Andrew T. Chan, MD, MPH

Publications

• Lee JE, Li H, Chan AT, Hollis BW, Lee IM, Stampfer MJ, Wu K, Giovannucci E, Ma J.Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies.Cancer Prev Res (Phila Pa). 2011 Mar
  21430073
• Baba Y, Nosho K, Shima K, Hayashi M, Meyerhardt JA, Chan AT, Giovannucci E, Fuchs CS, Ogino S.Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.Cancer. 2011 Apr 1;117(7):1399-408.
  21425139
• Khalili H, Wolpin BM, Huang ES, Giovannucci E, Kraft P, Fuchs CS, Chan AT.ABO Blood Group and Risk of Colorectal Cancer.Cancer Epidemiol Biomarkers Prev. 2011 Mar 17.
  21415359
• Chan AT, Ogino S, Giovannucci EL, Fuchs CS.Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs.Gastroenterology. 2011 Mar;140(3):799-808.e2.
  21115010
• Ogino S, Chan AT, Fuchs CS, Giovannucci E.Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field.Gut. 2011 Mar;60(3):397-411. Review.
  21036793
• Bao Y, Nimptsch K, Meyerhardt J, Chan AT, Ng K, Michaud DS, Brand-Miller JC, Willett WC, Giovannucci E, Fuchs CS.Dietary insulin load, dietary insulin index, and colorectal cancer.Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3020-6.
  20924099
• Baba Y, Nosho K, Shima K, Hayashi M, Meyerhardt JA, Chan AT, Giovannucci E, Fuchs CS, Ogino S.Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.Cancer. 2010 Nov 8.
  21061337
• Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri A, Shue D, Kucherlapati R, Fuchs CS, Ogino S.Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia.Cancer Epidemiol
  20833970
• Baba Y, Nosho K, Shima K, Meyerhardt JA, Chan AT, Engelman JA, Cantley LC, Loda M, Giovannucci E, Fuchs CS, Ogino S.Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.Br J Cancer. 2010 S
  20808308
• Giovannucci E, Chan AT.Role of vitamin and mineral supplementation and aspirin use in cancer survivors.J Clin Oncol. 2010 Sep 10;28(26):4081-5. Review.
  20697066
• Das KK, Nishino HT, Chan AT.Treatment-associated acute myeloid leukemia in a patient with Crohn's disease on 6-mercaptopurine.Inflamm Bowel Dis. 2010 Sep;16(9):1454-6.
  20128002
• Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS, Ogino S.HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.Am J Pathol. 2010 May;176(5):2292-301.
  20363910
• Chan AT.COX-2 expression in adenoma: an imperfect marker for chemoprevention.Gut. 2010 May;59(5):568-9.
  20427388
• Chan AT, Giovannucci EL.Primary prevention of colorectal cancer.Gastroenterology. 2010 Jun;138(6):2029-2043.e10. Review.
  20420944
• Baba Y, Nosho K, Shima K, Goessling W, Chan AT, Ng K, Chan JA, Giovannucci EL, Fuchs CS, Ogino S.PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.Cancer Epidemiol Biom
  20200425
• Meyerhardt JA, Giovannucci EL, Ogino S, Kirkner GJ, Chan AT, Willett W, Fuchs CS.Physical activity and male colorectal cancer survival.Arch Intern Med. 2009 Dec 14;169(22):2102-8.
  20008694
• Jacobson BC,Chan AT,Giovannucci EL,Fuchs CS.Body Mass Index and Barrett's Oesophagus in Women.Gut. 2009 Nov;58(11):1460-6.
  19336423
• Meyerhardt JA, Ogino S, Kirkner GJ, Chan AT, Wolpin B, Ng K, Nosho K, Shima K, Giovannucci EL, Loda M, Fuchs CS.Interaction of molecular markers and physical activity on mortality in patients with colon cancer.Clin Cancer Res. 2009 Sep 15;15(18):5931-6.
  19723652
• Chan AT, Ogino S, Fuchs CS.Aspirin use and survival after diagnosis of colorectal cancer.JAMA. 2009 Aug 12;302(6):649-58.
