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Bruce M. Spiegelman, PhD

Publications

  • Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM.Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.Nature. 2014 Sep 4;513(7516):100-4.
    25043053
  • Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM.Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis.Cell. 2014 Jun 5;157(6):1279-91.
    24906147
  • Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ, Rosen ED, Spiegelman BM.A Smooth Muscle-Like Origin for Beige Adipocytes.Cell Metab. 2014 Apr 2.
    24709624
  • Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM.Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.Cell. 2014 Jan 16;156(1-2):304-16.
    24439384
  • Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM.Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.Cell Metab. 2013 Nov 5;18(5):649-59.
    24120943
  • Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM.Fat cells directly sense temperature to activate thermogenesis.Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12480-5.
    23818608
  • Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P.PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.Cancer Cell. 2013 Mar 18;23(3):287-301.
    23416000
  • Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM.TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis.Cell. 2012 Sep 28;151(1):96-110.
    23021218
  • Handschin C, Spiegelman BM.PGC-1 Coactivators and the Regulation of Skeletal Muscle Fiber-Type Determination.Cell Metab. 2011 Apr 6;13(4):351.
    21459315
  • Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR.Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.Development. 2010 Oct;137(20):3489-99.
    20843861
  • Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM.Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.Nature. 2010 Jul 22;466(7305):451-6.
    20651683
  • Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T.NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12317-22.
    20566846
  • Kajimura S, Seale P, Spiegelman BM.Transcriptional control of brown fat development.Cell Metab. 2010 Apr 7;11(4):257-62. Review.
    20374957
  • Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM.Transcriptional control of preadipocyte determination by Zfp423.Nature. 2010 Mar 25;464(7288):619-23.
    20200519
  • Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM.PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22510-5.
    20018698
  • Handschin C, Summermatter S, LeBrasseur NK, Lin J, Spiegelman BM.For a pragmatic approach to exercise studies.J Appl Physiol. 2010 Jan;108(1):223-3; author reply 226.
    20066760
  • Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT.Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging.Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20405-10.
    19918075
  • Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM.Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.Nature. 2009 Aug 27;460(7259):1154-8.
    19641492
  • Kleiner S,Nguyen-Tran V,Bare O,Huang X,Spiegelman BM,Wu Z.PPARdelta agonism activates fatty acid oxidation via PGC-1alpha but does not increase mitochondrial gene expression and function.J Biol Chem. 2009 Jul 10;284(28):18624-33.
    19435887
  • Estall JL,Kahn M,Cooper MP,Fisher FM,Wu MK,Laznik D,Qu L,Cohen DE,Shulman GI,Spiegelman BM.Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic PGC-1{alpha} expression.Diabetes. 2009 Jul;58(7):1499-508.
    19366863
  • Seale P,Kajimura S,Spiegelman BM.Transcriptional control of brown adipocyte development and physiological function--of mice and men.Genes Dev. 2009 Apr 1;23(7):788-97. Review.
    19339685
  • Choi CS,Befroy DE,Codella R,Kim S,Reznick RM,Hwang YJ,Liu ZX,Lee HY,Distefano A,Samuel VT,Zhang D,Cline GW,Handschin C,Lin J,Petersen KF,Spiegelman BM,Shulman GI.Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31.
    19066218
  • Girnun GD,Chen L,Silvaggi J,Drapkin R,Chirieac LR,Padera RF,Upadhyay R,Vafai SB,Weissleder R,Mahmood U,Naseri E,Buckley S,Li D,Force J,McNamara K,Demetri G,Spiegelman BM,Wong KK.Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.Clin Cancer Res. 2008 Oct 15;14(20):6478-86.
    18927287
  • Wenz T,Diaz F,Spiegelman BM,Moraes CT.Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype.Cell Metab. 2008 Sep;8(3):249-56.
    18762025
  • Cooper MP,Uldry M,Kajimura S,Arany Z,Spiegelman BM.Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.J Biol Chem. 2008 Nov 14;283(46):31960-7.
    18728005
  • Seale P,Bjork B,Yang W,Kajimura S,Chin S,Kuang S,Scime A,Devarakonda S,Conroe HM,Erdjument-Bromage H,Tempst P,Rudnicki MA,Beier DR,Spiegelman BM.PRDM16 controls a brown fat/skeletal muscle switch.Nature. 2008 Aug 21;454(7207):961-7.
