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Joanne Chan, PhD


  • Kawasaki J, Aegerter S, Fevurly RD, Mammoto A, Mammoto T, Sahin M, Mably JD, Fishman SJ, Chan J.RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity.J Clin Invest. 2014 Jun 2;124(6):2774-84.
  • Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL.Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Proc Natl Acad Sci U S A. 2013 May 14;110(20):8188-93.
  • Chan JA, Mayer RJ, Jackson N, Malinowski P, Regan E, Kulke MH.Phase I study of sorafenib in combination with everolimus (RAD001) in patients with advanced neuroendocrine tumors.Cancer Chemother Pharmacol. 2013 Mar 9.
  • Jia D, Hasso SM, Chan J, Filingeri D, D'Amore PA, Rice L, Pampo C, Siemann DW, Zurakowski D, Rodig SJ, Moses MA.Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo.Blood. 2013 Jan 24;121(4):707-15.
  • Bolcome RE, Chan J.Constitutive MEK1 Activation Rescues Anthrax Lethal Toxin Induced Vascular Effects In Vivo.Infect Immun. 2010 Sep 20.
  • Vasil ML, Stonehouse MJ, Vasil AI, Wadsworth SJ, Goldfine H, Bolcome RE, Chan J.A complex extracellular sphingomyelinase of Pseudomonas aeruginosa inhibits angiogenesis by selective cytotoxicity to endothelial cells.PLoS Pathog. 2009 May;5(5):e1000420.
  • Bolcome RE 3rd, Sullivan SE, Zeller R, Barker AP, Collier RJ, Chan J.Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature.Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2439-44.
  • Juris SJ, Melnyk RA, Bolcome RE 3rd, Chan J, Collier RJ.Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin.Infect Immun. 2007 Oct;75(10):5052-8.
  • Shu X, Chan J, Ryan RO, Forte TM.Apolipoprotein A-V association with intracellular lipid droplets.J Lipid Res. 2007 Jul;48(7):1445-50.
  • Ho DM, Chan J, Bayliss P, Whitman M.Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.Dev Biol. 2006 Jul 15;295(2):730-42.
  • Bayliss PE, Bellavance KL, Whitehead GG, Abrams JM, Aegerter S, Robbins HS, Cowan DB, Keating MT, O'Reilly T, Wood JM, Roberts TM, Chan J.Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish.Nat Chem Biol. 2006 May;2(5):265-73.
  • Wagle M, Grunewald B, Subburaju S, Barzaghi C, Le Guyader S, Chan J, Jesuthasan S.EphrinB2a in the zebrafish retinotectal system.J. Neurobiol. 2004 Apr;59(1):57-65.
  • Montero JA, Kilian B, Chan J, Bayliss PE, Heisenberg CP.Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells.Curr Biol. 2003 Aug 5;13(15):1279-89.
  • Chan J, Bayliss PE, Wood JM, Roberts TM.Dissection of angiogenic signaling in zebrafish using a chemical genetic approach.Cancer Cell. 2002 Apr;1(3):257-67.
  • Chan J, Mably JD, Serluca FC, Chen JN, Goldstein NB, Thomas MC, Cleary JA, Brennan C, Fishman MC, Roberts TM.Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling.Dev Biol. 2001 Jun 15;234(2):470-82.
  • Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH.Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.Neuron. 2000 Feb;25(2):317-29.