  19671906
• Ogino S, Nosho K, Baba Y, Kure S, Shima K, Irahara N, Toyoda S, Chen L, Kirkner GJ, Wolpin BM, Chan AT, Giovannucci EL, Fuchs CS.A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis.Am J Gastroenterol. 2009 Aug;104(8):204
  19513025
• Chan AT,Zauber AG,Hsu M,Breazna A,Hunter DJ,Rosenstein RB,Eagle CJ,Hawk ET,Bertagnolli MM.Cytochrome P450 2C9 Variants Influence Response to Celecoxib for Prevention of Colorectal Adenoma.Gastroenterology. 2009 Jun;136(7):2127-2136.e1.
  19233181
• Ma BB, Mo FK, Chan AT, Hui EP, Leung SF, Lo YM, Yau YY, King AD.The prognostic significance of tumor vascular invasion and its association with plasma Epstein-Barr virus DNA, tumor volume and metabolic activity in locoregionally advanced nasopharyngeal ca
  18396444
• Wolpin BM,Chan AT,Hartge P,Chanock SJ,Kraft P,Hunter DJ,Giovannucci EL,Fuchs CS.ABO blood group and the risk of pancreatic cancer.Journal of the National Cancer Institute. 2009 Mar 18;101(6):424-31.
  19276450
• Ogino S,Nosho K,Kirkner GJ,Shima K,Irahara N,Kure S,Chan AT,Engelman JA,Kraft P,Cantley LC,Giovannucci EL,Fuchs CS.PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.J Clin Oncol. 2009 Mar 20;27(9):1477-
  19237633
• Ogino S,Kirkner GJ,Nosho K,Irahara N,Kure S,Shima K,Hazra A,Chan AT,Dehari R,Giovannucci EL,Fuchs CS.Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer.Clin Cancer Res. 2008 Dec 15;14(24):8221-7.
  19088039
• Wolpin BM,Meyerhardt JA,Chan AT,Ng K,Chan JA,Wu K,Pollak MN,Giovannucci EL,Fuchs CS.Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer.J Clin Oncol. 2009 Jan 10;27(2):176-85.
  19064975
• Ogino S,Nosho K,Kirkner GJ,Kawasaki T,Chan AT,Schernhammer ES,Giovannucci EL,Fuchs CS.A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer.Journal of the National Cancer Institute. 2008 Dec 3;100(23):1734-8.
  19033568
• Nosho K, Kawasaki T, Chan AT, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, Ogino S.Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype.Histopathology. 2008 Nov;53(5):588-98.
  18983468
• Ogino S,Nosho K,Meyerhardt JA,Kirkner GJ,Chan AT,Kawasaki T,Giovannucci EL,Loda M,Fuchs CS.Cohort study of fatty acid synthase expression and patient survival in colon cancer.J Clin Oncol. 2008 Dec 10;26(35):5713-20.
  18955444
• Lee KY, Geng H, Ng KM, Yu J, van Hasselt A, Cao Y, Zeng YX, Wong AH, Wang X, Ying J, Srivastava G, Lung ML, Wang LD, Kwok TT, Levi BZ, Chan AT, Sung JJ, Tao Q.Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interf
  18469857
• Berndt SI,Potter JD,Hazra A,Yeager M,Thomas G,Makar KW,Welch R,Cross AJ,Huang WY,Schoen RE,Giovannucci E,Chan AT,Chanock SJ,Peters U,Hunter DJ,Hayes RB.Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.Hum Mol Genet. 20
  18535017
• Hazra A,Fuchs CS,Chan AT,Giovannucci EL,Hunter DJ.Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk.Cancer Causes Control. 2008 Nov;19(9):975-80.
  18478343
• Chan AT, Felip E.Nasopharyngeal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up.Ann Oncol. 2008 May;19 Suppl 2:ii81-2.
  18456780
• Chan AL, Juarez MM, Allen RP, Albertson TE.Do airway metallic stents for benign lesions confer too costly a benefit?.BMC Pulm Med. 2008 Apr 18;8(1):7.