    18719582
  • Handschin C,Spiegelman BM.The role of exercise and PGC1alpha in inflammation and chronic disease.Nature. 2008 Jul 24;454(7203):463-9. Review.
    18650917
  • Walkey CJ,Spiegelman BM.A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.J Biol Chem. 2008 Sep 5;283(36):24290-4.
    18622018
  • Kajimura S,Seale P,Tomaru T,Erdjument-Bromage H,Cooper MP,Ruas JL,Chin S,Tempst P,Lazar MA,Spiegelman BM.Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.Genes Dev. 2008 May 15;22(10):1397-409.
    18483224
  • Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM.Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4721-6.
    18347329
  • Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM.HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.Nature. 2008 Feb 21;451(7181):1008-12.
    18288196
  • Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, Stevenson SC, Rangwala SM.Muscle-specific expression of PPAR{gamma} coactivator-1{alpha} improves exercise performance and increases peak oxygen uptake.J Appl Physiol. 2008 May;104(5):1304-12.
    18239076
  • Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.J Clin Invest. 2007 Nov;117(11):3463-74.
    17932564
  • Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM.Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.J Biol Chem. 2007 Oct 12;282(41):30014-21.
    17702743
  • Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM.Transcriptional control of brown fat determination by PRDM16.Cell Metab. 2007 Jul;6(1):38-54.
    17618855
  • Jger S, Handschin C, St-Pierre J, Spiegelman BM.AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22.
    17609368
  • Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM.Synergy between PPARgamma Ligands and Platinum-Based Drugs in Cancer.Cancer Cell. 2007 May;11(5):395-406.
    17482130
  • Rohas LM, St-Pierre J, Uldry M, Jger S, Handschin C, Spiegelman BM.A fundamental system of cellular energy homeostasis regulated by PGC-1alpha.Proc Natl Acad Sci U S A. 2007 May 8;104(19):7933-8.
    17470778
  • Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM.PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.Genes Dev. 2007 Apr 1;21(7):770-83.
    17403779
  • Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM.The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.Cell Metab. 2007 Jan;5(1):35-46.
    17189205
  • Rosen ED, Spiegelman BM.Adipocytes as regulators of energy balance and glucose homeostasis.Nature. 2006 Dec 14;444(7121):847-53. Review.
    17167472
  • St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM.Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.Cell. 2006 Oct 20;127(2):397-408.
    17055439
  • Kim R, Arihiro K, Emi M, Tanabe K, Osaki A.Potential role of HER-2; in primary breast tumor with bone metastasis.Oncol Rep. 2006 Jun;15(6):1477-84.
    16685382
  • Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM.Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.Cell Metab. 2006 May;3(5):333-41.
    16679291
  • Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM.Partnership of PGC-1{alpha} and HNF4{alpha} in the Regulation of Lipoprotein Metabolism.J Biol Chem. 2006 May 26;281(21):14683-90.
    16574644
  • Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD.The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes.Cell Metab. 2005 Oct;2(4):227-38.
    16213225
  • Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM.Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.Cell. 2005 Aug 26;122(4):505-15.
    16122419
  • Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB.TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.Science. 2005 Aug 12;309(5737):1074-8.
    16099986
  • Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM.Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms.Cell Metab. 2005 Feb;1(2):93-106.
    16054051
  • Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM.Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.Cell Metab. 2005 Apr;1(4):259-71.
    16054070
  • Lin J, Handschin C, Spiegelman BM.Metabolic control through the PGC-1 family of transcription coactivators.Cell Metab. 2005 Jun;1(6):361-70.
    16054085
  • Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P.Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.Nature. 2005 Mar 3;434(7029):113-8.
    15744310
  • Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Kia X, Shivdasani RA, Spiegelman BM.Hic-5 regulates an epithelial program mediated by PPARgamma.Genes Dev. 2005 Feb 1;19(3):362-75.
    15687259
  • Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM.Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.Cell. 2005 Jan 28;120(2):261-73.
    15680331
  • Smith MR, Manola J, Kaufman DS, George D, Oh WK, Mueller E, Slovin S, Spiegelman B, Small E, Kantoff PW.Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy.Cancer. 2004 Oct 1;101(7):1569-74.
    15468186
  • Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.Cell. 2004 Oct 1;119(1):121-35.
    15454086
  • Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM.Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5.
    15100410
  • Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S.p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.Mol Cell Biol. 2004 Apr;24(7):3057-67.
