJ,Trimarchi JM,Stadler MB,Cepko CL.Development and diversification of retinal amacrine interneurons at single cell resolution.Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9495-500.
  • Dyer MA,Martins R,da Silva Filho M,Muniz JA,Silveira LC,Cepko CL,Finlay BL.Developmental sources of conservation and variation in the evolution of the primate eye.Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8963-8.
  • Chen B,Cepko CL.HDAC4 regulates neuronal survival in normal and diseased retinas.Science. 2009 Jan 9;323(5911):256-9.
  • Punzo C,Kornacker K,Cepko CL.Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa.Nat Neurosci. 2009 Jan;12(1):44-52.
  • Kanadia RN,Clark VE,Punzo C,Trimarchi JM,Cepko CL.Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons.Development. 2008 Dec;135(23):3923-33.
  • Trimarchi JM,Harpavat S,Billings NA,Cepko CL.Thyroid hormone components are expressed in three sequential waves during development of the chick retina.BMC Dev Biol. 2008;8:101.
  • Kim DS,Matsuda T,Cepko CL.A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression.J Neurosci. 2008 Jul 30;28(31):7748-64.
  • Lagali PS, Balya D, Awatramani GB, Munch TA, Kim DS, Busskamp V, Cepko CL, Roska B.Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration.Nat Neurosci. 2008 Jun;11(6):667-75.
  • Roesch K, Jadhav AP, Trimarchi JM, Stadler MB, Roska B, Sun BB, Cepko CL.The transcriptome of retinal Muller glial cells.J Comp Neurol. 2008 May 8;509(2):225-238.
  • Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E.Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.J Neurosci. 2008 May 7;28(19):4878-87.
  • Matsuda T, Cepko CL.Analysis of gene function in the retina.Methods Mol Biol. 2008;423:259-78.
  • Punzo C, Cepko CL.Ultrasound-guided in utero injections allow studies of the development and function of the eye.Dev Dyn. 2008 Apr;237(4):1034-42.
  • Trimarchi JM, Stadler MB, Cepko CL.Individual retinal progenitor cells display extensive heterogeneity of gene expression.PLoS ONE. 2008;3(2):e1588.
  • Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL.Identification of molecular markers of bipolar cells in the murine retina.J Comp Neurol. 2008 Feb 7;507(5):1795-1810.
  • Morrow EM, Chen CM, Cepko CL.Temporal order of bipolar cell genesis in the neural retina.Neural Develop. 2008;3:2.
  • Rompani SB, Cepko CL.Retinal progenitor cells can produce restricted subsets of horizontal cells.Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):192-7.
  • Hsiau TH, Diaconu C, Myers CA, Lee J, Cepko CL, Corbo JC.The cis-regulatory logic of the mammalian photoreceptor transcriptional network.PLoS ONE. 2007;2(7):e643.
  • Corbo JC, Myers CA, Lawrence KA, Jadhav AP, Cepko CL.A typology of photoreceptor gene expression patterns in the mouse.Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12069-74.
  • Chen B, Cepko CL.Requirement of histone deacetylase activity for the expression of critical photoreceptor genes.BMC Dev Biol. 2007;7:78.
  • Viney TJ, Balint K, Hillier D, Siegert S, Boldogkoi Z, Enquist LW, Meister M, Cepko CL, Roska B.Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing.Curr Biol. 2007 Jun 5;17(11):981-8.
  • Trimarchi JM, Stadler MB, Roska B, Billings N, Sun B, Bartch B, Cepko CL.Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling.J Comp Neurol. 2007 Jun 20;502(6):1047-65.
  • Cho SH, Cepko CL.Wnt2b/{beta}-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye.Development. 2006 Aug;133(16):3167-77.
  • Jadhav AP, Mason HA, Cepko CL.Notch 1 inhibits photoreceptor production in the developing mammalian retina.Development. 2006 Mar;133(5):913-23.
  • Corbo JC, Cepko CL.A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.PLoS Genet. 2005 Aug;1(2):e11.
  • Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL.Genomic analysis of mouse retinal development.PLoS Biol. 2004 Sep;2(9):E247.
  • Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA.Rb regulates proliferation and rod photoreceptor development in the mouse retina.Nat Genet. 2004 Apr;36(4):351-60.