  18423035
• Wong CS, Cheung MT, Ma BB, Pun Hui E, Chan AC, Chan CK, Lee KC, Cheuk W, Lam MY, Wong MC, Chan CM, Chan JK, Chan AT.Isolated Tumor Cells and Circulating CK20 mRNA in pN0 Colorectal Cancer Patients.Int J Surg Pathol. 2008 Apr;16(2):119-26.
  18387990
• Chan CM, Wong SC, Lam MY, Hui EP, Chan JK, Lo ES, Cheuk W, Wong MC, Tsao SW, Chan AT.Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma.Arch Path
  18384219
• King AD, Ma BB, Yau YY, Zee B, Leung SF, Wong JK, Kam MK, Ahuja AT, Chan AT.The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis.Br J Radiol. 2008 Apr;81(964):291-8.
  18344274
• Thomas MB, O'Beirne JP, Furuse J, Chan AT, Abou-Alfa G, Johnson P.Systemic therapy for hepatocellular carcinoma: cytotoxic chemotherapy, targeted therapy and immunotherapy.Ann Surg Oncol. 2008 Apr;15(4):1008-14. Review.
  18236117
• Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S.Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serra
  18230181
• Haigh TA, Lin X, Jia H, Hui EP, Chan AT, Rickinson AB, Taylor GS.EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines.J Immunol. 2008 Feb 1;180(3):1643-54.
  18209060
• Yu SC, Hui EP, Wong J, Wong H, Mo F, Ho SS, Wong YY, Yeo W, Lai PB, Chan AT, Mok TS.Transarterial ethanol ablation of hepatocellular carcinoma with lipiodol ethanol mixture: phase II study.J Vasc Interv Radiol. 2008 Jan;19(1):95-103.
  18192473
• Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Wu K, Fuchs CS.Aspirin dose and duration of use and risk of colorectal cancer in men.Gastroenterology. 2008 Jan;134(1):21-8.
  18005960
• Feskanich D, Bain C, Chan AT, Pandeya N, Speizer FE, Colditz GA.Aspirin and lung cancer risk in a cohort study of women: dosage, duration and latency.Br J Cancer. 2007 Nov 5;97(9):1295-9.
  17895894
• Cho E, Willett WC, Colditz GA, Fuchs CS, Wu K, Chan AT, Zeisel SH, Giovannucci EL.Dietary choline and betaine and the risk of distal colorectal adenoma in women.J Natl Cancer Inst. 2007 Aug 15;99(16):1224-31.
  17686825
• Chan AT, Ogino S, Fuchs CS.Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2.N Engl J Med. 2007 May 24;356(21):2131-2142.
  17522398
• Chan AT.Can aspirin prevent colorectal cancer?.Lancet. 2007 May 12;369(9573):1577-8.
  17499581
• Chan AT, Manson JE, Feskanich D, Stampfer MJ, Colditz GA, Fuchs CS.Long-term aspirin use and mortality in women.Arch Intern Med. 2007 Mar 26;167(6):562-72.
  17389287
• Chan JA, Meyerhardt JA, Chan AT, Giovannucci EL, Colditz GA, Fuchs CS.Hormone replacement therapy and survival after colorectal cancer diagnosis.J Clin Oncol. 2006 Dec 20;24(36):5680-6.
  17179103
• Meyerhardt JA, Giovannucci EL, Holmes MD, Chan AT, Chan JA, Colditz GA, Fuchs CS.Physical activity and survival after colorectal cancer diagnosis.J Clin Oncol. 2006 Aug 1;24(22):3527-34.
  16822844
• Hur C, Chan AT, Tramontano AC, Gazelle GS.Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs.Ann Pharmacother. 2006 Jun;40(6):1052-63.
  16720709
• Michels KB, Giovannucci E, Chan AT, Singhania R, Fuchs CS, Willett WC.Fruit and vegetable consumption and colorectal adenomas in the Nurses' Health Study.Cancer Res. 2006 Apr 1;66(7):3942-53.
  16585224
• Chan AT, Manson JE, Albert CM, Chae CU, Rexrode KM, Curhan GC, Rimm EB, Willett WC, Fuchs CS.Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events.Circulation. 2006 Mar 28;113(12):1578-87.
