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Thomas S. Kupper, MD


  • Litvinov IV, Cordeiro B, Huang Y, Zargham H, Pehr K, Dore MA, Gilbert M, Zhou Y, Kupper TS, Sasseville D.Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients.Clin Cancer Res. 2014 May 21.
  • Watanabe R, Teague JE, Fisher DC, Kupper TS, Clark RA.Alemtuzumab Therapy for Leukemic Cutaneous T-Cell Lymphoma: Diffuse Erythema as a Positive Predictor of Complete Remission.JAMA Dermatol. 2014 Apr 23.
  • Seneschal J, Jiang X, Kupper TS.Langerin+ dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia virus.J Invest Dermatol. 2014 Mar;134(3):686-94.
  • Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, Campbell L, Yawalkar N, Kupper TS, Clark RA.Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.Sci Transl Med. 2014 Jan 15;6(219):219ra8.
  • Li WQ, Han J, Widlund HR, Correll M, Wang YE, Quackenbush J, Mihm MC, Canales AL, Wu S, Golub T, Hoshida Y, Hunter DJ, Murphy G, Kupper TS, Qureshi AA.CXCR4 pathway associated with family history of melanoma.Cancer Causes Control. 2014 Jan;25(1):125-32.
  • Vander Lugt B, Tubo NJ, Nizza ST, Boes M, Malissen B, Fuhlbrigge RC, Kupper TS, Campbell JJ.CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes.J Immunol. 2013 Sep 15;191(6):3119-27.
  • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS.Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.Nat Med. 2012 Aug(8):1248-53.
  • Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, Clark RA.TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma.Clin Cancer Res. 2013 Jul 15;19(14):3755-63.
  • Desimone JA, Guenova E, Carter JB, Chaney KS, Aldridge JR, Noell CM, Dorosario AA, Hansen JL, Kupper TS, Devlin PM.Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma.J Am Acad Dermatol. 2013 Feb 26.
  • Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z.PGC-1 coactivators regulate MITF and the tanning response.Mol Cell. 2013 Jan 10;49(1):145-57.
  • Rodig SJ, Cheng J, Wardzala J, DoRosario A, Scanlon JJ, Laga AC, Martinez-Fernandez A, Barletta JA, Bellizzi AM, Sadasivam S, Holloway DT, Cooper DJ, Kupper TS, Wang LC, DeCaprio JA.Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus.J Clin Invest. 2012 Dec 3;122(12):4645-53.
  • Litvinov IV, Kupper TS, Sasseville D.The role of AHI1 and CDKN1C in cutaneous T-cell lymphoma progression.Exp Dermatol. 2012 Dec;21(12):964-6.
  • Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA.Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells.Mol Cancer Ther. 2012 Nov;11(11):2451-61.
  • Han T, Abdel-Motal UM, Chang DK, Sui J, Muvaffak A, Campbell J, Zhu Q, Kupper TS, Marasco WA.Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma.PLoS ONE. 2012;7(9):e44455.
  • Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA.Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma.J Clin Oncol. 2012 Sep 1;30(25):e233-6.
  • Litvinov IV, Zhou Y, Kupper TS, Sasseville D.Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma.Leuk Lymphoma. 2012 Aug 28.
  • Clark RA, Shackelton JB, Watanabe R, Calarese A, Yamanaka K, Campbell JJ, Teague JE, Kuo HP, Hijnen D, Kupper TS.High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma.Blood. 2011 Feb 10;117(6):1966-76.
  • Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH.VEGFR-1 expressed by malignant melanoma initiating cells is required for tumor growth.Cancer Res. 2011 Jan 11.
  • Richmond J, Tuzova M, Parks A, Adams N, Martin E, Tawa M, Morrison L, Chaney K, Kupper TS, Curiel-Lewandrowski C, Cruikshank W.Interleukin-16 as a Marker of Sézary Syndrome Onset and Stage.J Clin Immunol. 2010 Sep 28.