    15024092
  • Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM.Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.Genes Dev. 2004 Feb 1;18(3):278-89.
    14744933
  • Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG.Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.Mol Cell. 2003 Nov;12(5):1137-49.
    14636573
  • Burstein HJ, Demetri GD, Mueller E, Sarraf P, Spiegelman BM, Winer EP.Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.Breast Cancer Res Treat. 2003 Jun;79(3):391-7.
    12846423
  • Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS.A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.Cancer J. 2002 Sep-Oct;8(5):395-9.
    12416897
  • Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, Kucherlapati R, Gonzalez FJ, Spiegelman BM.APC-dependent suppression of colon carcinogenesis by PPARgamma.Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13771-6.
    12370429
  • Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM.Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms.J Biol Chem. 2002 Nov 1;277(44):41925-30.
    12200443
  • Rich-Edwards JW, Spiegelman D, Garland M, Hertzmark E, Hunter DJ, Colditz GA, Willett WC, Wand H, Manson JE.Physical activity, body mass index, and ovulatory disorder infertility.Epidemiology. 2002 Mar;13(2):184-90.
    11880759
  • Coley JL, Msamanga GI, Fawzi MC, Kaaya S, Hertzmark E, Kapiga S, Spiegelman D, Hunter D, Fawzi WW.The association between maternal HIV-1 infection and pregnancy outcomes in Dar es Salaam, Tanzania.BJOG. 2001 Nov;108(11):1125-33.
    11762650
  • Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM.Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.J Biol Chem. 2002 Jan 18;277(3):1645-8.
    11733490
  • Field AE, Wing RR, Manson JE, Spiegelman DL, Willett WC.Relationship of a large weight loss to long-term weight change among young and middle-aged US women.Int J Obes Relat Metab Disord. 2001 Aug;25(8):1113-21.
    11477495
  • Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW.The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.Nat Med. 2001 Jan;7(1):41-7.
    11135614
  • Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman DS, Oh W, Demetri G, Figg WD, Zhou XP, Eng C, Spiegelman BM, Kantoff PW.Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10990-5.
    10984506
  • Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM.Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.Mol Cell. 2000 Aug;6(2):307-16.
    10983978
  • Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA.PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].Science. 2000 Aug 25;289(5483):1357-60.
    10958784
  • Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM.Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.Mol Cell Biol. 2000 Jul;20(14):5343-9.
    10866690
  • Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, Spiegelman BM.A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation.J Biol Chem. 2000 Jan 21;275(3):1873-7.
    10636887
  • Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM.PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.Mol Cell. 1999 Oct;4(4):611-7.
    10549292
  • Sarraf P, Mueller E, Smith WM, Wright HM, Kum JB, Aaltonen LA, de la Chapelle A, Spiegelman BM, Eng C.Loss-of-function mutations in PPAR gamma associated with human colon cancer.Mol Cell. 1999 Jun;3(6):799-804.
    10394368
  • Castillo G, Brun RP, Rosenfield JK, Hauser S, Park CW, Troy AE, Wright ME, Spiegelman BM.An adipogenic cofactor bound by the differentiation domain of PPARgamma.EMBO J. 1999 Jul 1;18(13):3676-87.
    10393183
  • Demetri GD, Fletcher CD, Mueller E, Sarraf P, Naujoks R, Campbell N, Spiegelman BM, Singer S.Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6.
    10097144
  • Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S, Spiegelman BM.Terminal differentiation of human breast cancer through PPAR gamma.Mol Cell. 1998 Feb;1(3):465-70.
    9660931
  • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM.A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.Cell. 1998 Mar 20;92(6):829-39.
    9529258
  • Spiegelman BM.Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.Eur J Med Res. 1997 Nov 28;2(11):457-64.
    9385114
  • Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM.Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.J Clin Invest. 1998 Jan 1;101(1):1-9.
    9421459
  • Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM.Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):237-41.
    8990192
  • Spiegelman BM, Flier JS.Adipogenesis and obesity: rounding out the big picture.Cell. 1996 Nov 1;87(3):377-89.
    8898192
  • Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM.Differential activation of adipogenesis by multiple PPAR isoforms.Genes Dev. 1996 Apr 15;10(8):974-84.
    8608944
  • Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM.15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.Cell. 1995 Dec 1;83(5):803-12.
    8521497
  • Tontonoz P, Hu E, Spiegelman BM.Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.Cell. 1994 Dec 30;79(7):1147-56.
    8001151