  16534006
• Schernhammer ES, Tranah GJ, Giovannucci E, Chan AT, Ma J, Colditz GA, Hunter DJ, Willett WC, Fuchs CS.Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma.Br J Cancer. 2006 Mar 27;94(6):928-34.
  16495921
• Chan AT, Fuchs CS.Do cyclo-oxygenase 2 inhibitors increase the risk of cardiovascular events?.Nat Clin Pract Oncol. 2005 Sep;2(9):434-5.
  16265007
• Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Curhan GC, Fuchs CS.Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer.JAMA. 2005 Aug 24;294(8):914-23.
  16118381
• Chan AT, Ma J, Tranah GJ, Giovannucci EL, Rifai N, Hunter DJ, Fuchs CS.Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women.J Natl Cancer Inst. 2005 Jun 15;97(12):917-26.
  15956653
• Tranah GJ, Chan AT, Giovannucci E, Ma J, Fuchs C, Hunter DJ.Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study.Mol Carcinog. 2005 Sep;44(1):2
  15924351
• Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS.Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma.J Natl Cancer Inst. 2005 Mar 16;97(6):457-60.
  15770010
• Chan AT, Tranah GJ, Giovannucci EL, Willett WC, Hunter DJ, Fuchs CS.Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer.Int J Cancer. 2005 Jul 1;115(4):648-52.
  15700302
• Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS.A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma.Clin Gastroenterol Hepatol. 2004 Aug;2(8):704-12.
  15290664
• Chan AT, Giovannucci EL, Schernhammer ES, Colditz GA, Hunter DJ, Willett WC, Fuchs CS.A prospective study of aspirin use and the risk for colorectal adenoma.Ann Intern Med. 2004 Feb 3;140(3):157-66.
  14757613
• Schernhammer ES, Kang JH, Chan AT, Michaud DS, Skinner HG, Giovannucci E, Colditz GA, Fuchs CS.A prospective study of aspirin use and the risk of pancreatic cancer in women.J Natl Cancer Inst. 2004 Jan 7;96(1):22-8.
  14709735
• Chan AT.Aspirin, non-steroidal anti-inflammatory drugs and colorectal neoplasia: future challenges in chemoprevention.Cancer Causes Control. 2003 Jun;14(5):413-8.
  12946035
• Hylek EM, Regan S, Henault LE, Gardner M, Chan AT, Singer DE, Barry MJ.Challenges to the effective use of unfractionated heparin in the hospitalized management of acute thrombosis.Arch Intern Med. 2003 Mar 10;163(5):621-7.
  12622610
• Wong IH, Yeo W, Chan AT, Johnson PJ.Quantitative correlation of cytokeratin 19 mRNA level in peripheral blood with disease stage and metastasis in breast cancer patients: potential prognostic implications.Int J Oncol. 2001 Mar;18(3):633-8.
  11179498
• Wong IH, Yeo W, Chan AT, Johnson PJ.Quantitative relationship of the circulating tumor burden assessed by reverse transcription-polymerase chain reaction for cytokeratin 19 mRNA in peripheral blood of colorectal cancer patients with Dukes' stage, seru
  11121864
• Wong IH, Chan AT, Johnson PJ.Molecular analysis of circulating tumor cells in peripheral blood from patients with germ cell tumor: a quantitative approach.Int J Mol Med. 2000 Oct;6(4):491-4.
  10998444
• Wong IH, Chan AT, Johnson PJ.Quantitative analysis of circulating tumor cells in peripheral blood of osteosarcoma patients using osteoblast-specific messenger RNA markers: a pilot study.Clin Cancer Res. 2000 Jun;6(6):2183-8.
  10873067
• Chan AT, Atiemo A, Diran LK, Licholai GP, McLaren Black P, Creager MA, Goldhaber SZ.Venous thromboembolism occurs frequently in patients undergoing brain tumor surgery despite prophylaxis.J Thromb Thrombolysis. 1999 Aug;8(2):139-42.
  10436144
• Su HC, Orange JS, Fast LD, Chan AT, Simpson SJ, Terhorst C, Biron CA.IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice.J Immunol. 1994 Dec 15;153(12):5674-81.
  7989765