  • Campbell JJ, Clark RA, Watanabe R, Kupper TS.Sezary syndrome and MF arise from distinct T cell subsets: a biologic rationale for their distinct clinical behaviors.Blood. 2010 Aug 5;116(5):767-71.
  • Yamanaka KI, Fuhlbrigge RC, Mizutani H, Kupper TS.Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma.Arch Dermatol Res. 2010 Aug;302(6):453-9.
  • van Geel NA, Mollet IG, De Schepper S, Tjin EP, Vermaelen K, Clark RA, Kupper TS, Luiten RM, Lambert J.First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi.Pigment Cell Melanoma Res. 2010 Jun;23(3):375-84.
  • Jiang X, Campbell JJ, Kupper TS.Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4.Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7443-8.
  • Litvinov IV, Jones DA, Sasseville D, Kupper TS.Transcriptional Profiles Predict Disease Outcome in Patients with Cutaneous T-Cell Lymphoma.Clin Cancer Res. 2010 Apr 1;16(7):2106-14.
  • Liu L, Zhong Q, Tian T, Dubin K, Athale SK, Kupper TS.Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.Nat Med. 2010 Feb;16(2):224-7.
  • Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA.Imiquimod Enhances IFN-gamma Production and Effector Function of T Cells Infiltrating Human Squamous Cell Carcinomas of the Skin.J Invest Dermatol. 2009 Nov;129(11):2676-85.
  • Bianchi T,Pincus LB,Wurbel MA,Rich BE,Kupper TS,Fuhlbrigge RC,Boes M.Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice.J Immunol. 2009 Apr 15;182(8):4665-74.
  • Clark RA,Huang SJ,Murphy GF,Mollet IG,Hijnen D,Muthukuru M,Schanbacher CF,Edwards V,Miller DM,Kim JE,Lambert J,Kupper TS.Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.J Exp Med. 2008 Sep 29;205(10):2221-34.
  • Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH.Identification of cells initiating human melanomas.Nature. 2008 Jan 17;451(7176):345-9.
  • Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS.Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.J Allergy Clin Immunol. 2008 Jan;121(1):148-157.e3.
  • Shin J, Monti S, Aires DJ, Duvic M, Golub T, Jones DA, Kupper TS.Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome.Blood. 2007 Oct 15;110(8):3015-27.
  • Weishaupt C, Munoz KN, Buzney E, Kupper TS, Fuhlbrigge RC.T-cell distribution and adhesion receptor expression in metastatic melanoma.Clin Cancer Res. 2007 May 1;13(9):2549-56.
  • Clark RA, Kupper TS.IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.Blood. 2007 Jan 1;109(1):194-202.
  • Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS.The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.J Immunol. 2006 Oct 1;177(7):4488-94.
  • Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK, Kupper TS.The vast majority of CLA+ T cells are resident in normal skin.J Immunol. 2006 Apr 1;176(7):4431-9.
  • Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS.Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.Clin Cancer Res. 2006 Jan 15;12(2):376-82.
  • Yamanaka K, Clark R, Rich B, Dowgiert R, Hirahara K, Hurwitz D, Shibata M, Mirchandani N, Jones DA, Goddard DS, Eapen S, Mizutani H, Kupper TS.Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma.Blood. 2006 Mar 15;107(6):2440-5.
  • Yamanaka K, Yawalkar N, Jones DA, Hurwitz D, Ferenczi K, Eapen S, Kupper TS.Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma.Clin Cancer Res. 2005 Aug 15;11(16):5748-55.
  • Adams AE, Zwicker J, Curiel C, Kadin ME, Falchuk KR, Drews R, Kupper TS.Aggressive cutaneous T-cell lymphomas after TNFalpha blockade.J Am Acad Dermatol. 2004 Oct;51(4):660-2.
  • Kupper TS, Fuhlbrigge RC.Immune surveillance in the skin: mechanisms and clinical consequences.Nat Rev Immunol. 2004 Mar;4(3):211-22.
  • Jansing PJ, Chanda R, Gore C, Küpper T.Profiles of occupational exposure in patients with wood dust-induced nasal carcinoma.Int J Occup Med Environ Health. 2003;16(4):329-35.
  • Chong BF, Murphy JE, Kupper TS, Fuhlbrigge RC.E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system.J Immunol. 2004 Feb 1;172(3):1575-81.
  • Hurwitz DJ, Pincus L, Kupper TS.Imiquimod: a topically applied link between innate and acquired immunity.Arch Dermatol. 2003 Oct;139(10):1347-50.
  • Dimitroff CJ, Kupper TS, Sackstein R.Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen.J Clin Invest. 2003 Oct;112(7):1008-18.
  • Robert C, Klein C, Cheng G, Kogan A, Mulligan RC, von Andrian UH, Kupper TS.Gene therapy to target dendritic cells from blood to lymph nodes.Gene Ther. 2003 Aug;10(17):1479-86.
  • Ferenczi K, Yawalkar N, Jones D, Kupper TS.Monitoring the decrease of circulating malignant T cells in cutaneous T-cell lymphoma during photopheresis and interferon therapy.Arch Dermatol. 2003 Jul;139(7):909-13.
  • Yawalkar N, Ferenczi K, Jones DA, Yamanaka K, Suh KY, Sadat S, Kupper TS.Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma.Blood. 2003 Dec 1;102(12):4059-66.
  • Murphy JE, Morales RE, Scott J, Kupper TS.IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis.J Immunol. 2003 Jun 1;170(11):5697-703.
  • Ferenczi K, Fuhlbrigge RC, Pinkus J, Pinkus GS, Kupper TS.Increased CCR4 expression in cutaneous T cell lymphoma.J Invest Dermatol. 2002 Dec;119(6):1405-10.
  • Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R.Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots.J Immunol. 2002 Jun 1;168(11):5645-51.
  • Chauhan D, Auclair D, Robinson EK, Hideshima T, Li G, Podar K, Gupta D, Richardson P, Schlossman RL, Krett N, Chen LB, Munshi NC, Anderson KC.Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.Oncogene. 2002 Feb 21;21(9):1346-58.
  • Pendl GG, Robert C, Steinert M, Thanos R, Eytner R, Borges E, Wild MK, Lowe JB, Fuhlbrigge RC, Kupper TS, Vestweber D, Grabbe S.Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1.Blood. 2002 Feb 1;99(3):946-56.
  • Armerding D, Fuhlbrigge RC, Kieffer JD, Kupper TS.Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity.Int Arch Allergy Immunol. 2001 Sep;126(1):78-90.
  • Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ.BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.Mol Cell. 2001 Sep;8(3):705-11.
  • Kopp T, Kieffer JD, Rot A, Strommer S, Stingl G, Kupper TS.Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40.J Invest Dermatol. 2001 Sep;117(3):618-26.
  • Rich BE, Kupper TS.Cytokines: IL-20 - a new effector in skin inflammation.Curr Biol. 2001 Jul 10;11(13):R531-4.
  • Kieffer JD, Fuhlbrigge RC, Armerding D, Robert C, Ferenczi K, Camphausen RT, Kupper TS.Neutrophils, monocytes, and dendritic cells express the same specialized form of PSGL-1 as do skin-homing memory T cells: cutaneous lymphocyte antigen.Biochem Biophys Res Commun. 2001 Jul 20;285(3):577-87.
  • Cheng SX, Kupper T.A new rexinoid for cutaneous t-cell lymphoma.Arch Dermatol. 2001 May;137(5):649-52.
  • Rossiter H, Beissert S, Mayer C, Schön MP, Wienrich BG, Tschachler E, Kupper TS.Targeted expression of bcl-2 to murine basal epidermal keratinocytes results in paradoxical retardation of ultraviolet- and chemical-induced tumorigenesis.Cancer Res. 2001 May 1;61(9):3619-26.
  • Casellas R, Shih TA, Kleinewietfeld M, Rakonjac J, Nemazee D, Rajewsky K, Nussenzweig MC.Contribution of receptor editing to the antibody repertoire.Science. 2001 Feb 23;291(5508):1541-4.
  • de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW.Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.Immunity. 2001 Jan;14(1):45-55.
  • Kupper TS.T cells, immunosurveillance, and cutaneous immunity.J Dermatol Sci. 2000 Dec;24 Suppl 1:S41-5.
  • Claas C, Stipp CS, Hemler ME.Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts.J Biol Chem. 2001 Mar 16;276(11):7974-84.
  • Müller-Röver S, Rossiter H, Paus R, Handjiski B, Peters EM, Murphy JE, Mecklenburg L, Kupper TS.Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia.Am J Pathol. 2000 Apr;156(4):1395-405.
  • Murphy JE, Robert C, Kupper TS.Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity.J Invest Dermatol. 2000 Mar;114(3):602-8.
  • Frieling UM, Schaumberg DA, Kupper TS, Muntwyler J, Hennekens CH.A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study.Arch Dermatol. 2000 Feb;136(2):179-84.
  • Robert C, Kupper TS.Inflammatory skin diseases, T cells, and immune surveillance.N Engl J Med. 1999 Dec 9;341(24):1817-28.
  • Armerding D, Kupper TS.Functional cutaneous lymphocyte antigen can be induced in essentially all peripheral blood T lymphocytes.Int Arch Allergy Immunol. 1999 Jul;119(3):212-22.
  • Robert C, Fuhlbrigge RC, Kieffer JD, Ayehunie S, Hynes RO, Cheng G, Grabbe S, von Andrian UH, Kupper TS.Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance.J Exp Med. 1999 Feb 15;189(4):627-36.
  • Rauschmayr-Kopp T, Williams IR, Borriello F, Sharpe AH, Kupper TS.Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen.Eur J Immunol. 1998 Dec;28(12):4221-7.
  • Freeman GJ, Cardoso AA, Boussiotis VA, Anumanthan A, Groves RW, Kupper TS, Clark EA, Nadler LM.The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor.J Immunol. 1998 Sep 15;161(6):2708-15.
  • Dubin DB, Hurowitz JC, Brettler D, Bernhard JD, Kadin ME, Wallace JE, Woda B, Pihan G, Kupper TS, Harrist TJ.Adnexotropic T-cell lymphoma presenting with generalized anhidrosis, progressive alopecia, pruritus, and Sjögren's syndrome.J Am Acad Dermatol. 1998 Mar;38(3):493-7.
  • Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS.Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells.Nature. 1997 Oct 30;389(6654):978-81.
  • Williams IR, Rawson EA, Manning L, Karaoli T, Rich BE, Kupper TS.IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells.J Immunol. 1997 Sep 15;159(6):3044-56.
  • Ayehunie S, Garcia-Zepeda EA, Hoxie JA, Horuk R, Kupper TS, Luster AD, Ruprecht RM.Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors.Blood. 1997 Aug 15;90(4):1379-86.
  • Rauschmayr T, Groves RW, Kupper TS.Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation.Proc Natl Acad Sci U S A. 1997 May 27;94(11):5814-9.
  • Rossiter H, Alon R, Kupper TS.Selectins, T-cell rolling and inflammation.Mol Med Today. 1997 May;3(5):214-22.
  • Compton CC, Kupper TS, Nadire KB.HIV-infected Langerhans cells constitute a significant proportion of the epidermal Langerhans cell population throughout the course of HIV disease.J Invest Dermatol. 1996 Dec;107(6):822-6.
  • Groves RW, Rauschmayr T, Nakamura K, Sarkar S, Williams IR, Kupper TS.Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease.J Clin Invest. 1996 Jul 15;98(2):336-44.
  • Williams IR, Ort RJ, Daley D, Manning L, Karaoli T, Barnhill RL, Kupper TS.Constitutive expression of B7-1 (CD80) on mouse keratinocytes does not prevent development of chemically induced skin papillomas and carcinomas.J Immunol. 1996 May 1;156(9):3382-8.
  • Groves RW, Mizutani H, Kieffer JD, Kupper TS.Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis.Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11874-8.
  • Nakamura K, Williams IR, Kupper TS.Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin.J Invest Dermatol. 1995 Nov;105(5):635-43.
  • Ayehunie S, Groves RW, Bruzzese AM, Ruprecht RM, Kupper TS, Langhoff E.Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact.AIDS Res Hum Retroviruses. 1995 Aug;11(8):877-84.
  • Groves RW, Giri J, Sims J, Dower SK, Kupper TS.Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis.J Immunol. 1995 Apr 15;154(8):4065-72.
  • Williams IR, Ort RJ, Kupper TS.Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens.Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12780-4.
  • Alon R, Rossiter H, Wang X, Springer TA, Kupper TS.Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.J Cell Biol. 1994 Dec;127(5):1485-95.
  • Groves RW, Sherman L, Mizutani H, Dower SK, Kupper TS.Detection of interleukin-1 receptors in human epidermis. Induction of the type II receptor after organ culture and in psoriasis.Am J Pathol. 1994 Nov;145(5):1048-56.
  • Mizutani H, Roswit W, Hemperly J, Lawley T, Compton C, Swerlick R, Kupper TS.Human dermal microvascular endothelial cells express the 140-kD isoform of neural cell adhesion molecule.Biochem Biophys Res Commun. 1994 Aug 30;203(1):686-93.
  • Xu H, Gonzalo JA, St Pierre Y, Williams IR, Kupper TS, Cotran RS, Springer TA, Gutierrez-Ramos JC.Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.J Exp Med. 1994 Jul 1;180(1):95-109.
  • Rossiter H, van Reijsen F, Mudde GC, Kalthoff F, Bruijnzeel-Koomen CA, Picker LJ, Kupper TS.Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding.Eur J Immunol. 1994 Jan;24(1):205-10.
  • Ferguson TA, Kupper TS.Antigen-independent processes in antigen-specific immunity. A role for alpha 4 integrin.J Immunol. 1993 Feb 15;150(4):1172-82.
  • Chan BM, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME.Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains.Cell. 1992 Mar 20;68(6):1051-60.
  • Schiro JA, Chan BM, Roswit WT, Kassner PD, Pentland AP, Hemler ME, Eisen AZ, Kupper TS.Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells.Cell. 1991 Oct 18;67(2):403-10.
  • Mizutani H, Schechter N, Lazarus G, Black RA, Kupper TS.Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.J Exp Med. 1991 Oct 1;174(4):821-5.
  • Ferguson TA, Mizutani H, Kupper TS.Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):8072-6.
  • Mizutani H, Black R, Kupper TS.Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.J Clin Invest. 1991 Mar;87(3):1066-71.
  • Kupper TS.Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations.J Clin Invest. 1990 Dec;86(6):1783-9.
  • Mizutani H, May LT, Sehgal PB, Kupper TS.Synergistic interactions of IL-1 and IL-6 in T cell activation. Mitogen but not antigen receptor-induced proliferation of a cloned T helper cell line is enhanced by exogenous IL-6.J Immunol. 1989 Aug 1;143(3):896-901.
  • Kupper TS.Production of cytokines by epithelial tissues. A new model for cutaneous inflammation.Am J Dermatopathol. 1989 Feb;11(1):69-73.
  • Kupper TS, Lee F, Birchall N, Clark S, Dower S.Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis.J Clin Invest. 1988 Nov;82(5):1787-92.